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The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FKBP5 Kits (16) and FKBP5 Proteins (13) and many more products for this protein.
Showing 10 out of 152 products:
Human Polyclonal FKBP5 Primary Antibody for IF, IHC (p) - ABIN515669
Romano, Staibano, Greco, Brunetti, Nappo, Ilardi, Martinelli, Sorrentino, Di Pace, Mascolo, Bisogni, Scalvenzi, Alfano, Romano: FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. in Cell death & disease 2013
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Human Polyclonal FKBP5 Primary Antibody for ICC, IF - ABIN261155
Romano, DAngelillo, Staibano, Simeone, DArrigo, Ascierto, Scalvenzi, Mascolo, Ilardi, Merolla, Jovarauskaite, Romano: Immunomodulatory pathways regulate expression of a spliced FKBP51 isoform in lymphocytes of melanoma patients. in Pigment cell & melanoma research 2015
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Human Monoclonal FKBP5 Primary Antibody for ELISA, WB - ABIN560908
van Lierop, Alkema, Laskewitz, Dijkema, van der Maaden, Smit, Plate, Conti, Jans, Timmers, van Boeckel, Lusher, McGuire, van Schaik, de Vlieg, Smeets, Hofstra, Boots, van Duin, Ingelse, Schoonen et al.: Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index. ... in PLoS ONE 2012
Dog (Canine) Monoclonal FKBP5 Primary Antibody for ICC, IF - ABIN361795
Cheung-Flynn, Roberts, Riggs, Smith: C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90. in The Journal of biological chemistry 2003
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The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking.
Study found that DNA methylation (show HELLS Antibodies) levels in multiple genomic regions of FKBP5, a regulator of glucocorticoid response sensitivity, does not mediate the relationship between childhood maltreatment (CM) and depression symptom severity; also a significant increase in FKBP5 gene expression (GE) levels associated with lifetime major depressive disorder, but found no significant difference in GE levels related to exposure to CM.
study thus provides support for an association between specific FKBP5 genetic variants and MDD risk
Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes.
The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of mediators of an internalizing pathway to problem drinking.
FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity.
Exposure to childhood physical abuse may increase the risk for sub-clinical depressive and anxiety symptoms depending on FKBP5 genetic variability.
SNPs moderate the association of positive and negative recent life events (LEs (show FUT3 Antibodies)) with depressive symptoms, state-anxiety, neuroticism, and social anxiety traits
In humans, abnormal fear extinction was associated with the TT homozygous genotype of FKBP5 SNPs RS9470080 and RS1360780, and hyperarousal symptoms. Results indicate that FKBP5 confers risk for abnormal fear extinction learning in humans, which may drive the development of arousal symptomatology and ultimately the development of posttraumatic stress disorder.
These results provide strong evidence of interactions between FKBP5 genotypes and early-life stress, which could pose a significant risk factor for stress-associated disorders such as major depression and post-traumatic stress disorder (PTSD).
High FKBP5 expression is associated with anxiety/depression.
In mice, dexamethasone 300 mug/kg was associated with increased amygdala Fkbp5 mRNA following fear extinction and robust extinction learning while lower doses were not associated with amygdala Fkbp5 mRNA or differences in extinction learning. Further, mice that extinguished on dexamethasone 300 mug/kg maintained low levels of freezing behavior during recall training while mRNA levels were no longer elevated.
These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (show HSP90 Antibodies) cochaperone activity of FKBP51 with a functional impact on GR signaling in a neuronal context.
Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.
important regulator of PPARgamma (show PPARG Antibodies) in white adipose tissue
FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice
findings show that miR (show MLXIP Antibodies)-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.
These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.
We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3beta at serine 9 (pGSK3beta(S9)).
Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation (show HELLS Antibodies), and its subsequent regulation of glucocorticoid receptor (show NR3C1 Antibodies) sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
FK506 binding protein 5
, FK506-binding protein 5
, PPIase FKBP5
, peptidyl-prolyl cis-trans isomerase FKBP5
, 51 kDa FK506-binding protein 5
, 51 kDa FKBP
, 54 kDa progesterone receptor-associated immunophilin
, FF1 antigen
, HSP90-binding immunophilin
, T-cell FK506-binding protein
, androgen-regulated protein 6
, peptidylprolyl cis-trans isomerase
, 51 kDa FK506-binding protein