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GIMAP4 encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins.
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Human Polyclonal GIMAP4 Primary Antibody for IHC, IHC (p) - ABIN4314120
Lee, Horie, Wallace, Choi, Park, Choi, Song, Kang, Kang, Baek, Kitaichi, Meguro, Mizuki, Namba, Ishida, Kim, Niemczyk, Lee, Song, Ohno, Lee: Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease. in Annals of the rheumatic diseases 2013
GIMAP4 regulates secretion of cytokines in early differentiating human CD4 (show CD4 Antibodies)(+) T helper lymphocytes and in particular the secretion of interferon-gamma (show IFNG Antibodies) also affecting its downstream targets.
GIMAP1 (show GIMAP1 Antibodies) and GIMAP4 genes are up-regulated by IL-12 (show IL12A Antibodies) and other Th1 (show TH1L Antibodies) differentiation-inducing cytokines in cells induced to differentiate toward Th1 (show TH1L Antibodies) lineage and down-regulated by IL-4 (show IL4 Antibodies) in cells induced to Th2.
Gimap4 accelerates the execution of programmed cell death induced by intrinsic stimuli downstream of caspase-3 (show CASP3 Antibodies) activation and phosphatidylserine exposure. Apoptosis directly correlates with the phosphorylation status of Gimap4.
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1.
GTPase, IMAP family member 4
, GTPase IMAP family member 4
, human immune associated nucleotide 1
, immunity associated protein 4
, immunity-associated nucleotide 1 protein
, immunity-associated protein 4
, immune associated nucleotide 1
, immune-associated nucleotide 1