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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Antibodies (164) and IL27 Proteins (22) and many more products for this protein.
Showing 10 out of 53 products:
Mouse (Murine) IL27 ELISA Kit for Sandwich ELISA - ABIN365240
Le Texier, Thebault, Carvalho-Gaspar, Vignard, Merieau, Usal, Cuturi, Wood, Chiffoleau: Immunoregulatory function of IL-27 and TGF-?1 in cardiac allograft transplantation. in Transplantation 2012
Human IL27 ELISA Kit for Sandwich ELISA - ABIN414441
Li, Zhang, Ge, Zhou, Qi, Ma, Xue, Zhou, Yang: Elevated interleukin-27 enhances the polarization of Th1/Tc1 cells and the production of proinflammatory cytokines in primary immune thrombocytopenia. in Human immunology 2012
Rat (Rattus) IL27 ELISA Kit for Sandwich ELISA - ABIN416127
Gao, Pang, Zhang, Li, Tu, Zhang, Niu, Xiong, Xiao, Zhao, Gao, Wang: Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata. in Frontiers in pharmacology 2016
this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1 (show IL27RA ELISA Kits)) on fetal membranes in cases of preterm birth
results indicate that elevated IL-27 strongly correlates with EOS (show IKZF4 ELISA Kits) and may provide additional diagnostic value along with PCT (show UROD ELISA Kits).
serum interleukin-27 and interleukin-35 concentrations in patients with Guillain-Barre syndrome
Expression of IL-27 in the serum was markedly increased in patients with sepsis-induced myocardial dysfunction compared with that in controls.
IL-27 significantly inhibited the M2 macrophages polarization and dampened the proliferation, migration and metastasis of pancreatic cancer cells and as well enhanced the efficacy of gemcitabine.
IL-27 increased NLRP3 (show NLRP3 ELISA Kits) inflammasome activation in monocytes with enhanced release of IL-1 beta (show IL1B ELISA Kits).
this study shows that interleukin 27 is up-regulated in patients with active inflammatory bowel disease
IL-27 polymorphisms might play a protective role for the development of ulcerative colitis in the Mexican population
Nrf2 (show GABPA ELISA Kits) Induces IL-17D (show IL17D ELISA Kits) to mediate tumor and virus surveillance.
IL-27 stimulation activated STAT1 (show STAT1 ELISA Kits) and STAT3 (show STAT3 ELISA Kits) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (show STAT1 ELISA Kits)/3 pathway, which then leads to the upregulation of IL-6 (show IL6 ELISA Kits), IP-10 (show CXCL10 ELISA Kits), and MIG (show CXCL9 ELISA Kits)
TTP (show ZFP36 ELISA Kits), encoded by Zfp36 (show ZFP36 ELISA Kits), degrades p28 (show GSTO1 ELISA Kits) to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.
these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1-like cells in celiac disease
endogenous levels of IL-27 affected the oncogenic properties of mutant p53 (show TP53 ELISA Kits) in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.
Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin (show LTF ELISA Kits).
Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS injection compared with control specimens.
these findings highlight critical roles for IFN-gamma (show IFNG ELISA Kits) and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation
IL-27-induced Sca-1 (show Ly6a ELISA Kits)(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (show EOMES ELISA Kits) and Blimp1 (show PRDM1 ELISA Kits).
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (show IL6 ELISA Kits) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interluekin 27
, interleukin 27
, interleukin 27 p28 subunit