HES6 antibody (C-Term)

Catalog No. ABIN2777651

The Rabbit Polyclonal anti-HES6 antibody is suitable to detect HES6 in samples from Human, Mouse, Rat and Dog. It has been validated for WB and IHC.

Quick Overview for HES6 antibody (C-Term) (ABIN2777651)

Target: HES6 (Hairy and Enhancer of Split 6 (HES6))

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HES6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-HES6 Antibody

Binding Specificity: C-Term

Purpose: HES6 Antibody - C-terminal region

Sequence: PPGPGDDLCS DLEEAPEAEL SQAPAEGPDL VPAALGSLTT AQIARSVWRP

Predicted Reactivity: Dog: 86%, Human: 100%, Mouse: 79%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against HES6. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HES6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8102163

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HES6

Target: HES6 (Hairy and Enhancer of Split 6 (HES6))

Alternative Name: HES6

Background:

Background Information: HES6 belongs to a subfamily of basic helix-loop-helix transcription factors that includes Drosophila Hairy and Enhancer of split genes. Like other members of the family, HES6 features the WRPW motif which is consisted just of four amino acids at its C-terminus. It is expressed by both undifferentiated and differentiated cells and is an inhibitor of Hes1. HES6 supports Mash1 activity and promotes cell differentiation.

Gene Name: Hairy and enhancer of split 6 (Drosophila)

Alternative Symbols: HES-6, bHLHb41, bHLHc23, C-HAIRY1

Protein Name: Transcription cofactor HES-6

Molecular Weight: 25kDa

Gene ID: 55502

NCBI Accession: NP_061115

UniProt: Q96HZ4