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HTRA3 Products

(HtrA Serine Peptidase 3 (HTRA3))
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity).

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Featured HTRA3 Categories

HTRA3 Antibodies

High quality antibodies with extensive validation data.

HTRA3 ELISA Kits

Reliable ELISA kits for a wide range of species.

HTRA3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HTRA3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application WB, IHC (p)
Validations
  • (3)
  • (4)
Cat. No. ABIN1882095
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN949792
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, ELISA
Validations
  • (1)
Cat. No. ABIN7238582
Quantity 200 μL
Datasheet Datasheet

Recommended HTRA3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Pig
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN779001
Quantity 96 tests
Datasheet Datasheet
Reactivity Goat
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN992897
Quantity 96 tests
Datasheet Datasheet
Reactivity Dog
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN992898
Quantity 96 tests
Datasheet Datasheet

Recommended HTRA3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123367
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307287
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our HTRA3 products

Dynon, Heng, Puryer, Li, Walton, Endo, Nie: "HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening." in: PLoS ONE, Vol. 7, Issue 9, pp. e45956, (2012) (PubMed).

Beleford, Rattan, Chien, Shridhar: "High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12011-27, (2010) (PubMed).

Narkiewicz, Klasa-Mazurkiewicz, Zurawa-Janicka, Skorko-Glonek, Emerich, Lipinska: "Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer." in: Clinical biochemistry, Vol. 41, Issue 7-8, pp. 561-9, (2008) (PubMed).

Grau, Baldi, Bussani, Tian, Stefanescu, Przybylski, Richards, Jones, Shridhar, Clausen, Ehrmann: "Implications of the serine protease HtrA1 in amyloid precursor protein processing." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 17, pp. 6021-6, (2005) (PubMed).

Nie, Hampton, Li, Findlay, Salamonsen et al.: "Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and ..." in: The Biochemical journal, Vol. 371, Issue Pt 1, pp. 39-48, (2003) (PubMed).

Synonyms and alternative names related to HTRA3

Trypsin-like serine protease (htrA3), HtrA serine peptidase 3 (HTRA3), HtrA serine peptidase 3 (Htra3), 2210021K23Rik, 9530081K03Rik, HTRA3, Prsp, RGD1308120, Tasp

Protein level used designations for HTRA3

  • Trypsin-like serine protease
  • HtrA serine peptidase 3
  • probable serine protease HTRA3-like
  • high-temperature requirement factor A3
  • pregnancy-related serine protease
  • probable serine protease HTRA3
  • serine protease HTRA3
  • toll-associated serine protease
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