anti-Glutaminyl-Peptide Cyclotransferase (QPCT) Antibodies

QPCT encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. Additionally we are shipping QPCT Proteins (16) and QPCT Kits (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
QPCT 25797 Q16769
QPCT 70536 Q9CYK2
QPCT 313837  
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Top anti-QPCT Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-QPCT Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Muscle 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.52 KDa) . Dilution: 1:500~1000 Detection limit for recombinant GST tagged QPCT is approximately 0.03ng/ml as a capture antibody. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: QPCT Antibody [NBP1-81838] - Staining of human cell line A-431 shows positivity in mitochondria. Western Blot: QPCT Antibody [NBP1-81838] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY415772) 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p) 100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated WB QPCT Antibody (C-term)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the QPCT antibody detected the QPCT protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.89 KDa) . 50 μL Log in to see 11 to 12 Days
$305.71
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Human Uterus. Figure. Western Blot; Sample: Recombinant QPCT, Human. 100 μg Log in to see 13 to 16 Days
$350.00
Details
Human Rabbit Un-conjugated IP, WB QPCT MaxPab rabbit polyclonal antibody. Western Blot analysis of QPCT expression in HeLa. Immunoprecipitation of QPCT transfected lysate using anti-QPCT MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with QPCT purified MaxPab mouse polyclonal antibody (B01P) . 100 μL Log in to see 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$446.88
Details

Top referenced anti-QPCT Antibodies

  1. Human Polyclonal QPCT Primary Antibody for ELISA, WB - ABIN565166 : Morawski, Hartlage-Rübsamen, Jäger, Waniek, Schilling, Schwab, McGeer, Arendt, Demuth, Rossner: Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. in Acta neuropathologica 2010 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal QPCT Primary Antibody for WB - ABIN2565834 : Morawski, Schilling, Kreuzberger, Waniek, Jäger, Koch, Cynis, Kehlen, Arendt, Hartlage-Rübsamen, Demuth, Roßner: Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-? load and cognitive decline in Alzheimer's disease. in Journal of Alzheimer's disease : JAD 2014 (PubMed)

  3. Human Polyclonal QPCT Primary Antibody for WB - ABIN525428 : Valenti, Bolognin, Zanatta, Donatelli, Innamorati, Pampanin, Zanusso, Zatta, Dalle Carbonare: Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients. in Journal of Alzheimer's disease : JAD 2013 (PubMed)

  4. Human Polyclonal QPCT Primary Antibody for IHC, IHC (p) - ABIN4314698 : Guo, He, Liu, Zhang, Lv, Zeng, Gu, Wu: Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct. in Molecules and cells 2015 (PubMed)

More Antibodies against QPCT Interaction Partners

Human Glutaminyl-Peptide Cyclotransferase (QPCT) interaction partners

  1. The addition of QC activity to core diagnostic CSF biomarkers may be of specific interest in clinical cases with discordant imaging and biochemical biomarker results.

  2. these findings demonstrate a significant association between common single nucleotide polymorphism within QPCT gene and schizophrenia risk in a Han Chinese population.

  3. the genetic risk of QPCT gene for schizophrenia also exists in the Han Chinese population.

  4. observations provide evidence for an involvement of QC in Alzheimer's disease pathogenesis and cognitive decline by QC-catalyzed pGlu-Abeta formation

  5. this study demonistrated that QPCT mRNAand protein from mononuclear cells correlated with theseverity of dementia.

  6. Upregulation of QPCT expression is associated with thyroid carcinomas.

  7. This study presents a first comparison of two mammalian QCs (human and mouse) containing typical, conserved post-translational modifications.

  8. The resilts of this studt provided histopathological evidence for QC being a prerequisite for pE-Abeta pathology in vivo and further underline the therapeutic potential of QC inhibition in Alzheimer Disease.

  9. Upon binding to PBD150, a large loop movement in gQC allows the inhibitor to be tightly held in its active site primarily by hydrophobic interactions.

  10. This study demonstrated that glutaminyl cyclase expression and pE-Abeta formation in subcortical brain regions( Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert) affected in Alzheimer's disease.

  11. Human isoQC proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.

  12. Functional expression of human glutaminyl cyclase in Pichia pastoris reveals the presence of a disulfide bond with an important role in the stabilization of active protein structure.

  13. human glutaminyl cyclase is a metal-dependent transferase

  14. Glutaminyl cyclase was expressed as a fully active 37 kDa enzyme with kcat/Km values of 14.3, 9.3, and 2.4 mM(-1)s(-1) for the substrates Gln-Gln, Gln-NH(2), and Gln-t-butyl ester, respectively

  15. Genetic variations in QPCT are important factors affecting the bone mineral density of adult women that contribute to susceptibility for osteoporosis.

  16. structure of human QC in free form and bound to a substrate and three imidazole-derived inhibitors

  17. Our results suggest that QPCT may be the QTL gene at chromosome 2p for spine BMD variation in the Chinese population

  18. combined steady-state enzyme kinetic and X-ray structural analyses of 11 single-mutation human QCs to investigate the roles of the H-bond network in catalysis

  19. The computations outline the important role of Trp329 in helping the substrate binding process and stabilizing the cyclization transition state.

  20. Golgi apparatus retention implies a "housekeeping" protein maturation machinery conducting glycosylation and pyroglutamyl formation. For these isoenzymes, apparently similar strategies evolved to retain the proteins in the Golgi complex.

Mouse (Murine) Glutaminyl-Peptide Cyclotransferase (QPCT) interaction partners

  1. Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5.

  2. co-regulation of the enzyme glutaminyl cyclase and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta deposits

  3. This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC in defined brain regions of different inbred and outbred mouse strains

  4. This study presents a first comparison of two mammalian QCs (mouse and human)containing typical, conserved post-translational modifications.

  5. Glutaminyl cyclase in a mouse knockout model has a role in hypothyroidism but not hypogonadism

  6. QC is crucial for modulating AbetapE3-42 levels in vivo and prove on a genetic base the concept that reduction of QC activity is a promising new therapeutic approach for AD.

  7. Murine isoQC proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.

  8. Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development.

  9. The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1, cathepsin B, and glutaminyl cyclase.

  10. QC is a zinc-dependent catalyst

QPCT Antigen Profile

Protein Summary

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.

Gene names and symbols associated with QPCT

  • glutaminyl-peptide cyclotransferase (QPCT) antibody
  • glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (Qpct) antibody
  • glutaminyl-peptide cyclotransferase (M6_Spy0443) antibody
  • glutaminyl-peptide cyclotransferase (M5005_Spy_0416) antibody
  • glutaminyl-peptide cyclotransferase (M28_Spy0404) antibody
  • glutaminyl-peptide cyclotransferase (CJA_2408) antibody
  • glutaminyl-peptide cyclotransferase (CCNA_02733) antibody
  • glutaminyl-peptide cyclotransferase (Tsp_03182) antibody
  • glutaminyl-peptide cyclotransferase (Qpct) antibody
  • glutaminyl-peptide cyclotransferase L homeolog (qpct.L) antibody
  • 5730422A13Rik antibody
  • GCT antibody
  • QC antibody
  • qpct antibody
  • Qpctl1 antibody
  • RGD1562284 antibody
  • sQC antibody

Protein level used designations for QPCT

EC , glutaminyl cyclase , glutaminyl-tRNA cyclotransferase , glutamyl cyclase , glutaminyl-peptide cyclotransferase (glutaminyl cyclase) , QC , glutaminyl-peptide cyclotransferase , glutaminyl-peptide cyclotransferase-like 1 , glutaminyl-peptide cyclotransferase L homeolog

GENE ID SPECIES
25797 Homo sapiens
397424 Sus scrofa
281437 Bos taurus
403861 Canis lupus familiaris
421479 Gallus gallus
744549 Pan troglodytes
70536 Mus musculus
2942628 Streptococcus pyogenes MGAS10394
3572510 Streptococcus pyogenes MGAS5005
3574689 Streptococcus pyogenes MGAS6180
6415865 Cellvibrio japonicus Ueda107
7330894 Caulobacter crescentus NA1000
10908433 Trichinella spiralis
100217805 Taeniopygia guttata
100718225 Cavia porcellus
313837 Rattus norvegicus
447416 Xenopus laevis
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