anti-HtrA Serine Peptidase 3 (HTRA3) Antibodies

Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Additionally we are shipping HtrA Serine Peptidase 3 Kits (16) and HtrA Serine Peptidase 3 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HTRA3 94031 P83110
HTRA3 78558 Q9D236
HTRA3 360959 D3ZA76
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Top anti-HtrA Serine Peptidase 3 Antibodies at

Showing 10 out of 31 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Dog Rabbit Un-conjugated WB 100 μL 2 to 3 Days
Human Rabbit Un-conjugated WB Western blot analysis of HtrA3 using anti- HtrA3 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.    Lane 1: PANC-1 whole Cell lysates,   Lane 2: HEPG2 whole cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- HtrA3 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for HtrA3 at approximately 49KD. The expected band size for HtrA3 is at 49KD. 100 μg 4 to 6 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Liver (formalin-fixed, paraffin-embedded) stained with HTRA3 antibody ABIN296848 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-HTRA3 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg 11 to 14 Days
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated IHC (p), WB 50 μg 6 to 8 Days
Human Rabbit Un-conjugated IHC (p), WB Western Blot at 1:1000 dilution + human heart lysate Lysates/proteins at 20 ug per lane. Antibody is used in Western blot to detect HtrA3 in rat testis tissue lysate. 400 μL 2 to 3 Days
Gibbon Rabbit Un-conjugated IHC, WB 0.05 mg 2 to 3 Days
Guinea Pig Rabbit Un-conjugated WB   100 μL 11 to 14 Days
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using HTRA3 antibody. 200 μL 12 to 14 Days
Human Mouse Un-conjugated ELISA, WB HTRA3 monoclonal antibody (M03), clone 1F2. Western Blot analysis of HTRA3 expression in A-431. Detection limit for recombinant GST tagged HTRA3 is 1 ng/ml as a capture antibody. 100 μg 11 to 12 Days

Top referenced anti-HtrA Serine Peptidase 3 Antibodies

  1. Human Polyclonal HTRA3 Primary Antibody for ICC, IF - ABIN269353 : Beleford, Rattan, Chien, Shridhar: High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against HtrA Serine Peptidase 3 Interaction Partners

Rhesus Monkey HtrA Serine Peptidase 3 (HTRA3) interaction partners

  1. HTRA3 may be involved in folliculogenesis and luteinisation in the primate ovary. HTRA3 is possibly a factor involved in and potentially important for primate placentation.

Human HtrA Serine Peptidase 3 (HTRA3) interaction partners

  1. The HtrA1-PDZ and HtrA4-PDZ as well as HtrA2-PDZ and HtrA3-PDZ respond similarly to different halogen substitutions of peptide; -Br substitution at R2-position and -I substitution at R4-position are most effective in improving peptide selectivity for HtrA1-PDZ/HtrA4-PDZ and HtrA2-PDZ/HtrA3-PDZ, respectively; -F substitution would not address substantial effect on peptide selectivity for all the 4 domains

  2. results indicate that actin, beta-tubulin, vimentin, and TCP1alpha are HtrA3 cellular partners and suggest that HtrA3 may influence cytoskeleton dynamics.

  3. Hypoxia is responsible for the reduction of HtrA3 which in turn promotes endometrial cancer progression.

  4. Study demonstrated that in women serum levels of HtrA3 during early pregnancy were significantly lower in IUGR pregnancies, establishing an association between lower HtrA3 levels and placental insufficiency.

  5. Our findings demonstrated a novel pro-apoptotic role of HTRA3 in pancreatic cancer cells via inducing Bax.

  6. HTRA3 suppresses tumor cell invasiveness and may serve as a prognostic biomarker for postoperative recurrence or survival in NSCLC

  7. Removal of the 6 additional LB loop residues caused a complete loss of the proper trimeric structure. Impairing their interactions with the PDZ domain decreased the amount of the trimers. The LB loop helps stabilize the DeltaN-HtrA3L oligomer structure suggesting involvement of the LB-PDZ interactions in the stabilization. A monomeric form of the DeltaN-HtrA3L is proteolytically inactive.

  8. HtrA3 expression in the peritumoral stroma of patients with stage II colorectal cancer is associated with high-grade tumor budding and may be a novel marker of poor outcome.

  9. New insights into the structure and function of DeltaN-HtrA3, which seems to have a unique combination of features among human HtrA proteases.

  10. HtrA3 is likely to be associated with the acquisition of the invasive phenotype in oral squamous cell carcinoma cells and may be a potential prognostic marker for oral cance

  11. HtrA1 and HtrA3 are crucial for trophoblast-decidual cell interaction in the control of trophoblast invasion.

  12. Data indicate that the levels of high temperature requirement factor A3 (HtrA3)protein were lower in all subtypes of ovarian cancer and the lowest levels of HtrA3 were in epithelial ovarian cancer.

  13. Data indicate that in breast cancers with no lymphatic metastasis, the expression of HtrA3 was lower in patients with estrogen receptor (ER)- and progesterone receptor (PR)-positive tumors.

  14. HtrA3 may have a role as an early marker for preeclampsia

  15. results suggest that HtrA3 variants may play different roles in cancer development, and that the increased HtrA3-L levels in thyroid tissue could be correlated with the development of malignant lesions

  16. HTRA3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.

  17. decidual HtrA3 negatively regulates trophoblast invasion

  18. inhibitor of trophoblast invasion during placental development

  19. Abnormally high levels of serum HtrA3 at approximately 13-14 wk of gestation is associated with preeclampsia

  20. role of HtrA3 (along with HtrA1 and HtrA2) in development/progression of cancer, neurodegenerative disorders and arthritic diseases [REVIEW]

Mouse (Murine) HtrA Serine Peptidase 3 (HTRA3) interaction partners

  1. Results show that HtrA3 deletion in the mother resulted in intra-uterine growth restriction (IUGR). Disorganization of labyrinthine fetal capillaries was the major placental defect when HtrA3 was absent. Mice born to HtrA3-deficient mothers, independent of their own genotype, were significantly heavier and contained a larger mass of white fat.

  2. Plays an important role in the formation/function of the placenta.

  3. Both mRNA and protein of HtrA3 were localized specifically in the maternal decidua. Only the maternal decidual cells, but not blood vessels or uterine NK cells that are present in large numbers, were positive for HtrA3.

HtrA Serine Peptidase 3 (HTRA3) Antigen Profile

Protein Summary

Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity).

Gene names and symbols associated with HTRA3

  • Trypsin-like serine protease (htrA3) antibody
  • HtrA serine peptidase 3 (HTRA3) antibody
  • HtrA serine peptidase 3 (Htra3) antibody
  • 2210021K23Rik antibody
  • 9530081K03Rik antibody
  • HTRA3 antibody
  • Prsp antibody
  • RGD1308120 antibody
  • Tasp antibody

Protein level used designations for HTRA3

Trypsin-like serine protease , HtrA serine peptidase 3 , probable serine protease HTRA3-like , high-temperature requirement factor A3 , pregnancy-related serine protease , probable serine protease HTRA3 , serine protease HTRA3 , toll-associated serine protease

9283730 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1
722638 Macaca mulatta
100393858 Callithrix jacchus
94031 Homo sapiens
78558 Mus musculus
360959 Rattus norvegicus
100716678 Cavia porcellus
100337673 Sus scrofa
100687287 Canis lupus familiaris
100336523 Bos taurus
422868 Gallus gallus
101119395 Ovis aries
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