Inducible T-Cell Co-Stimulator Proteins (ICOS)

The protein encoded by ICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. Additionally we are shipping ICOS Antibodies (123) and ICOS Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ICOS 54167 Q9WVS0
ICOS 29851 Q9Y6W8
ICOS 64545 Q9R1T7
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Top ICOS Proteins at

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
HEK-293 Cells Human Fc Tag,His tag Validation with Western Blot 20 μg Log in to see 6 to 10 Days
Mammalian Cells Mouse His tag   10 μg Log in to see 4 Days
Yeast Dog His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HEK-293 Cells Human Fc Tag   10 μg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days

ICOS Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human ,
, ,
Rat (Rattus) ,

More Proteins for Inducible T-Cell Co-Stimulator (ICOS) Interaction Partners

Mouse (Murine) Inducible T-Cell Co-Stimulator (ICOS) interaction partners

  1. Data show that inducible T cell co-stimulator (ICOS) deficient mice have a significant increase in the population of IL-17 (show IL17A Proteins)-producing Vgamma2+ gammadelta T cells in the thymus, spleen, lymph nodes and skin and exhibit exacerbated sensitization responses to 2,4-dinitrofluorobenzene.

  2. Our results indicate that ICOS regulates the ontogeny and homeostasis of B6.Sle1 lupus prone mouse T follicular helper (TFH) cells and influences the function of TFH cells during aberrant germinal center B cell responses

  3. The expression of ICOSL (show ICOSLG Proteins) in the cornea and the ICOS-mediated induction of Foxp3 (show FOXP3 Proteins)+ CD4 (show CD4 Proteins)+ regulatory T cells may contribute to successful corneal allograft survival.

  4. this study reveals a previously unknown ICOS-TBK1 (show TBK1 Proteins) signaling pathway that specifies the commitment of germinal center follicular helper T cells

  5. IFNAR1 (show IFNAR1 Proteins)-deficiency accelerated humoral immune responses and parasite control by boosting ICOS-signalling in two non-lethal murine models of malaria

  6. Fecal levels of Crp1 (show CRIP1 Proteins) were significantly decreased in mice with graft-versus-host disease and were correlated with intestinal flora diversity.

  7. IL-10 (show IL10 Proteins) production by CD4 (show CD4 Proteins)(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 (show IL27 Proteins) receptor signaling that is supported after CD4 (show CD4 Proteins)(+) T cell priming by ICOS signaling.

  8. these data suggest ICOS is not required for follicular Th cell induction during Plasmodium chabaudi chabaudi AS infection

  9. the ICOS signaling has a regulatory effect on CD154 (show CD40LG Proteins)/CD40 (show CD40 Proteins) expressions, and may play an important role in the hepatic egg granuloma formation of schistosomiasis.

  10. data identify a role of ICOS in innate immunity and indicate that not only cytokines, but also costimulatory pathways such as those involving ICOS, can contribute to regulate the ILC2 pool.

Human Inducible T-Cell Co-Stimulator (ICOS) interaction partners

  1. OX40 (show TNFRSF4 Proteins) and ICOS (show CTLA4 Proteins) act in a cooperative, nonredundant manner to maximize and prolong the T follicular helper cell response that is generated after acute virus infection

  2. High ICOS (show CTLA4 Proteins) expression is associated with colorectal neoplasms.

  3. This is the first replication association study of rs4325730 upstream of ICOS (show CTLA4 Proteins) with AIH in the Japanese population and rs4325730G is a risk allele.

  4. the induction pathway of ICOS (show CTLA4 Proteins)(+) Foxp3 (show FOXP3 Proteins)(+) cells was analyzed

  5. ratio of ICOS (show CTLA4 Proteins)(+) /PD-1 (show PDCD1 Proteins)(+) Tfh cells and the frequency of IL-21 (show IL17C Proteins)(+) Tfh cells may be indicators for evaluating the idiopathic membranous nephropathy development

  6. The ICOS (show CTLA4 Proteins) and ICOSL (show ICOSLG Proteins) SNPs examined do not have an apparent effect on the disease susceptibility and prognosis of autoimmune thyroid diseases.

  7. Follicular helper T cells differentiation is a multistage process involving BCL6 (show BCL6 Proteins) and other transcription factors, cytokines, and costimulation through ICOS (show CTLA4 Proteins) and several other molecules. (Review)

  8. findings show Tregs from inflamed lung of sarcoidosis patients characterized by ICOS (show CTLA4 Proteins)(high) phenotype; high-level ICOS (show CTLA4 Proteins) expression was restricted to Tregs from inflamed lung and was absent in blood Tregs of sarcoidosis patients and in lung and blood Tregs of healthy volunteers; potential implication of ICOS/ICOS (show CTLA4 Proteins)-L (show ICOSLG Proteins) immune-regulatory axis in in disease activity and resolution

  9. findings indicated that circulating memory Tfh cells, especially CCR7 (show CCR7 Proteins)+ICOS (show CTLA4 Proteins)+ memory Tfh cells, may be associated with the relapse of MS and may serve as a new therapeutic target

  10. Expression of mutant caspase-9 (show CASP9 Proteins) correlated with a downregulation of BAFFR (show TNFRSF13C Proteins) (B-cell-activating factor (show TNFSF13B Proteins) belonging to the TNF (show TNF Proteins) family (BAFF) receptor (show TNFRSF13C Proteins)) in B cells and ICOS (inducible T-cell costimulator) in T cells.

ICOS Protein Profile

Protein Summary

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

Gene names and symbols associated with ICOS

  • inducible T-cell costimulator (ICOS)
  • inducible T-cell costimulator (LOC100232284)
  • inducible T cell co-stimulator (Icos)
  • inducible T-cell co-stimulator (Icos)
  • inducible T-cell costimulator (Icos)
  • Ailim protein
  • CCLP protein
  • CD278 protein
  • CRP-1 protein
  • CVID1 protein
  • H4 protein
  • ICOS protein
  • Ly115 protein

Protein level used designations for ICOS

inducible T-cell costimulator , inducible T-cell co-stimulator , CD28 and CTLA-4-like protein , CD28-related protein 1 , activation-inducible lymphocyte immunomediatory molecule , inducible costimulator

705788 Macaca mulatta
747295 Pan troglodytes
100232284 Taeniopygia guttata
54167 Mus musculus
29851 Homo sapiens
64545 Rattus norvegicus
507026 Bos taurus
403456 Canis lupus familiaris
100715533 Cavia porcellus
733597 Sus scrofa
424105 Gallus gallus
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