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The protein encoded by FAF2 is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals.
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Human Polyclonal FAF2 Primary Antibody for WB - ABIN525021
Lee, Zhang, Feramisco, Gong, Ye: Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step. in The Journal of biological chemistry 2008
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Human Polyclonal FAF2 Primary Antibody for ELISA, WB - ABIN249994
Hartman, Liu, Zehmer, Luby-Phelps, Jo, Anderson, DeBose-Boyd: Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets. in The Journal of biological chemistry 2010
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Human Polyclonal FAF2 Primary Antibody for WB - ABIN525022
Beilstein, Bouchoux, Rousset, Demignot: Proteomic analysis of lipid droplets from Caco-2/TC7 enterocytes identifies novel modulators of lipid secretion. in PLoS ONE 2013
UBXD8 is necessary for sterol-stimulated dislocation of ubiquitylated HMGCR (show HMGCR Antibodies) from the endoplasmic reticulum membrane en route to proteasomal degradation, a function dependent on its UBX domain.
that newly synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 (show PEX19 Antibodies) and membrane-integrated PEX3 (show PEX3 Antibodies), proteins hitherto exclusively implicated in peroxisome biogenesis
role of UBXD8 in cellular responses to excess fatty acids
the UAS domain of Ubxd8 mediates it's polymerization upon interaction with long-chain unsaturated fatty acids
UBXD8-mediated recruitment of p97/VCP (show vcp Antibodies) to LDs increases lipid droplet (LD) size by inhibiting the activity of adipose triglyceride lipase (ATGL (show PNPLA2 Antibodies)), the rate-limiting enzyme in triacylglycerol hydrolysis.
Ubx2 and Ubxd8 regulates lipid droplet homeostasis.
These results indicate that ApoB (show APOB Antibodies) after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 (show DERL1 Antibodies) and UBXD8 are engaged in the predislocation and postdislocation steps, respectively.
These results suggest that Ubxd8 acts as a brake that limits triglyceride synthesis, and this brake is released when its structure is altered by exposure to unsaturated fatty acids.
These findings provide evidence for conserved ubiquitination pathways regulating the RasGAP (show RASA1 Antibodies) proteins Ira2 (in yeast) and neurofibromin (show NF1 Antibodies) (in humans).
ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients
The results indicate that although UBXD8 functionality can be largely compensated in the normal setting, it is crucial to sustain VLDL secretion when exposed to a dietary challenge of high fat.
Depletion of UBXD8 in hepatocytes suppresses VLDL secretion, and could lead to periportal steatosis when mice are fed a high-fat diet.
The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.
Fas associated factor family member 2
, UBX domain containing 8
, FAS-associated factor 2-like
, FAS-associated factor 2
, UBX domain protein 3B
, UBX domain-containing protein 3B
, UBX domain-containing protein 8
, expressed in T-cells and eosinophils in atopic dermatitis
, protein expressed in T-cells and eosinophils in atopic dermatitis
, FAS-associated factor 2-A
, UBX domain-containing protein 8-A