anti-FK506 Binding Protein 5 (FKBP5) Antibodies

The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FKBP5 Kits (16) and FKBP5 Proteins (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FKBP5 2289 Q13451
FKBP5 14229 Q64378
FKBP5 361810  
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Top anti-FKBP5 Antibodies at antibodies-online.com

Showing 10 out of 152 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Mouse Un-conjugated ICC, IF, WB FKBP51 HS Hela 10ug 1 in 1000 Western Blotting copy. 100 μg Log in to see 2 to 3 Days
$399.30
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: FKBP51/FKBP5 Antibody [NBP1-84676] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) Immunohistochemistry-Paraffin: FKBP51/FKBP5 Antibody [NBP1-84676] - Staining of human kidney shows strong cytoplasmic and nuclear positivity in cells in tubules and strong nuclear staining in cells in glomeruli. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: FKBP5/FKBP51 Antibody [ABIN2611550] - Human prostate carcinoma. Antibody used at a dilution of 1:1,000. 0.1 mL Log in to see 7 to 9 Days
$556.31
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-FKBP5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. This image was taken for the unconjugated form of this product. ... 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Mouse Un-conjugated IF, IHC (p), WB FKBP5 MaxPab polyclonal antibody. Western Blot analysis of FKBP5 expression in human placenta. Western Blot analysis of FKBP5 expression in transfected 293T cell line by FKBP5 MaxPab polyclonal antibody.<br><br>Lane 1: FKBP5 transfected lysate(50.27 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, IF, WB Detection limit for recombinant GST tagged FKBP5 is approximately 0.03 ng/mL as a capture antibody. Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (76.01 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$522.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: FKBP5/FKBP51 Antibody [NBP1-84677] - Staining of human stomach shows strong nuclear positivity in glandular cells. Immunocytochemistry/Immunofluorescence: FKBP5/FKBP51 Antibody [NBP1-84677] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details

FKBP5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FKBP5 Antibodies

  1. Human Polyclonal FKBP5 Primary Antibody for IF, IHC (p) - ABIN515669 : Romano, Staibano, Greco, Brunetti, Nappo, Ilardi, Martinelli, Sorrentino, Di Pace, Mascolo, Bisogni, Scalvenzi, Alfano, Romano: FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. in Cell death & disease 2013 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal FKBP5 Primary Antibody for ICC, IF - ABIN261155 : Romano, DAngelillo, Staibano, Simeone, DArrigo, Ascierto, Scalvenzi, Mascolo, Ilardi, Merolla, Jovarauskaite, Romano: Immunomodulatory pathways regulate expression of a spliced FKBP51 isoform in lymphocytes of melanoma patients. in Pigment cell & melanoma research 2015 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal FKBP5 Primary Antibody for ELISA, WB - ABIN560908 : van Lierop, Alkema, Laskewitz, Dijkema, van der Maaden, Smit, Plate, Conti, Jans, Timmers, van Boeckel, Lusher, McGuire, van Schaik, de Vlieg, Smeets, Hofstra, Boots, van Duin, Ingelse, Schoonen et al.: Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index. ... in PLoS ONE 2012 (PubMed)

  4. Dog (Canine) Monoclonal FKBP5 Primary Antibody for ICC, IF - ABIN361795 : Cheung-Flynn, Roberts, Riggs, Smith: C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90. in The Journal of biological chemistry 2003 (PubMed)
    Show all 6 Pubmed References

More Antibodies against FKBP5 Interaction Partners

Human FK506 Binding Protein 5 (FKBP5) interaction partners

  1. The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking.

  2. Study found that DNA methylation (show HELLS Antibodies) levels in multiple genomic regions of FKBP5, a regulator of glucocorticoid response sensitivity, does not mediate the relationship between childhood maltreatment (CM) and depression symptom severity; also a significant increase in FKBP5 gene expression (GE) levels associated with lifetime major depressive disorder, but found no significant difference in GE levels related to exposure to CM.

  3. study thus provides support for an association between specific FKBP5 genetic variants and MDD risk

  4. Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes.

  5. The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of mediators of an internalizing pathway to problem drinking.

  6. FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity.

  7. Exposure to childhood physical abuse may increase the risk for sub-clinical depressive and anxiety symptoms depending on FKBP5 genetic variability.

  8. SNPs moderate the association of positive and negative recent life events (LEs (show FUT3 Antibodies)) with depressive symptoms, state-anxiety, neuroticism, and social anxiety traits

  9. In humans, abnormal fear extinction was associated with the TT homozygous genotype of FKBP5 SNPs RS9470080 and RS1360780, and hyperarousal symptoms. Results indicate that FKBP5 confers risk for abnormal fear extinction learning in humans, which may drive the development of arousal symptomatology and ultimately the development of posttraumatic stress disorder.

  10. These results provide strong evidence of interactions between FKBP5 genotypes and early-life stress, which could pose a significant risk factor for stress-associated disorders such as major depression and post-traumatic stress disorder (PTSD).

Mouse (Murine) FK506 Binding Protein 5 (FKBP5) interaction partners

  1. High FKBP5 expression is associated with anxiety/depression.

  2. In mice, dexamethasone 300 mug/kg was associated with increased amygdala Fkbp5 mRNA following fear extinction and robust extinction learning while lower doses were not associated with amygdala Fkbp5 mRNA or differences in extinction learning. Further, mice that extinguished on dexamethasone 300 mug/kg maintained low levels of freezing behavior during recall training while mRNA levels were no longer elevated.

  3. These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (show HSP90 Antibodies) cochaperone activity of FKBP51 with a functional impact on GR signaling in a neuronal context.

  4. Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.

  5. important regulator of PPARgamma (show PPARG Antibodies) in white adipose tissue

  6. FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice

  7. findings show that miR (show MLXIP Antibodies)-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.

  8. These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.

  9. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3beta at serine 9 (pGSK3beta(S9)).

  10. Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation (show HELLS Antibodies), and its subsequent regulation of glucocorticoid receptor (show NR3C1 Antibodies) sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton

FKBP5 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FKBP5

  • FK506 binding protein 5 (FKBP5) antibody
  • FK506 binding protein 5 (fkbp5) antibody
  • FK506 binding protein 5 (Fkbp5) antibody
  • AIG6 antibody
  • D17Ertd592e antibody
  • Dit1 antibody
  • FKBP-5 antibody
  • FKBP5 antibody
  • FKBP51 antibody
  • FKBP54 antibody
  • P54 antibody
  • PPIase antibody
  • Ptg-10 antibody
  • si:zc263a23.8 antibody
  • wu:fc31g11 antibody
  • wu:fl87b03 antibody
  • zgc:64082 antibody

Protein level used designations for FKBP5

FK506 binding protein 5 , FK506-binding protein 5 , PPIase FKBP5 , peptidyl-prolyl cis-trans isomerase FKBP5 , rotamase , 51 kDa FK506-binding protein 5 , 51 kDa FKBP , 54 kDa progesterone receptor-associated immunophilin , FF1 antigen , FKBP-5 , FKBP-51 , HSP90-binding immunophilin , T-cell FK506-binding protein , androgen-regulated protein 6 , peptidylprolyl cis-trans isomerase , 51 kDa FK506-binding protein

GENE ID SPECIES
462639 Pan troglodytes
100171536 Pongo abelii
100544523 Meleagris gallopavo
100551895 Anolis carolinensis
100591277 Nomascus leucogenys
2289 Homo sapiens
14229 Mus musculus
361810 Rattus norvegicus
368924 Danio rerio
421186 Gallus gallus
481759 Canis lupus familiaris
100155423 Sus scrofa
535704 Bos taurus
100339155 Oryctolagus cuniculus
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