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The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FKBP5 Proteins (13) and FKBP5 Kits (12) and many more products for this protein.
Showing 10 out of 128 products:
Human Polyclonal FKBP5 Primary Antibody for IF, IHC (p) - ABIN515669
Romano, Staibano, Greco, Brunetti, Nappo, Ilardi, Martinelli, Sorrentino, Di Pace, Mascolo, Bisogni, Scalvenzi, Alfano, Romano: FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. in Cell death & disease 2013
Show all 3 Pubmed References
Human Polyclonal FKBP5 Primary Antibody for ICC, IF - ABIN261155
Romano, DAngelillo, Staibano, Simeone, DArrigo, Ascierto, Scalvenzi, Mascolo, Ilardi, Merolla, Jovarauskaite, Romano: Immunomodulatory pathways regulate expression of a spliced FKBP51 isoform in lymphocytes of melanoma patients. in Pigment cell & melanoma research 2015
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Human Monoclonal FKBP5 Primary Antibody for ELISA, WB - ABIN560908
van Lierop, Alkema, Laskewitz, Dijkema, van der Maaden, Smit, Plate, Conti, Jans, Timmers, van Boeckel, Lusher, McGuire, van Schaik, de Vlieg, Smeets, Hofstra, Boots, van Duin, Ingelse, Schoonen et al.: Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index. ... in PLoS ONE 2012
Dog (Canine) Monoclonal FKBP5 Primary Antibody for ICC, IF - ABIN361795
Cheung-Flynn, Roberts, Riggs, Smith: C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90. in The Journal of biological chemistry 2003
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These results provide strong evidence of interactions between FKBP5 genotypes and early-life stress, which could pose a significant risk factor for stress-associated disorders such as major depression and post-traumatic stress disorder (PTSD).
FKBP5 polymorphisms in combination with early life stress exposure predict higher insulin (show INS Antibodies) and glucose values in midlife.
GxE interaction between child maltreatment and FKBP5 on dissociative symptoms in adolescence.
Children with high attachment insecurity and homozygous FKBP5 minor alleles manifest maladaptive emotion regulation and depressive symptoms.
This study demonstrated that FKBP5 Messenger RNA Increases After Adolescence in Human Dorsolateral Prefrontal Cortex.
A novel FKBP5 1V55L mutation is associated with Paget's disease in a Chinese family. Mutant FKBP51V55L promotes osteoclastogenesis.
A negative correlation between basal levels of FKBP5 methylation and serum cortisol was observed.
Study found an additive interaction effect between FKBP5's rs1360780 variant and the graph-theoretical metrics of hippocampal connectivity to influence depression risk. Data reveals alterations of the communication patterns between the hippocampus and the rest of the brain in depression, effects potentially driven by overall familial factors (genes plus shared twin environment) and modified by the FKBP5 gene.
This study demonstrated suggest that FKBP5 in the GR pathway may be a point of vulnerability to early-life adversity, as seen in this group of non-traumatized young adults.
Association of FKBP5 haplotype with risk of suicide attempt.
These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (show HSP90 Antibodies) cochaperone activity of FKBP51 with a functional impact on GR signaling in a neuronal context.
Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.
important regulator of PPARgamma (show PPARG Antibodies) in white adipose tissue
FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice
findings show that miR (show MLXIP Antibodies)-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.
These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.
We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3beta at serine 9 (pGSK3beta(S9)).
Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation (show HELLS Antibodies), and its subsequent regulation of glucocorticoid receptor (show NR3C1 Antibodies) sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton
the abundance of BDNF (show BDNF Antibodies) positively correlated and phosphorylated DNMT1 (show DNMT1 Antibodies) inversely correlated with that of FKBP51 in cells
FKBP5 associates with BECN1 (show BECN1 Antibodies), changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
FK506 binding protein 5
, FK506-binding protein 5
, PPIase FKBP5
, peptidyl-prolyl cis-trans isomerase FKBP5
, 51 kDa FK506-binding protein 5
, 51 kDa FKBP
, 54 kDa progesterone receptor-associated immunophilin
, FF1 antigen
, HSP90-binding immunophilin
, T-cell FK506-binding protein
, androgen-regulated protein 6
, peptidylprolyl cis-trans isomerase
, 51 kDa FK506-binding protein