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anti-Integral Membrane Protein 2B (ITM2B) Antibodies

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. Additionally we are shipping Integral Membrane Protein 2B Proteins (19) and Integral Membrane Protein 2B Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ITM2B 9445 Q9Y287
ITM2B 16432 O89051
ITM2B 290364 Q5XIE8
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Top anti-Integral Membrane Protein 2B Antibodies at antibodies-online.com

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: ITM2B Antibody [NBP1-88354] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY411840) Immunohistochemistry-Paraffin: ITM2B Antibody [NBP1-88354] - Staining of human duodenum shows strong cytoplasmic positivity with a granular pattern in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Mouse Un-conjugated FACS, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$522.50
Details
Cow Goat Un-conjugated IHC (p), ELISA, WB Anti-ITM2B antibody IHC staining of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ABIN962664 concentration 41396 ug/ml. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITM2B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ITM2B. Flow cytometric Analysis of Hela cells, using anti-ITM2B antibody (ABIN2454457), (Red), compared to a nonspecific negative control antibody, (Blue). 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: ITM2B Antibody [NBP2-17000] - Analysis of methanol-fixed HeLa, using antibody at 1:200 dilution. Western Blot: ITM2B Antibody [NBP2-17000] - 50 ug mouse brain lysate/extract 12% SDS-PAGE ITM2B antibody dilution: 1:1000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Goat Un-conjugated ELISA, WB Western Blot: ITM2B Antibody [NBP1-36963] - Analysis of ITM2B in Human Hippocampus lysate (35ug protein in RIPA buffer) using NBP1-36963 at 1 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Mouse Rabbit Un-conjugated IHC (p), WB ITM2B Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis in mouse cerebellum,lung tissue lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Cow Goat Un-conjugated WB   0.1 mg Log in to see 12 to 15 Days
$455.40
Details
Human Chicken Un-conjugated IHC (fro), WB Figure 1. Western Blot of various organs stained with anti BRI (ITM2B), N-terminal B6 mouse strain. 0.2 mg Log in to see 6 to 8 Days
$621.50
Details

ITM2B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-Integral Membrane Protein 2B Antibodies

  1. Human Polyclonal ITM2B Primary Antibody for ELISA, WB - ABIN451809 : Majewski, Lee, Jeong, Yoon, Kram, Kim, Tuziak, Bondaruk, Lee, Park, Tang, Chung, Shen, Ahmed, Johnston, Grossman, Dinney, Zhou, Harris, Snyder, Filipek, Narod, Watson, Lynch, Gazdar, Bar-Eli, Wu et al.: Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. ... in Laboratory investigation; a journal of technical methods and pathology 2008 (PubMed)

  2. Human Polyclonal ITM2B Primary Antibody for ICC, IF - ABIN4327783 : Baron, Baron, Baron: The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases. in Biochimica et biophysica acta 2015 (PubMed)

More Antibodies against Integral Membrane Protein 2B Interaction Partners

Human Integral Membrane Protein 2B (ITM2B) interaction partners

  1. ITM2B is expressed in most cortical neurons, neurons of the hippocampus and dentate nucleus, cerebellar Purkinje and granule cells, and (newly described here) in focal neurons in the basal ganglia, many neurons of the thalamus and brainstem, many cells in the ependyma and choroid plexus, and in the smooth muscle of blood vessels. ITM2B expression is prominent in plaques in AD-containing dystrophic neurites

  2. by modulating BRI2 processing using an ADAM10 (show ADAM10 Antibodies) inhibitor, a dual role for BRI2 in neurite outgrowth is suggested: phosphorylated full-length BRI2 appears to be important for the formation of neuritic processes, and BRI2 NTF (show RHBDL2 Antibodies) promotes neurite elongation.

  3. Familial British dementia (FBD) and familial Danish dementia (FDD) are caused by mutations in the BRI2 gene.

  4. when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident

  5. Data depict roles for Bri2 and apolipoprotein E4 (ApoE4) proteins in a long-term memory regulation pathway. A single mutation in one Itm2b/Bri2 allele can affect both long-term and working memory, while ApoE4 seems to regulate short-term/working memory.

  6. Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.

  7. Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 (show BCL6 Antibodies) protein (BCL6 (show BCL6 Antibodies)) repression in lymphoma.

  8. Data indicate that the mutation originates the highly amyloidogenic molecule integral membrane protein 2B ABri.

  9. This review support the hypothesis that BRI2 change during disease devel-opment, and thus may have a role in Alzheimer disease.

  10. It binds amyloid precursor protein (show APP Antibodies) to halt amyloid-b production and inhibits amyloid-b aggregation via its BRICHOS-domain suggesting a link between BRI2 and Alzheimer's disease (AD)

Mouse (Murine) Integral Membrane Protein 2B (ITM2B) interaction partners

  1. Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin (show SYP Antibodies) levels.

  2. BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE (show IDE Antibodies)).

  3. Suggest that Adam7 (show ADAM7 Antibodies) functions in fertilization through the formation of a complex with heat shock protein 5 (show HSPA5 Antibodies), calnexin (show CANX Antibodies) and Itm2b during capacitation in sperm.

  4. The shor form of ITM2B induces apoptosis in IL-2 (show IL2 Antibodies)-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2 (show BCL2 Antibodies), but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis.

  5. ITM2B(S) induces apoptosis via a caspase (show CASP3 Antibodies)-dependent mitochondrial pathway.

  6. BH3-only (show BBC3 Antibodies) protein ITM2Bs is able to induce apoptotic cell death in p53 (show TP53 Antibodies)+/+, as well as in p53 (show TP53 Antibodies)-/- cell lines.

  7. Itm2b mRNA was differentially expressed in mouse male reproductive tissues, during sexual maturation and up-regulated by testosterone.

Integral Membrane Protein 2B (ITM2B) Antigen Profile

Protein Summary

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Gene names and symbols associated with ITM2B

  • integral membrane protein 2B (ITM2B) antibody
  • integral membrane protein 2B (Itm2b) antibody
  • integral membrane protein 2Ba (itm2ba) antibody
  • integral membrane protein 2B L homeolog (itm2b.L) antibody
  • integral membrane protein 2B (itm2b) antibody
  • integral membrane protein 2b (itm2b) antibody
  • ABRI antibody
  • AI256040 antibody
  • Bri antibody
  • Bri2 antibody
  • Bricd2b antibody
  • D14Sel6 antibody
  • E3-16 antibody
  • E25B antibody
  • E25BMM antibody
  • FBD antibody
  • imBRI2 antibody
  • ITM2B antibody
  • MGC52745 antibody
  • MGC76131 antibody
  • wu:fc05f02 antibody
  • zgc:55770 antibody
  • zgc:85688 antibody

Protein level used designations for ITM2B

ABri/ADan amyloid peptide , BRICHOS domain containing 2B , immature BRI2 , transmembrane protein BRI , Integral membrane protein 2B (E25B protein) , integral membrane protein 2B , putative transmembrane protein E3-16 , transmembrane protein E3-16 , BRICHOS-like protein , integral membrane protein 2b

GENE ID SPECIES
9445 Homo sapiens
16432 Mus musculus
290364 Rattus norvegicus
323632 Danio rerio
380074 Xenopus laevis
394850 Xenopus (Silurana) tropicalis
395969 Gallus gallus
452714 Pan troglodytes
476916 Canis lupus familiaris
510575 Bos taurus
595120 Sus scrofa
100174988 Ovis aries
100528504 Ictalurus punctatus
100459693 Pongo abelii
100716017 Cavia porcellus
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