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RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Additionally we are shipping ERI1 Antibodies (73) and ERI1 Kits (6) and many more products for this protein.
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the crystal structure of a ternary complex of human SLBP RNA binding domain, human 3'hExo, and a 26-nucleotide stem-loop RNA is reported.
3'hExo is a primary candidate for the exonuclease that initiates rapid decay of histone mRNA upon completion and/or inhibition of DNA replication
molecular cloning; degrades siRNAs in vitro[ERI-1]
Data describe the structure of the nuclease domain of 3'-5'-exoribonuclease (3'hExo) complexed with rAMP in the presence of magnesium at 1.6 A resolution.
3'hExo is a 3' exonuclease specifically interacting with the 3' end of histone mRNA
data demonstrate how degradation of histone mRNAs is initiated when 3' oligouridylation creates a cis element that enables Eri1 to process the double-stranded stem-loop structure
Mouse Eri1 regulates miRNA homeostasis in lymphocytes and is required for normal NK-cell development and antiviral immunity.
The roles of meri-1 (mouse enhanced RNAi) and adar1 in the regulation of RNA interference are reported.
Findings indicate that Eri1 catalyzes the final trimming step in 5.8S rRNA processing, functionally and spatially connecting this regulator of RNAi with the basal translation machinery.
In the absence of eri-1, reserpine mediated lifespan extension (RMLE) is shortened. In the dop-3 loss-of-function background, lack of eri-1 completely abolishes RMLE. This suggests that dop-3 and eri-1 act in independent parallel pathways for RMLE and these two pathways are essential and sufficient for the longevity enhancement by reserpine in C. elegans.
results identify novel components of the endo RNAi machinery, demonstrate differential requirements for the Eri factors in the sperm-producing germline, and begin to delineate the functional requirement for the ERI/DICER complex in sperm development
After exposure to dsRNA or siRNAs, animals with eri-1 mutations accumulate more siRNAs than wild-type animals; a negative regulator that may normally function to limit the duration, cell-type specificity or endogenous functions of RNA interference
Feeding unc-13 & eri-1 strains dsRNA corresponding to a neuronally expressed GFP reporter resulted in reduction of GFP in double mutants compared to GFP expression in eri-1 mutants, indicating that UNC-13 functions in conjunction with ERI-1 in RNAi.
These results provide additional support for the hypothesis that RRF-3 and ERI-1 act together in the endo-siRNA pathway, and furthermore suggests their involvement in additional biological processes.
In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference.
RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi.
three prime histone mRNA exonuclease 1
, three prime repair exonuclease 1
, 3'-5' exoribonuclease 1
, 3' exoribonuclease
, histone mRNA 3' end-specific exonuclease
, 3'-5' exonuclease ERI1
, Eri-1 homolog
, enhanced RNAi three prime mRNA exonuclease homolog 1
, histone mRNA 3'-end-specific exoribonuclease
, histone mRNA 3'-exonuclease 1
, protein 3'hExo
, three prime mRNA exonuclease 1
, enhanced RNAi protein 1
, eri-1 homolog
, 3 ' exoribonuclease