Exoribonuclease 1 Proteins (ERI1)

RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Additionally we are shipping ERI1 Antibodies (71) and ERI1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ERI1 90459 Q8IV48
ERI1 67276 Q7TMF2
ERI1 361159 Q5FVR4
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Top ERI1 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human ERI1 Protein. 100 μg 11 to 18 Days
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse ERI1 Protein. 100 μg 11 to 18 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Yeast Schizosaccharomyces pombe His tag   1 mg 60 to 71 Days
Yeast Rat His tag   1 mg 60 to 71 Days

ERI1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
Rat (Rattus)

More Proteins for Exoribonuclease 1 (ERI1) Interaction Partners

Human Exoribonuclease 1 (ERI1) interaction partners

  1. the crystal structure of a ternary complex of human SLBP RNA binding domain, human 3'hExo, and a 26-nucleotide stem-loop RNA is reported.

  2. 3'hExo is a primary candidate for the exonuclease that initiates rapid decay of histone mRNA upon completion and/or inhibition of DNA replication

  3. molecular cloning; degrades siRNAs in vitro[ERI-1]

  4. Data describe the structure of the nuclease domain of 3'-5'-exoribonuclease (3'hExo) complexed with rAMP in the presence of magnesium at 1.6 A resolution.

  5. 3'hExo is a 3' exonuclease specifically interacting with the 3' end of histone mRNA

Mouse (Murine) Exoribonuclease 1 (ERI1) interaction partners

  1. data demonstrate how degradation of histone mRNAs is initiated when 3' oligouridylation creates a cis element that enables Eri1 to process the double-stranded stem-loop structure

  2. Mouse Eri1 regulates miRNA homeostasis in lymphocytes and is required for normal NK-cell development and antiviral immunity.

  3. The roles of meri-1 (mouse enhanced RNAi) and adar1 in the regulation of RNA interference are reported.

  4. Findings indicate that Eri1 catalyzes the final trimming step in 5.8S rRNA processing, functionally and spatially connecting this regulator of RNAi with the basal translation machinery.

Caenorhabditis elegans (C. elegans) Exoribonuclease 1 (ERI1) interaction partners

  1. In the absence of eri-1, reserpine mediated lifespan extension (RMLE) is shortened. In the dop-3 loss-of-function background, lack of eri-1 completely abolishes RMLE. This suggests that dop-3 and eri-1 act in independent parallel pathways for RMLE and these two pathways are essential and sufficient for the longevity enhancement by reserpine in C. elegans.

  2. results identify novel components of the endo RNAi machinery, demonstrate differential requirements for the Eri factors in the sperm-producing germline, and begin to delineate the functional requirement for the ERI/DICER complex in sperm development

  3. After exposure to dsRNA or siRNAs, animals with eri-1 mutations accumulate more siRNAs than wild-type animals; a negative regulator that may normally function to limit the duration, cell-type specificity or endogenous functions of RNA interference

  4. Feeding unc-13 & eri-1 strains dsRNA corresponding to a neuronally expressed GFP reporter resulted in reduction of GFP in double mutants compared to GFP expression in eri-1 mutants, indicating that UNC-13 functions in conjunction with ERI-1 in RNAi.

  5. These results provide additional support for the hypothesis that RRF-3 and ERI-1 act together in the endo-siRNA pathway, and furthermore suggests their involvement in additional biological processes.

  6. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference.

ERI1 Protein Profile

Protein Summary

RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi.

Gene names and symbols associated with Exoribonuclease 1 Proteins (ERI1)

  • exoribonuclease 1 (ERI1)
  • three prime repair exonuclease 1 (CpipJ_CPIJ003945)
  • exoribonuclease 1 (eri1)
  • exoribonuclease 1 L homeolog (eri1.L)
  • exoribonuclease 1 (Eri1)
  • 3'-5' exonuclease eri-1 (eri-1)
  • 3'hexo protein
  • 3110010F15Rik protein
  • eri-1 protein
  • HEXO protein
  • RGD1308378 protein
  • Thex1 protein
  • zgc:110635 protein

Protein level used designations for Exoribonuclease 1 Proteins (ERI1)

three prime histone mRNA exonuclease 1 , three prime repair exonuclease 1 , 3'-5' exoribonuclease 1 , 3' exoribonuclease , histone mRNA 3' end-specific exonuclease , 3'-5' exonuclease ERI1 , Eri-1 homolog , enhanced RNAi three prime mRNA exonuclease homolog 1 , histone mRNA 3'-end-specific exoribonuclease , histone mRNA 3'-exonuclease 1 , protein 3'hExo , three prime mRNA exonuclease 1 , enhanced RNAi protein 1 , eri-1 homolog , 3 ' exoribonuclease

463978 Pan troglodytes
6035619 Culex quinquefasciatus
100230265 Taeniopygia guttata
553641 Danio rerio
734610 Xenopus laevis
422629 Gallus gallus
90459 Homo sapiens
540728 Bos taurus
67276 Mus musculus
361159 Rattus norvegicus
176868 Caenorhabditis elegans
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