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Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. Additionally we are shipping Integral Membrane Protein 2B Proteins (19) and Integral Membrane Protein 2B Kits (1) and many more products for this protein.
Showing 10 out of 73 products:
Human Polyclonal ITM2B Primary Antibody for ICC, IF - ABIN4327783
Baron, Baron, Baron: The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases. in Biochimica et biophysica acta 2015
Human Polyclonal ITM2B Primary Antibody for ELISA, WB - ABIN451809
Majewski, Lee, Jeong, Yoon, Kram, Kim, Tuziak, Bondaruk, Lee, Park, Tang, Chung, Shen, Ahmed, Johnston, Grossman, Dinney, Zhou, Harris, Snyder, Filipek, Narod, Watson, Lynch, Gazdar, Bar-Eli, Wu et al.: Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. ... in Laboratory investigation; a journal of technical methods and pathology 2008
Bri2 BRICHOS domain is a potent inhibitor of IAPP (show IAPP Antibodies) fibril formation.Bri2 is highly expressed in human pancreatic islets and beta cells and colocalizes with IAPP (show IAPP Antibodies) both intracellularly and in islet amyloid deposits.
ITM2B is expressed in most cortical neurons, neurons of the hippocampus and dentate nucleus, cerebellar Purkinje and granule cells, and (newly described here) in focal neurons in the basal ganglia, many neurons of the thalamus and brainstem, many cells in the ependyma and choroid plexus, and in the smooth muscle of blood vessels. ITM2B expression is prominent in plaques in AD-containing dystrophic neurites
by modulating BRI2 processing using an ADAM10 (show ADAM10 Antibodies) inhibitor, a dual role for BRI2 in neurite outgrowth is suggested: phosphorylated full-length BRI2 appears to be important for the formation of neuritic processes, and BRI2 NTF (show RHBDL2 Antibodies) promotes neurite elongation.
Familial British dementia (FBD) and familial Danish dementia (FDD) are caused by mutations in the BRI2 gene.
when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident
Data depict roles for Bri2 and apolipoprotein E4 (ApoE4) proteins in a long-term memory regulation pathway. A single mutation in one Itm2b/Bri2 allele can affect both long-term and working memory, while ApoE4 seems to regulate short-term/working memory.
Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.
Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 (show BCL6 Antibodies) protein (BCL6 (show BCL6 Antibodies)) repression in lymphoma.
Data indicate that the mutation originates the highly amyloidogenic molecule integral membrane protein 2B ABri.
This review support the hypothesis that BRI2 change during disease devel-opment, and thus may have a role in Alzheimer disease.
Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin (show SYP Antibodies) levels.
BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE (show IDE Antibodies)).
Suggest that Adam7 (show ADAM7 Antibodies) functions in fertilization through the formation of a complex with heat shock protein 5 (show HSPA5 Antibodies), calnexin (show CANX Antibodies) and Itm2b during capacitation in sperm.
The shor form of ITM2B induces apoptosis in IL-2 (show IL2 Antibodies)-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2 (show BCL2 Antibodies), but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis.
ITM2B(S) induces apoptosis via a caspase (show CASP3 Antibodies)-dependent mitochondrial pathway.
BH3-only (show BBC3 Antibodies) protein ITM2Bs is able to induce apoptotic cell death in p53 (show TP53 Antibodies)+/+, as well as in p53 (show TP53 Antibodies)-/- cell lines.
Itm2b mRNA was differentially expressed in mouse male reproductive tissues, during sexual maturation and up-regulated by testosterone.
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
ABri/ADan amyloid peptide
, BRICHOS domain containing 2B
, immature BRI2
, transmembrane protein BRI
, Integral membrane protein 2B (E25B protein)
, integral membrane protein 2B
, putative transmembrane protein E3-16
, transmembrane protein E3-16
, BRICHOS-like protein
, integral membrane protein 2b
, integral membrane protein 2B, like