anti-Integral Membrane Protein 2B (ITM2B) Antibodies

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. Additionally we are shipping Integral Membrane Protein 2B Proteins (19) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ITM2B 9445 Q9Y287
ITM2B 16432 O89051
ITM2B 290364 Q5XIE8
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Top anti-Integral Membrane Protein 2B Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, FACS, IF, IHC, WB ABIN570955 (0.3µg/ml) staining of HepG2 cell lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. ABIN570955 Immunofluorescence analysis of paraformaldehyde fixed A431 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing Golgi apparatus and cytoplasmic staining. The nucl 100 μg 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
$515.63
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Cow Goat Un-conjugated ELISA, IHC, IHC (p), WB Anti-ITM2B antibody IHC staining of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962664 concentration 41396 ug/ml. Anti-ITM2B antibody IHC of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. 50 μg 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITM2B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ITM2B. Flow cytometric Analysis of Hela cells, using anti-ITM2B antibody (ABIN2454457), (Red), compared to a nonspecific negative control antibody, (Blue). 0.1 mL 2 to 3 Days
$482.90
Details
Mouse Rabbit Un-conjugated IHC (p), WB ITM2B Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis in mouse cerebellum,lung tissue lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Cow Goat Un-conjugated WB   0.1 mg 4 to 8 Days
$462.00
Details
Human Chicken Un-conjugated IHC (fro), WB Figure 1. Western Blot of various organs stained with anti BRI (ITM2B), N-terminal B6 mouse strain. 0.2 mg 6 to 8 Days
$621.50
Details
Human Goat Un-conjugated IHC (p), ELISA, WB 50 μg 12 to 14 Days
$686.14
Details
Human Goat Un-conjugated ELISA, WB ITM2B polyclonal antibody  (1 ug/mL) staining of human hippocampus lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 11 to 12 Days
$374.67
Details

Top referenced anti-Integral Membrane Protein 2B Antibodies

  1. Human Polyclonal ITM2B Primary Antibody for ELISA, WB - ABIN451809 : Majewski, Lee, Jeong, Yoon, Kram, Kim, Tuziak, Bondaruk, Lee, Park, Tang, Chung, Shen, Ahmed, Johnston, Grossman, Dinney, Zhou, Harris, Snyder, Filipek, Narod, Watson, Lynch, Gazdar, Bar-Eli, Wu et al.: Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. ... in Laboratory investigation; a journal of technical methods and pathology 2008 (PubMed)

  2. Human Polyclonal ITM2B Primary Antibody for ICC, IF - ABIN4327783 : Baron, Baron, Baron: The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases. in Biochimica et biophysica acta 2015 (PubMed)

More Antibodies against Integral Membrane Protein 2B Interaction Partners

Human Integral Membrane Protein 2B (ITM2B) interaction partners

  1. Analysis of knock-in mice harboring the disease mutation revealed the memory defect in the mice, attributable to loss of protective function of BRI2. (REVIEW)

  2. We found a novel possible pathogenic variant in the ITM2B gene in one amyotrophic lateral sclerosis patient with a complex phenotype, associating movement disorders, psychiatric and cognitive features, deafness, and optic atrophy.

  3. Bri2 BRICHOS monomers potently prevent neuronal network toxicity of amyloid-beta peptide (A-beta), while dimers strongly suppress A-beta fibril formation.

  4. Bri2 BRICHOS domain is a potent inhibitor of IAPP fibril formation.Bri2 is highly expressed in human pancreatic islets and beta cells and colocalizes with IAPP both intracellularly and in islet amyloid deposits.

  5. ITM2B is expressed in most cortical neurons, neurons of the hippocampus and dentate nucleus, cerebellar Purkinje and granule cells, and (newly described here) in focal neurons in the basal ganglia, many neurons of the thalamus and brainstem, many cells in the ependyma and choroid plexus, and in the smooth muscle of blood vessels. ITM2B expression is prominent in plaques in AD-containing dystrophic neurites

  6. by modulating BRI2 processing using an ADAM10 inhibitor, a dual role for BRI2 in neurite outgrowth is suggested: phosphorylated full-length BRI2 appears to be important for the formation of neuritic processes, and BRI2 NTF promotes neurite elongation.

  7. Familial British dementia (FBD) and familial Danish dementia (FDD) are caused by mutations in the BRI2 gene.

  8. when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident

  9. familial Danish dementia mutation and pE posttranslational modification are primary elements driving intact ADan into an amyloidogenic/neurotoxic pathway while truncations at the C-terminus eliminate the pro-amyloidogenic characteristics of the molecule

  10. Data depict roles for Bri2 and apolipoprotein E4 (ApoE4) proteins in a long-term memory regulation pathway. A single mutation in one Itm2b/Bri2 allele can affect both long-term and working memory, while ApoE4 seems to regulate short-term/working memory.

  11. Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.

  12. Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 protein (BCL6) repression in lymphoma.

  13. Data indicate that the mutation originates the highly amyloidogenic molecule integral membrane protein 2B ABri.

  14. This review support the hypothesis that BRI2 change during disease devel-opment, and thus may have a role in Alzheimer disease.

  15. It binds amyloid precursor protein to halt amyloid-b production and inhibits amyloid-b aggregation via its BRICHOS-domain suggesting a link between BRI2 and Alzheimer's disease (AD)

  16. Findings highlight pathogenic mechanism(s) associated with ITM2B mutations underlying dementia or retinal disease and add a new candidate to the list of genes involved in inherited retinal dystrophies.

  17. Structural modeling of transmembrane (BRICHOS) domains of BRI2/ITM2B and SFTPC (pulmonary surfactant protein C) precursor identifies conserved region structurally complementary to beta-sheet/amyloid-prone region in BRICHOS domain-containing proteins.

  18. These results suggest that BRI2 may prevent access of BACE1 to APP and the BRI2/BACE1 interaction may mediate the reduction in BACE1 levels.

  19. Similarities of ABri and ADan to Abeta in Alzheimer's disease suggest that posttranslational pGlu-modification of amyloid peptides might represent general pathological mechanism leading to increased aggregation and toxicity forms of degenerative dementias.

  20. Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin levels.

Mouse (Murine) Integral Membrane Protein 2B (ITM2B) interaction partners

  1. Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin levels.

  2. BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).

  3. Suggest that Adam7 functions in fertilization through the formation of a complex with heat shock protein 5, calnexin and Itm2b during capacitation in sperm.

  4. The shor form of ITM2B induces apoptosis in IL-2-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2, but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis.

  5. ITM2B(S) induces apoptosis via a caspase-dependent mitochondrial pathway.

  6. BH3-only protein ITM2Bs is able to induce apoptotic cell death in p53+/+, as well as in p53-/- cell lines.

  7. Itm2b mRNA was differentially expressed in mouse male reproductive tissues, during sexual maturation and up-regulated by testosterone.

Integral Membrane Protein 2B (ITM2B) Antigen Profile

Protein Summary

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Gene names and symbols associated with ITM2B

  • integral membrane protein 2B (ITM2B) antibody
  • integral membrane protein 2B (Itm2b) antibody
  • integral membrane protein 2Ba (itm2ba) antibody
  • integral membrane protein 2B L homeolog (itm2b.L) antibody
  • integral membrane protein 2B (itm2b) antibody
  • integral membrane protein 2b (itm2b) antibody
  • integral membrane protein 2Bb (itm2bb) antibody
  • ABRI antibody
  • AI256040 antibody
  • Bri antibody
  • Bri2 antibody
  • Bricd2b antibody
  • D14Sel6 antibody
  • E3-16 antibody
  • E25B antibody
  • E25BMM antibody
  • FBD antibody
  • imBRI2 antibody
  • ITM2B antibody
  • itm2bl antibody
  • MGC52745 antibody
  • MGC76131 antibody
  • wu:fb94b03 antibody
  • wu:fc05f02 antibody
  • zgc:55770 antibody
  • zgc:64142 antibody
  • zgc:85688 antibody

Protein level used designations for ITM2B

ABri/ADan amyloid peptide , BRICHOS domain containing 2B , immature BRI2 , transmembrane protein BRI , Integral membrane protein 2B (E25B protein) , integral membrane protein 2B , putative transmembrane protein E3-16 , transmembrane protein E3-16 , BRICHOS-like protein , integral membrane protein 2b , fb94b03 , integral membrane protein 2B, like

GENE ID SPECIES
9445 Homo sapiens
16432 Mus musculus
290364 Rattus norvegicus
323632 Danio rerio
380074 Xenopus laevis
394850 Xenopus (Silurana) tropicalis
395969 Gallus gallus
452714 Pan troglodytes
476916 Canis lupus familiaris
510575 Bos taurus
595120 Sus scrofa
100174988 Ovis aries
100528504 Ictalurus punctatus
100459693 Pongo abelii
100716017 Cavia porcellus
406248 Danio rerio
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