anti-Inositol-Trisphosphate 3-Kinase B (ITPKB) Antibodies

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. Additionally we are shipping ITPKB Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ITPKB 320404  
ITPKB 3707 P27987
ITPKB 54260 P42335
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Top anti-ITPKB Antibodies at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of ITPKB expression in HeLa (A), SP2/0 (B), H9C2 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using ITPKB antibody. Immunohistochemistry of paraffin-embedded human liver injury using ITPKB antibody at dilution of 1:100 (x40 lens). 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using ITPKB antibody (ABIN5972108) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human liver injury using ITPKB antibody (ABIN5972108) at dilution of 1/100 (40x lens). 100 μL 11 to 16 Days
$426.40
Details
Human Mouse Un-conjugated ELISA, WB ITPKB monoclonal antibody (M01), clone 2F8 Western Blot analysis of ITPKB expression in Jurkat . Western Blot analysis of ITPKB expression in transfected 293T cell line by ITPKB monoclonal antibody (M01), clone 2F8.Lane 1: ITPKB transfected lysate(67.4 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6274219 staining Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. Western blot analysis of extracts from various samples, using IP3KB Antibody. Lane 1: 293 treated with blocking peptide; Lane 2: 293; Lane 3: hela; 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ITPKB using rabbit polyclonal ITPKB Antibody (R38) using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ITPKB gene. ITPKB Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated IHC, ELISA   100 μL 11 to 14 Days
$390.50
Details
Human Rabbit Un-conjugated WB   100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$375.83
Details
Human Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$522.50
Details

Top referenced anti-ITPKB Antibodies

  1. Human Monoclonal ITPKB Primary Antibody for ELISA, WB - ABIN561565 : Nalaskowski, Fliegert, Ernst, Brehm, Fanick, Windhorst, Lin, Giehler, Hein, Lin, Mayr: Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope. in The Journal of biological chemistry 2011 (PubMed)

  2. Human Polyclonal ITPKB Primary Antibody for IHC, IHC (p) - ABIN4327792 : Jin, Liu, Zhang, Huang, Jiang, Hou, Xu, Zhai, Gao, Wang, Wu, Zhu, Lu: The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer. in PLoS ONE 2015 (PubMed)

More Antibodies against ITPKB Interaction Partners

Mouse (Murine) Inositol-Trisphosphate 3-Kinase B (ITPKB) interaction partners

  1. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb restricts pre-T cell receptor induced metabolic activation to enforce coincidence-detection of pre-T cell receptor expression and Notch-engagement.

  2. These data identify Itpkb as an essential mediator of T cell activation and suggest Itpkb inhibition as a novel approach to treat autoimmune disease.

  3. Itpkb controls hematopoietic stem cell homeostasis and prevent death from severe anemia in mice.

  4. Itpkb controls survival, proliferation and cytokine production in mouse peripheral T cells.

  5. controls survival and prevents anergy in B cells

  6. Data present the structure of the complete catalytic domain of inositol 1,4,5-trisphophate 3-kinase B, including the CaM binding domain in complex with Mg(2+) and ATP.

  7. These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc]

  8. Itpkb and inositol tetrakisphosphate mediate a survival signal in B cells.

  9. InsP3KB is also a physiological modulator of myelopoiesis.

  10. B cells from Itpkb(-/-) Ig hen egg lysozyme mice possess an anergic phenotype, hypoproliferate in response to cognate Ag, and yet they exhibit enhanced Ag-induced calcium signaling

Human Inositol-Trisphosphate 3-Kinase B (ITPKB) interaction partners

  1. ITPKB does not affect the cellular actin structure and does not suppress dissemination of human lung cancer cells in mice.

  2. miR-140-5p regulates this context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (IP3k2). Therefore, the results of the present study demonstrated that miR-140-5p mediated drug-resistance in osteosarcoma cells by inducing autophagy.

  3. The authors confirm downregulation of miR-132 and upregulation of ITPKB in three distinct human Alzheimer's disease patient cohorts.

  4. ITPKB is increased in Alzheimer's brain three-fold in the cerebral cortex of most patients with Alzheimer's disease compared with control subjects and accumulates in dystrophic neurites associated with amyloid plaques.

  5. a specific increase in inositol 1,4,5-trisphosphate 3-kinase A and B (ITPKA and ITPKB) was observed upon hESCs spontaneous differentiation.

  6. IP3KB not only regulates cytoplasmic Ca(2+) signals by phosphorylation of subplasmalemmal and cytoplasmic Ins(1,4,5)P(3) but may also be involved in modulating nuclear Ca(2+) signals generated from these nuclear envelope invaginations.

  7. results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals

  8. We aim to summarize the existing information about functionally uncoupled IP(3)R and RyR channels, and to discuss the concept that those channels can participate in Ca(2+)-leak pathways.

  9. In each of the three isoforms a nuclear export signal has evolved in the catalytic domain either de novo (IP3K-A) or as a substitute for an earlier evolved corresponding N-terminal signal (IP3K-B and IP3K-C).

ITPKB Antigen Profile

Protein Summary

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.

Gene names and symbols associated with ITPKB

  • inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) antibody
  • inositol-trisphosphate 3-kinase B (ITPKB) antibody
  • inositol-trisphosphate 3-kinase B (itpkb) antibody
  • inositol-trisphosphate 3-kinase B (LOC698185) antibody
  • inositol-trisphosphate 3-kinase B (Itpkb) antibody
  • 1110033J02Rik antibody
  • E130307H12Rik antibody
  • IP3-3KB antibody
  • IP3K antibody
  • IP3K-B antibody
  • IP3KB antibody
  • PIG37 antibody
  • si:ch211-97m8.1 antibody

Protein level used designations for ITPKB

inositol-trisphosphate 3-kinase B , inositol 1,4,5-trisphosphate 3-kinase B , 1D-myo-inositol-trisphosphate 3-kinase B , inositol-trisphosphate 3-kinase B-like , IP3 3-kinase B , IP3K B , insP 3-kinase B , proliferation-inducing protein 37 , IP3K-B

GENE ID SPECIES
320404 Mus musculus
416743 Gallus gallus
457789 Pan troglodytes
490383 Canis lupus familiaris
540877 Bos taurus
563019 Danio rerio
698185 Macaca mulatta
100400613 Callithrix jacchus
100460190 Pongo abelii
100603824 Nomascus leucogenys
3707 Homo sapiens
54260 Rattus norvegicus
Selected quality suppliers for anti-ITPKB (ITPKB) Antibodies
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