anti-Glutaminyl-Peptide Cyclotransferase (QPCT) Antibodies

Human Glutaminyl-Peptide Cyclotransferase (QPCT) interaction partners

1. The addition of QC activity to core diagnostic CSF biomarkers may be of specific interest in clinical cases with discordant imaging and biochemical biomarker results.

2. these findings demonstrate a significant association between common single nucleotide polymorphism within QPCT gene and schizophrenia risk in a Han Chinese population.

3. the genetic risk of QPCT gene for schizophrenia also exists in the Han Chinese population.

4. observations provide evidence for an involvement of QC in Alzheimer's disease pathogenesis and cognitive decline by QC-catalyzed pGlu-Abeta formation

5. this study demonistrated that QPCT mRNAand protein from mononuclear cells correlated with theseverity of dementia.

6. Upregulation of QPCT expression is associated with thyroid carcinomas.

7. This study presents a first comparison of two mammalian QCs (human and mouse) containing typical, conserved post-translational modifications.

8. The resilts of this studt provided histopathological evidence for QC being a prerequisite for pE-Abeta pathology in vivo and further underline the therapeutic potential of QC inhibition in Alzheimer Disease.

9. Upon binding to PBD150, a large loop movement in gQC allows the inhibitor to be tightly held in its active site primarily by hydrophobic interactions.

10. This study demonstrated that glutaminyl cyclase expression and pE-Abeta formation in subcortical brain regions( Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert) affected in Alzheimer's disease.

11. Human isoQC proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.

12. Functional expression of human glutaminyl cyclase in Pichia pastoris reveals the presence of a disulfide bond with an important role in the stabilization of active protein structure.

13. human glutaminyl cyclase is a metal-dependent transferase

14. Glutaminyl cyclase was expressed as a fully active 37 kDa enzyme with kcat/Km values of 14.3, 9.3, and 2.4 mM(-1)s(-1) for the substrates Gln-Gln, Gln-NH(2), and Gln-t-butyl ester, respectively

15. Genetic variations in QPCT are important factors affecting the bone mineral density of adult women that contribute to susceptibility for osteoporosis.

16. structure of human QC in free form and bound to a substrate and three imidazole-derived inhibitors

17. Our results suggest that QPCT may be the QTL gene at chromosome 2p for spine BMD variation in the Chinese population

18. combined steady-state enzyme kinetic and X-ray structural analyses of 11 single-mutation human QCs to investigate the roles of the H-bond network in catalysis

19. The computations outline the important role of Trp329 in helping the substrate binding process and stabilizing the cyclization transition state.

20. Golgi apparatus retention implies a "housekeeping" protein maturation machinery conducting glycosylation and pyroglutamyl formation. For these isoenzymes, apparently similar strategies evolved to retain the proteins in the Golgi complex.

Mouse (Murine) Glutaminyl-Peptide Cyclotransferase (QPCT) interaction partners

1. Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5.

2. co-regulation of the enzyme glutaminyl cyclase and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta deposits

3. This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC in defined brain regions of different inbred and outbred mouse strains

4. This study presents a first comparison of two mammalian QCs (mouse and human)containing typical, conserved post-translational modifications.

5. Glutaminyl cyclase in a mouse knockout model has a role in hypothyroidism but not hypogonadism

6. QC is crucial for modulating AbetapE3-42 levels in vivo and prove on a genetic base the concept that reduction of QC activity is a promising new therapeutic approach for AD.

7. Murine isoQC proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.

8. Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development.

9. The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1, cathepsin B, and glutaminyl cyclase.

10. QC is a zinc-dependent catalyst