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Acts as a regulator of the antiangiogenic activity on endothelial cells. Additionally we are shipping and many more products for this protein.
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Studies have shown that FILIP1L expression is related with inhibition of metastases and chemoresistance of ovarian neoplasm, which is associated with downregulation of EMT (show ITK Antibodies) through beta-catenin (show CTNNB1 Antibodies) degradation. FILIP1L expression correlates with significantly improved overall survival.
these findings suggest that FILIP1L reduces beta-catenin (show CTNNB1 Antibodies) levels, which may lead to the transcriptional downregulation of WNT (show WNT2 Antibodies) target genes such as MMPs, resulting in inhibition of metastasis
down-regulation of FILIP1L associated with DNA methylation (show HELLS Antibodies) is related with the invasive phenotype in various cancers.
In addition, eight genes classified as 'second tier' hits in the original study (PAX7 (show PAX7 Antibodies), THADA, COL8A1 (show COL8A1 Antibodies)/FILIP1L, DCAF4L2, GADD45G (show GADD45G Antibodies), NTN1 (show NTN1 Antibodies), RBFOX3 (show RBFOX3 Antibodies) and FOXE1 (show FOXE1 Antibodies)) showed evidence of linkage and association in this replication sample.
these findings suggest that downregulation of FILIP1L associated with DNA methylation (show HELLS Antibodies) is related with the invasive phenotype in ovarian cancer and that modulation of FILIP1L expression has the potential to be a target for ovarian cancer therapy.
a novel function for FILIP-1L and a pathway for Hsf1 degradation through the ubiquitin-proteasome system.
GPBP (show COL4A3BP Antibodies) directs myofibril formation through interaction with intracellular downstream effector 130-kDa GPBP-interacting protein
DOC1 (show CDK2AP1 Antibodies) might play a role in mediating some of the effects of EMAP-II on endothelial cells
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor- associated vasculature.
130 kDa GPBP-interacting protein
, 90 kDa GPBP-interacting protein
, GPBP-interacting protein 90
, GPBP-interacting protein of 130 kDa
, downregulated in ovarian cancer 1 81 kDa isoform
, filamin A-interacting protein 1-like
, protein down-regulated in ovarian cancer 1
, downregulated in ovarian cancer 1-like
, protein down-regulated in ovarian cancer 1 homolog
, filamin A interacting protein 1-like