anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) Antibodies

HSD17B10 encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. Additionally we are shipping HSD17B10 Proteins (20) and HSD17B10 Kits (19) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HSD17B10 3028 Q99714
HSD17B10 15108  
HSD17B10 63864 O70351
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Top anti-HSD17B10 Antibodies at antibodies-online.com

Showing 10 out of 144 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN185330 staining (0.3µg/ml) of Human Brain lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- ERAB Picoband antibody,IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg 4 to 6 Days
$280.00
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Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image ERAB antibody detects ERAB protein at mitochondria on mouse intestine by immunohistochemical analysis. Sample: Paraffin-embedded mouse intestine. ERAB antibody , dilution: 1:500. WB Image Sample (30 ug of whole cell lysate)    A: PC-12   12% SDS PAGE    antibody diluted at 1:5000   100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry on Formalin-fixed and paraffin-embedded human prostate tissue. (Top)Coloration with the Anti-ABAD antibody at a 1:20 concentration. (Bottom)Antibody adsorbed to the antigen (peptide), negative control.Disappearance of cytoplasmic staining indicating the antibody is specific. Western blot analysis of anti-ABAD Pab in mouse kidney tissue lysate.ABAD(arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB 100 μg 2 to 3 Days
$245.00
Details
Cow Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of HADH2 staining in SKNSH cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of HADH2 staining in human lung formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from LOVO cells, using ERAB Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ERAB Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-ABAD Pab (ABIN390286) in mouse kidney tissue lysate.ABAD(arrow) was detected using the purified polyclonal antibody. Immunohistochemistry on Formalin-fixed and paraffin-embedded human prostate tissue. (Top)Coloration with the Anti-ABAD antibody at a 1:20 concentration. (Bottom)Antibody adsorbed to the antigen (peptide), negative control.Disappearance of cytoplasmic staining indicating the antibody is specific. Data and protocol courtesy of Marie-Hélène Levesque, Centre de Recherche du CHUL, Canada. 400 μL 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details

Top referenced anti-HSD17B10 Antibodies

  1. Human Polyclonal HSD17B10 Primary Antibody for IHC (p), ELISA - ABIN545826 : Lustbader, Cirilli, Lin, Xu, Takuma, Wang, Caspersen, Chen, Pollak, Chaney, Trinchese, Liu, Gunn-Moore, Lue, Walker, Kuppusamy, Zewier, Arancio, Stern, Yan, Wu: ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. in Science (New York, N.Y.) 2004 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal HSD17B10 Primary Antibody for ELISA, WB - ABIN268653 : Tilton, Haidacher, Lejeune, Zhang, Zhao, Kurosky, Brasier, Denner: Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry. in Proteomics 2007 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal HSD17B10 Primary Antibody for IF, WB - ABIN516335 : Kristofiková, Bocková, Hegnerová, Bartos, Klaschka, Rícný, Rípová, Homola: Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis. in Molecular bioSystems 2009 (PubMed)

  4. Human Polyclonal HSD17B10 Primary Antibody for ELISA, WB - ABIN185330 : He, Schulz, Yang: A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease. in The Journal of biological chemistry 1998 (PubMed)
    Show all 4 Pubmed References

More Antibodies against HSD17B10 Interaction Partners

Human Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) interaction partners

  1. This study proposes low-resolution models of the MRPP1-MRPP2 and MRPP1-MRPP2-MRPP3 complexes that suggest the overall architecture, stoichiometry, and orientation of subunits and tRNA substrates.

  2. 17beta-Hydroxysteroid dehydrogenase type 10 is a multifunctional, homotetrameric, mitochondrial protein encoded by the HSD17B10 gene at Xp 11.2. This protein, 17beta-HSD10, is overexpressed in brain cells of Alzheimer's disease (AD) patients. Analysis of the impact of 17beta-HSD10 and its inhibitor, amyloid-beta peptide (Abeta), on the metabolism of neuroactive steroids offers a new approach to AD pathogenesis.

  3. Authors report two patients with novel missense mutations in the HSD17B10 gene (c.34G>C and c.526G>A), resulting in the p.V12L and p.V176M substitutions. Val12 and Val176 are highly conserved residues located at different regions of the MRPP2 structure.

  4. in addition to being an essential component of the RNase P reaction, MRPP1/2 serves as a processing platform for several down-stream tRNA maturation steps in human mitochondria.

  5. The S-nitrosation of a cysteine residue distal to the 3-hydroxyacyl-CoA dehydrogenase type 2 (HADH2) active site impaired catalytic activity.

  6. A computational study and enzyme inhibition assay with full length human 17-beta-HSD10 identifies risperidone as enzyme inhibitor and possible antineoplastic agent.

  7. Data suggest that HSD10 plays a role in alterations of energy metabolism by regulating mtDNA content in colorectal carcinomas.

  8. upon exposure to E2, ERalpha rapidly localizes to mitochondria, in which it interacts with HSD17B10 to modulate the expression of mitochondrial RNA transcripts.

  9. Our findings demonstrate that overexpression of HSD10 accelerates pheochromocytoma cell growth, enhances cell respiration, and increases cellular resistance to cell death induction.

  10. Three HSD10 variants associated with neurodegenerative disorders are inactive with cardiolipin

  11. The authors demonstrate elevated amounts of unprocessed pre-tRNAs and mRNA transcripts encoding mitochondrial subunits indicating deficient RNase P activity in HSD10 disease.

  12. The study showed that pathogenic mutations impair SDR5C1-dependent dehydrogenation, tRNA processing and methylation.

  13. loss of HSD10 causes impaired mitochondrial precursor transcript processing which may explain mitochondrial dysfunction observed in HSD10 disease

  14. Defects in this gene are a cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. The encoded protein does not exhibit generalized alcohol dehydrogenase activity as was previously thought.

  15. Significantly higher levels of SRD5A1, AKR1C2, AKR1C3, and HSD17B10 mRNA were however found in bone metastases than in non-malignant and/or malignant prostate tissue

  16. Inhibition of mitochondrial RNase P by beta-amyloid is an unspecific effect and is not mediated by beta-amyloid interaction with SDR5C1.

  17. Two major HSD17B10 transcription start sites were identified by primer extension at -37 and -6 as well as a minor start site at -12 nucleotides from the initiation codon ATG.

  18. A 5-methylcytosine is present in both active and inactive X chromosomes at + 2259 nucleotide from the initiation ATG of the HSD17B10 gene, explaining the prevalence of the p.R130C mutation among HSD10 deficiency patients.

  19. analysis of clinical consequences of mutations in the HSD17B10 gene

  20. The role of ABAD in amyloid beta toxicity, was investigated.

Mouse (Murine) Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) interaction partners

  1. Data show that donor engraftment is necessary for BMT-mediated reduction in age-related amyloid plaque formation in prostaglandin E2 receptor subtype 2-null mice, and that this is accompanied by reduced neurotoxic forms of amyloid peptides.

  2. that 17beta-HSD-10 is a major product of both fetal and adult-type Leydig cells.

  3. ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction.Amyloid-beta peptide (Abeta) binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, is a cofactor facilitating Abeta-induced cell stress.

HSD17B10 Antigen Profile

Protein Summary

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Gene names and symbols associated with HSD17B10

  • hydroxysteroid (17-beta) dehydrogenase 10 (HSD17B10) antibody
  • hydroxysteroid (17-beta) dehydrogenase 10 (hsd17b10) antibody
  • hydroxysteroid 17-beta dehydrogenase 10 (HSD17B10) antibody
  • hydroxysteroid (17-beta) dehydrogenase 10 L homeolog (hsd17b10.L) antibody
  • hydroxysteroid (17-beta) dehydrogenase 10 (Hsd17b10) antibody
  • 17b-HSD10 antibody
  • 17bHSD10 antibody
  • ABAD antibody
  • Ads9 antibody
  • CAMR antibody
  • DUPXp11.22 antibody
  • ERAB antibody
  • Hadh2 antibody
  • HCD2 antibody
  • hsd10 antibody
  • HSD17B10 antibody
  • im:6899159 antibody
  • MHBD antibody
  • MRPP2 antibody
  • MRX17 antibody
  • MRX31 antibody
  • MRXS10 antibody
  • SCHAD antibody
  • SDR5C1 antibody
  • wu:fj61f03 antibody
  • zgc:101605 antibody

Protein level used designations for HSD17B10

hydroxysteroid (17-beta) dehydrogenase 10 , 3-hydroxyacyl-CoA dehydrogenase type-2 , hydroxyacyl-Coenzyme A dehydrogenase, type II , 3-hydroxy-2-methylbutyryl-CoA dehydrogenase , AB-binding alcohol dehydrogenase , amyloid-beta peptide binding alcohol dehydrogenase , endoplasmic reticulum-associated amyloid beta-peptide-binding protein , mitochondrial RNase P subunit 2 , mitochondrial ribonuclease P protein 2 , short chain L-3-hydroxyacyl-CoA dehydrogenase type 2 , short chain dehydrogenase/reductase family 5C, member 1 , short chain type dehydrogenase/reductase XH98G2 , 17-beta-HSD 10 , 17-beta-hydroxysteroid dehydrogenase 10 , 3-hydroxyacyl-CoA dehydrogenase type II , hydroxyacyl-Coenzyme A dehydrogenase type II , mitochondrial RNase P protein 2 , type II HADH , amyloid beta-peptide binding protein , short chain L-3-hydroxyacyl-CoA dehydrogenase , hydroxyacyl-Coenzyme A dehydrogenase, type II hydroxyacyl-Coenzyme A

GENE ID SPECIES
425758 Gallus gallus
450078 Danio rerio
549265 Xenopus (Silurana) tropicalis
465649 Pan troglodytes
480930 Canis lupus familiaris
100342235 Oryctolagus cuniculus
3028 Homo sapiens
446903 Xenopus laevis
15108 Mus musculus
63864 Rattus norvegicus
281809 Bos taurus
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