anti-Hect Domain and RLD 2 (HERC2) Antibodies

Mouse (Murine) Hect Domain and RLD 2 (HERC2) interaction partners

1. identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33.

2. HERC2 acts as a regulator of E6AP.

Human Hect Domain and RLD 2 (HERC2) interaction partners

1. HERC2 is a master regulator of G-quadruplex, a DNA secondary structure that triggers genomic instability, through BLM, WRN, and RPA, and may serve as a potential molecular target in cancer therapy

2. The results of this study are the first to show an association between HERC2 variants and time to first cSCC post-transplant.

3. By downregulating acetylated LKB1 protein via HERC2, SIRT1 fine-tunes the crosstalk between endothelial and vascular smooth muscle cells to prevent adverse arterial remodeling and maintain vascular homeostasis

4. Evaluated the association of seven OCA2-HERC2 SNPs and haplotypes with pigmentation characteristics (eye, skin, hair and freckles) in the highly admixed and phenotypically heterogeneous Brazilian population. Such SNPs and haplotypes could be deemed as good predictors for the presence of freckles and for skin, eye and hair pigmentation in the Brazilian population.

5. We showed that loss of HERC2 function leads to the accumulation of XPA and BRCA1 in the patient's fibroblasts and generates decreased sensitivity to apoptosis and increased level of DNA repair

6. SNP rs12913832 in HERC2 was found to be strongly associated with blue eye colour. SNP associations with hair and skin colour were weaker and genotypes less predictive.

7. Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.

8. Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal.

9. Results identify HERC2 as a regulator of p53 signaling.

10. results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism

11. identified HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33.

12. ATR-mediated phosphorylation induces XPA stabilization by antagonizing HERC2-catalyzed XPA ubiquitination.

13. given a particular HERC2/OCA2 genotype, males are more prone to have lighter eye colors than predicted by their genotypes, while females tend to have darker eye colors than predicted

14. Studied an autosomal-recessive neurodevelopmental disorder with some phenotypic similarities to Angelman syndrome, found among the Old Order Amish. Our molecular investigation identified a mutation in HERC2 associated with the disease phenotype.

15. Pathogenic changes in HERC2 are associated with nonsyndromic intellectual disability, autism, and gait disturbance.

16. the NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture

17. HERC2 rs12913832 region functions as an enhancer regulating OCA2 transcription.

18. In response to double-strand breaks, both HERC2 and RNF168 were specifically modified with SUMO1 at double-strand break sites in a manner dependent on the SUMO E3 ligase PIAS4.

19. we found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability

20. These results suggest that HERC2 regulates DNA replication progression and origin firing by facilitating MCM2 phosphorylation.