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GGA1 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Additionally we are shipping GGA1 Antibodies (69) and and many more products for this protein.
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novel protein complex composed of Rabep1, GGA1 and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 Proteins) andpolycystin 2 to the cilium.
GGA1 interacts with internal LRP9 (show LRP10 Proteins) and LRP12 (show LRP12 Proteins) DXXLL motifs.
depletion of GGA1 and GGA3 (show GGA3 Proteins) engender a rapid and robust elevation of BACE1 (show BACE Proteins) in the acute phase after brain injury.
termination of Arf1 (show ARF1 Proteins) signals mediated through GGA require that Arf1 (show ARF1 Proteins).GTP (show AK3 Proteins) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (show AK3 Proteins)
serine phosphorylation of BACE (show BACE Proteins) is a physiologically relevant post-translational modification that regulates trafficking in the juxtanuclear compartment by interaction with GGA1
Glut4 (show SLC2A4 Proteins) insulin (show INS Proteins)-responsive trafficking is mediated by GGA adaptors in mouse adipocytes
the trafficking of adiponectin through its secretory pathway is dependent on GGA-coated vesicles
full length alpha2B (show ADRA2B Proteins)-AR associated with GGA2 (show GGA2 Proteins) but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2 (show GGA2 Proteins). More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 (show GGA2 Proteins) GAE domain bound to multiple subdomains of the loop.
These findings show that the AD-like phenotype of NPC (show NPC1 Proteins) model cells can be partly reverted by promoting a non-amyloidogenic processing of APP (show APP Proteins) through the upregulation of GGA1 supporting its preventive role against AD
These data indicate that clathrin is required for the function of AP-1 (show FOSB Proteins)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.
On basis of these results, propose that GGA1 facilitates LR11 (show SORL1 Proteins) endocytic traffic and that LR11 (show SORL1 Proteins) modulates A-beta (show SUCLA2 Proteins) levels by promoting amyloid-beta precursor protein traffic to the endocytic recycling compartment
X-ray structure of the GGA1 VHS domain alone, and in complex with the carboxy-terminal peptide of cation-independent mannose 6-phosphate receptor (show IGF2R Proteins) containing an ACLL sequence
endocytosis and intracellular transport of memapsin 2 (show BACE Proteins), mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2 (show GGA2 Proteins)
The 2.4-A crystal structure of the GAT domain of human GGA1 reveals a three-helix bundle, with a long N-terminal helical extension that is not conserved in GAT domains that do not bind ARF.
X-ray crystal structures of the human GGA1-GAT domain and the complex between ARF1-GTP and the N-terminal region of the GAT domain
Crystal structure of the human GGA1 GAT domain
A hydrophobic surface patch on the C-terminal three-helix bundle motif of the GGA1 GAT domain is directly involved in binding with a coiled-coil region of rabaptin-5.
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
golgi associated gamma adaptin ear containing arf binding protein 1 (gga1)
, ADP-ribosylation factor-binding protein GGA1
, gamma-adaptin-related protein 1
, golgi-localized, gamma ear-containing, ARF-binding protein 1
, ADP-ribosylation factor binding protein 1
, gamma-adaptin related protein 1
, golgi associated, gamma adaptin ear containing, ARF binding protein 1