anti-Family with Sequence Similarity 38, Member B (FAM38B) Antibodies

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains.

list all antibodies Gene Name GeneID UniProt
FAM38B 63895 Q9H5I5
FAM38B 667742 Q8CD54
FAM38B 307380  
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Top anti-Family with Sequence Similarity 38, Member B Antibodies at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-FAM38B Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  721_B cell lysate PIEZO2 is supported by BioGPS gene expression data to be expressed in 721_B 100 μL 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  PIEZO2  Sample Type:  293T Whole Cell lysates  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of FAM38B Antibody (C-term) in CEM cell line lysates (35ug/lane). This demonstrates the FAM38B antibody detected the FAM38B protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated WB FAM38B antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Details
Human Rabbit Un-conjugated ELISA, WB   0.1 mg 2 to 3 Days
$360.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with PIEZO2 polyclonal antibody . Immunohistochemical staining of human colon with PIEZO2 polyclonal antibody  shows moderate cytoplasmic positivity in glandular cells. 100 μL 11 to 12 Days
$577.33
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL 11 to 16 Days
$658.43
Details

Top referenced anti-Family with Sequence Similarity 38, Member B Antibodies

  1. Human Polyclonal FAM38B Primary Antibody for ICC, IF - ABIN4345486 : Florez-Paz, Bali, Kuner, Gomis: A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons. in Scientific reports 2016 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal FAM38B Primary Antibody for ICC, IF - ABIN4345484 : Lee, Leddy, Chen, Lee, Zelenski, McNulty, Wu, Beicker, Coles, Zauscher, Grandl, Sachs, Guilak, Liedtke: Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. in Proceedings of the National Academy of Sciences of the United States of America 2014 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal FAM38B Primary Antibody for ICC, IF - ABIN4345487 : Poole, Herget, Lapatsina, Ngo, Lewin: Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch. in Nature communications 2014 (PubMed)

More Antibodies against Family with Sequence Similarity 38, Member B Interaction Partners

Human Family with Sequence Similarity 38, Member B (FAM38B) interaction partners

  1. individuals with loss-of-function mutations in PIEZO2 completely failed to develop sensitization and painful reactions to touch after skin inflammation.

  2. the presence of both Piezo1 and 2 in enteric neurons throughout the gastrointestinal tract from guinea pigs, mice and humans, were studied.

  3. Novel mutations in TPM2 and PIEZO2 are responsible for distal arthrogryposis (DA) 2B and mild DA in two Chinese families.

  4. The molecular defects identified through clinical exome sequencing in this study expands the phenotypic spectra of CHD7-associated disorders and implicate PIEZO2 as a candidate gene for major eye developmental defects.

  5. This study identified Piezo2 mechanosensitive cationic channel as a transducer of environmental physical cues into mechanobiological responses.

  6. The present results demonstrate the occurrence of Piezo2 in cutaneous sensory nerve formations that functionally work as slowly adapting (Merkel cells) and rapidly adapting (Meissner's corpuscles) low-threshold mechanoreceptors and are related to fine and discriminative touch but not to vibration or hard touch

  7. Study demonstrate the splicing of Piezo2 to be cell type specific. Biophysical characterization revealed substantial differences in ion permeability, sensitivity to calcium modulation, and inactivation kinetics among Piezo2 splice variants.

  8. we report the developmental phenotypic spectrum of familial Gordon syndrome in one family due to the previously characterized PIEZO2 mutation c.8057G>A.

  9. Enterochromaffin cells in the human and mouse small bowel GI epithelium selectively express the mechanosensitive ion channel Piezo2, and also that activation of Piezo2 by force leads to inward currents, 5-HT release and an increase in mucosal secretion

  10. The Piezo2 convert a variety of mechanical stimuli into channel activation and subsequent inactivation, and what molecules and mechanisms modulate Piezo function.

  11. we report a consanguineous family with three siblings who showed short stature, scoliosis, gross motor impairment, and a progressive form of contractures involving the distal joints that is distinct from that found in patients with domina Recessive mutations in PIEZO2 thus appear to cause a progressive phenotype that overlaps with, while being mostly distinct from that associated with dominant mutations in the same gene

  12. Sensory ataxia and proprioception defect with dorsal column involvement together with arthrogryposis, myopathy, scoliosis and progressive respiratory failure may represent a distinct clinical phenotype, and indicate recessive mutations in PIEZO2

  13. We identified homozygous loss of function variants in PIEZO2 as the underlying cause for an autosomal-recessive distal muscular atrophy with arthrogryposis, kyphoscoliosis, and neonatal respiratory insufficiency distinct from previously described dominant PIEZO2 diseases.

  14. Our results show that PIEZO2 is a determinant of mechanosensation in humans.

  15. Transgenic mouse lines lacking Piezo2 in proprioceptive neurons showed severely uncoordinated body movements.

  16. Whole-exome sequencing revealed a novel heterozygous mutation c.4456G>C (p.A1486P) of PIEZO2.

  17. family of mechanically activated channels that counts only two members in human, piezo1 and 2, has emerged recently. [review]

  18. we demonstrate that the mechanosensitivity of human embryonic stem cell-derived touch receptors depends on PIEZO2

  19. this study used exome sequencing to discover that mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5.

  20. Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis.

Mouse (Murine) Family with Sequence Similarity 38, Member B (FAM38B) interaction partners

  1. individuals with loss-of-function mutations in PIEZO2 completely failed to develop sensitization and painful reactions to touch after skin inflammation.

  2. Piezo2 mediates inflammation- and nerve injury-induced sensitized mechanical pain.

  3. we identified a PI(3,5)P2 binding region in Piezo2, but not Piezo1, that confers sensitivity to Mtmr2 as indicated by functional analysis of a domain-swapped Piezo2 mutant. Altogether, our results propose local PI(3,5)P2 modulation via Mtmr2 in the vicinity of Piezo2 as a novel mechanism to dynamically control Piezo2-dependent mechanotransduction in peripheral sensory neurons.

  4. the presence of both Piezo1 and 2 in enteric neurons throughout the gastrointestinal tract from guinea pigs, mice and humans, were studied.

  5. These findings suggest that PIEZO1 and PIEZO2 are the long-sought baroreceptor mechanosensors critical for acute blood pressure control.

  6. Study establishes the role of epithelial Piezo2 mechanosensitive ion channels in regulation of intestinal physiology.

  7. Mechanoinsensitive ''silent'' nociceptors are characterized by the expression of the nicotinic acetylcholine receptor subunit alpha-3 (CHRNA3); the mechanically gated ion channel PIEZO2 mediates NGF-induced mechanosensitivity in these neurons.

  8. Targeted genetic deletion of Merkel cells and associated mechanosensitive Piezo2 channels in the skin was sufficient to produce alloknesis.

  9. Study demonstrate the splicing of Piezo2 to be cell type specific. Biophysical characterization revealed substantial differences in ion permeability, sensitivity to calcium modulation, and inactivation kinetics among Piezo2 splice variants.

  10. Data provide evidence that Piezo2 plays a critical role in a defined homogeneous population of proprioceptor neurons that innervate the head muscles, demonstrating that this ion channel is essential for mammalian proprioceptive mechanotransduction.

  11. Piezo ion channels act as frequency filters of both the onset and continuation of repetitive mechanical stimuli.

  12. Data show that Piezo2 knockdown led to decreased glioma angiogenesis and reduced vascular hyperpermeability.

  13. experiments demonstrate a role for Pericentrin in modulating Piezo2 activity and membrane expression in somatosensory neurons

  14. Enterochromaffin cells in the human and mouse small bowel GI epithelium selectively express the mechanosensitive ion channel Piezo2, and also that activation of Piezo2 by force leads to inward currents, 5-HT release and an increase in mucosal secretion

  15. Piezo2 is an airway stretch sensor; Piezo2-mediated mechanotransduction within various airway-innervating sensory neurons is critical for establishing efficient respiration at birth and maintaining normal breathing in adult mice

  16. Astrocytes in optic nerve head express multiple mechanosensitive channels, in particular Piezo1 and 2. The expression of putative mechanosensitive channels in these cells may contribute to their responsiveness to traumatic or glaucomatous injury.

  17. lysine substitution of E2416 alters conductance, ion selectivity and pore block of the channel

  18. mice lacking Piezo2 in both adult sensory neurons and Merkel cells exhibit a profound loss of touch sensation

  19. engineered mice deficient in Piezo2 in the skin, but not in sensory neurons, show that Merkel-cell mechanosensitivity completely depends on Piezo2

  20. data indicate that the Epac1-Piezo2 axis has a role in the development of mechanical allodynia during neuropathic pain

Family with Sequence Similarity 38, Member B (FAM38B) Antigen Profile

Protein Summary

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons (Coste et al., 2010

Gene names and symbols associated with FAM38B

  • piezo type mechanosensitive ion channel component 2 (PIEZO2) antibody
  • piezo-type mechanosensitive ion channel component 2 (Piezo2) antibody
  • 5930434P17 antibody
  • 9030411M15Rik antibody
  • 9430028L06Rik antibody
  • C18orf30 antibody
  • C18orf58 antibody
  • Fam38b antibody
  • Fam38b2 antibody
  • HsT748 antibody
  • HsT771 antibody
  • RGD1306866 antibody

Protein level used designations for FAM38B

family with sequence similarity 38, member B , family with sequence similarity 38, member B2 , protein PIEZO2

GENE ID SPECIES
63895 Homo sapiens
667742 Mus musculus
307380 Rattus norvegicus
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