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FKBP5 antibody (Biotin)

FKBP5 Reactivity: Human WB, IF, ICC Host: Mouse Monoclonal Hi51B Biotin
Catalog No. ABIN2486512
  • Target See all FKBP5 Antibodies
    FKBP5 (FK506 Binding Protein 5 (FKBP5))
    Reactivity
    • 57
    • 20
    • 17
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 46
    • 17
    • 1
    Mouse
    Clonality
    • 40
    • 24
    Monoclonal
    Conjugate
    • 32
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FKBP5 antibody is conjugated to Biotin
    Application
    • 43
    • 18
    • 17
    • 14
    • 12
    • 8
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    Detects ~51 kDa.
    Cross-Reactivity
    Dog, Hamster, Human, Mouse, Rabbit, Rat
    Purification
    Protein G Purified
    Immunogen
    Synthetic peptide corresponding to the residues of human FKBP51
    Clone
    Hi51B
    Isotype
    IgG1
    Top Product
    Discover our top product FKBP5 Primary Antibody
  • Application Notes
    • WB (1:2000)
    • ICC/IF (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Comment

    A 1:2000 dilution was sufficient for detection of FKBP51 in ~50 μg total protein using WB analysis.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    FKBP5 (FK506 Binding Protein 5 (FKBP5))
    Alternative Name
    FKBP51 (FKBP5 Products)
    Synonyms
    FKBP5 antibody, FKBP-5 antibody, AIG6 antibody, FKBP51 antibody, FKBP54 antibody, P54 antibody, PPIase antibody, Ptg-10 antibody, D17Ertd592e antibody, Dit1 antibody, si:zc263a23.8 antibody, wu:fc31g11 antibody, wu:fl87b03 antibody, zgc:64082 antibody, FK506 binding protein 5 antibody, FKBP5 antibody, fkbp5 antibody, Fkbp5 antibody
    Background
    HSP90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of HSP90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an HSP90 binding site. Among the TPR cochaperones of HSP90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the HSP90 (4). Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different HSP90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).
    Gene ID
    2289
    NCBI Accession
    NP_001139247
    UniProt
    Q13451
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