anti-Hairy and Enhancer of Split 6 (Drosophila) (HES6) Antibodies

HES6 encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Additionally we are shipping Hairy and Enhancer of Split 6 (Drosophila) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HES6 55927 Q9JHE6
HES6 55502 Q96HZ4
HES6 316626  
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Top anti-Hairy and Enhancer of Split 6 (Drosophila) Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Hes6 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Stomach 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa cells, using HES6 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Dog Rabbit Un-conjugated IHC, WB Human Pancreas WB Suggested Anti-HES6 Antibody Titration:  1.25ug/ml  Positive Control:  Transfected 293T 100 μL 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of HES6 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of HES6 expression in HepG2 (A), HeLa (B), MCF7 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of HES6 Antibody (N-term) in MCF-7 cell line lysates (35ug/lane). HES6 (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Details
Dog Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
$493.17
Details
Human Mouse Un-conjugated WB 100 μL 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of HES6 using LOVO whole cell lysates ABIN6278578 staining MCF7 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL 11 to 12 Days
$390.77
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details

More Antibodies against Hairy and Enhancer of Split 6 (Drosophila) Interaction Partners

Zebrafish Hairy and Enhancer of Split 6 (Drosophila) (HES6) interaction partners

  1. the PT enhancer with the 3'UTR of hes6 responded to the inhibition of retinoic acid synthesis and fibroblast growth factor signaling in a manner similar to endogenous hes6.

  2. hes6, the clock gene that does not oscillate, responds to negative feedback

  3. Data define a network of Her/Hes dimers underlying transcriptional negative feedback within the zebrafish segmentation clock, where Her7 acts directly within the delayed negative feedback as a DNA-binding heterodimer with Hes6.

  4. Forms specific heterodimers with her1, which may directly be required for regulating further target genes.

Mouse (Murine) Hairy and Enhancer of Split 6 (Drosophila) (HES6) interaction partners

  1. Hes6 is involved in the regulation of neuroblast differentiation during adult neurogenesis, but does not influence integration into mature neurons.

  2. Hes6 physically and functionally interacts with RelA-containing NF-kappaB complexes in cortical progenitor cells to control cortical neurogenesis.

  3. Hes6 regulates myogenic differentiation.

  4. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity.

  5. Hes6 is a regulator of the neurogenic phase of cortical development by promoting neuronal fate while suppressing astrocyte differentiation.

  6. ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter

  7. Data reveal a role for Ascl1 in the regulation of Hes6, a proneurogenic factor that inhibits Notch signaling to promote neural rather than glial differentiation

Human Hairy and Enhancer of Split 6 (Drosophila) (HES6) interaction partners

  1. High HES6 expression is associated with metastasis in colorectal cancer.

  2. prostate cancer-specific up-regulation of NOTCH3 and HES6, is reported.

  3. HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer.

  4. HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1.

  5. HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility.

  6. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.

  7. Data suggest that Hes-6 is a potential oncogene overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells.

  8. Differentially expressed in metastatic colon carcinoma

  9. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity.

  10. Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation.

  11. Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin expression

  12. Increased expression of Notch3, Jagged1, Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells.

  13. ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter

  14. the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and -independent pathways.

  15. These four variants were tested for association with mood disorder diagnosis or antidepressant response in a family study of depression, but no significant associations were observed.

Hairy and Enhancer of Split 6 (Drosophila) (HES6) Antigen Profile

Protein Summary

This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with HES6

  • hes family bHLH transcription factor 6 (hes6) antibody
  • hairy and enhancer of split 6 (Hes6) antibody
  • hes family bHLH transcription factor 6 (HES6) antibody
  • hes family bHLH transcription factor 6 (Hes6) antibody
  • AI326893 antibody
  • bHLHb41 antibody
  • bHLHc23 antibody
  • her13.2 antibody
  • HES-6 antibody
  • YF-30 antibody

Protein level used designations for HES6

hairy and enhancer of split 6 , transcription cofactor HES-6 , C-HAIRY1 , class B basic helix-loop-helix protein 41

GENE ID SPECIES
373116 Danio rerio
55927 Mus musculus
55502 Homo sapiens
316626 Rattus norvegicus
531384 Bos taurus
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