anti-FIP1 Like 1 (S. Cerevisiae) (FIP1L1) Antibodies

FIP1L1 encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. Additionally we are shipping FIP1 Like 1 (S. Cerevisiae) Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FIP1L1 81608 Q6UN15
FIP1L1 289582 Q5U317
FIP1L1 66899 Q9D824
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Top anti-FIP1 Like 1 (S. Cerevisiae) Antibodies at antibodies-online.com

Showing 10 out of 41 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-FIP1L1 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Jurkat cell lysate FIP1L1 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit Anti-FIP1L1 antibody        Paraffin Embedded Tissue:  Human Brain cell   Cellular Data:  Epithelial cells of renal tubule  Antibody Concentration:   4.0-8.0 ug/ml  Magnification:   400X 100 μL 2 to 3 Days
$289.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Dog Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated IF/ICC, IHC, WB Western blot analysis of extracts of various cell lines, using FIP1L1 antibody (ABIN5974293) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded mouse liver using FIP1L1 antibody (ABIN5974293) at dilution of 1/100 (40x lens). 100 μL 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using FIP1L1 antibody. Immunohistochemistry of paraffin-embedded mouse liver using FIP1L1 antibody. 200 μL 12 to 14 Days
$438.90
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Human Rabbit Un-conjugated WB   100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF/ICC, IHC, WB 100 μL 11 to 18 Days
$383.76
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged FIP1L1 is 0.1 ng/ml as a capture antibody. Western Blot detection against Immunogen (67.32 KDa) . 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB FIP1L1 antibody used at 0.5 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of FIP1L1 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Immunohistochemical analysis of FIP1L1 staining in mouse liver formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the 200 μL 13 to 14 Days
$487.50
Details

Top referenced anti-FIP1 Like 1 (S. Cerevisiae) Antibodies

  1. Human Polyclonal FIP1L1 Primary Antibody for ICC, IF - ABIN4311958 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

More Antibodies against FIP1 Like 1 (S. Cerevisiae) Interaction Partners

Human FIP1 Like 1 (S. Cerevisiae) (FIP1L1) interaction partners

  1. Two identified variants revealed novel candidate genes for hip and knee osteoarthritis. OLIG3 and FIP1L1 have specific roles in transcription and may effect expression of other genes. Identified variants in these genes may thus have a role in the regulatory events leading to osteoarthritis.

  2. Herein, we report a case of a 53-year-old man with eosinophilia and a well-differentiated extramedullary myeloid tumor with evidence of FIP1L1/PDGFRA rearrangement by fluorescent in situ hybridization in the extramedullary tissue.

  3. The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation.

  4. Case Report: concurrent development of myeloproliferative hypereosinophilic syndrome and lymphomatoid papulosis associated with FIP1L1-PDGFRA gene fusion.

  5. FIP1L1/ PDGFRA associated chronic eosinophilic leukemia has an excellent long-term prognosis following imatinib therapy.

  6. F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC and is associated with kinase inhibitor resistance in hypereosinophilic syndrome and chronic eosinophilic leukemia.

  7. FIP1L1 differentially contributes to the pathogenesis of distinct types of leukemia.

  8. FP fusion gene favors secondary KIT mutations in MCs via growth and proliferation signals or that a yet unknown mechanism causes genomic instability with independent evolution of FP and KIT D816V

  9. Oncostatin M is a FIP1L1/PDGFRA-dependent mediator of cytokine production in chronic eosinophilic leukemia.

  10. description of polycythemia vera concurrent with FIP1L1-PDGFRA-positive myeloproliferative neoplasm with eosinophilia [case report]

  11. Data show that the cyclin-dependent kinase 7/9 inhibitor (CDK7/9 inhibitor) potently inhibits FIP1L1-PDGFRalpha-positive Bcr-Abl-positive chronic myeloid leukemia (CML) cells.

  12. results strongly suggest that JAK2 is activated by Fip1-like1 (FIP1L1)-platelet-derived growth factor receptor alpha (F/P) and is required for F/P stimulation of cellular proliferation and infiltration in chronic eosinophilic leukemia

  13. Treatment with imatinib is associated with an excellent prognosis in FIP1L1-PDGFRA-positive chronic eosinophilic leukemia in first chronic phase

  14. FIP1L1/PDGFRA fusion gene-positive myeloproliferative disorders with eosinophilia are discussed.

  15. The hypereosinophilic syndrome may result from a novel fusion tyrosine kinase - FIP1L1-PDGFRalpha - that is a consequence of an interstitial chromosomal deletion.

  16. observations suggest that the FIP1L1-PDGFRA rearrangement occurs in an early hematopoietic progenitor and suggests that the molecular pathogenesis for a subset of SMCD patients is similar to that of HES

  17. results indicate that the fusion of FIP1L1 to PDGFRA occurs rarely in leukemia cell lines

  18. FIP1L1-PDGFRA is a relatively infrequent but treatment-relevant mutation in primary eosinophilia that is indicative of an underlying systemic mastocytosis.

  19. the newly identified hFip1 protein, which has been shown to enhance polyadenylation through U-rich upstream elements, interacted specifically with the HPV-16 upstream element.

  20. Fusion protein is detected in hypereosinophilic syndrome and chronic eosinophilic leukemia.

Mouse (Murine) FIP1 Like 1 (S. Cerevisiae) (FIP1L1) interaction partners

  1. FIP1L1-PDGFRalpha activation requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent

FIP1 Like 1 (S. Cerevisiae) (FIP1L1) Antigen Profile

Protein Summary

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with FIP1L1

  • factor interacting with PAPOLA and CPSF1 (fip1l1) antibody
  • factor interacting with PAPOLA and CPSF1 (FIP1L1) antibody
  • factor interacting with PAPOLA and CPSF1 S homeolog (fip1l1.S) antibody
  • factor interacting with PAPOLA and CPSF1 (Fip1l1) antibody
  • FIP1 like 1 (S. cerevisiae) (Fip1l1) antibody
  • FIP1 like 1b (S. cerevisiae) (fip1l1b) antibody
  • 1300019H17Rik antibody
  • FIP1 antibody
  • fip1l1 antibody
  • hFip1 antibody
  • Rhe antibody
  • Rje antibody
  • wu:fd36f11 antibody
  • zgc:103421 antibody

Protein level used designations for FIP1L1

FIP1 like 1 , FIP1-like 1 protein , pre-mRNA 3'-end-processing factor FIP1 , FIP1L1 cleavage and polyadenylation specific factor subunit , factor interacting with PAP , rearranged in hypereosinophilia

GENE ID SPECIES
733481 Xenopus (Silurana) tropicalis
100172699 Pongo abelii
81608 Homo sapiens
494780 Xenopus laevis
289582 Rattus norvegicus
422754 Gallus gallus
612980 Canis lupus familiaris
100138550 Bos taurus
66899 Mus musculus
450021 Danio rerio
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