anti-Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4) Antibodies

LILRB4 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. Additionally we are shipping and LILRB4 Kits (21) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LILRB4 11006 Q8NHJ6
LILRB4 14728 Q64281
LILRB4    
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Top anti-LILRB4 Antibodies at antibodies-online.com

Showing 10 out of 66 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of A549 cells, using LILRB4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CD85K / LILRB4 Antibody (N-term) in MDA-MB435 cell line lysates (35ug/lane). This demonstrates the LILRB4 antibody detected the LILRB4 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure . Western Blot; Sample: Rat Adrenal Gland Tissue. 100 μg 13 to 16 Days
$342.00
Details
Human Rabbit Un-conjugated WB Western blot analysis in MDA-MB435 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, IF   100 μL Available
$363.46
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using LILRB4 antibody. 200 μL 12 to 14 Days
$438.90
Details
Human Mouse Un-conjugated FACS   100 μg 11 to 14 Days
$595.83
Details
Human Mouse CF FACS   100 Tests 11 to 14 Days
$793.83
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using LILRB4 antibody. 100 μL 11 to 13 Days
$366.77
Details
Mouse Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$390.50
Details

Top referenced anti-LILRB4 Antibodies

  1. Human Monoclonal LILRB4 Primary Antibody for FACS - ABIN4895889 : Zimmer, Luce, Gaignier, Nony, Naveau, Biola-Vidamment, Pallardy, Van Overtvelt, Mascarell, Moingeon: Identification of a new phenotype of tolerogenic human dendritic cells induced by fungal proteases from Aspergillus oryzae. in Journal of immunology (Baltimore, Md. : 1950) 2011 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal LILRB4 Primary Antibody for FACS, WB - ABIN4899298 : Waschbisch, Sanderson, Krumbholz, Vlad, Theil, Schwab, Mäurer, Derfuss: Interferon beta and vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients. in PLoS ONE 2015 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal LILRB4 Primary Antibody for FACS - ABIN4895887 : Ulges, Klein, Reuter, Gerlitzki, Hoffmann, Grebe, Staudt, Stergiou, Bohn, Brühl, Muth, Yurugi, Rajalingam, Bellinghausen, Tuettenberg, Hahn, Reißig, Haben, Zipp, Waisman, Probst, Beilhack, Buchou et al.: Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. ... in Nature immunology 2015 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal LILRB4 Primary Antibody for CyTOF, FACS - ABIN4899300 : Gleissner, Zastrow, Klingenberg, Kluger, Konstandin, Celik, Haemmerling, Shankar, Giese, Katus, Dengler: IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells. in European journal of immunology 2006 (PubMed)

More Antibodies against LILRB4 Interaction Partners

Human Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4) interaction partners

  1. LILRB4 expression is decreased in hypertrophic hearts.

  2. Our data demonstrate that anti-LILRB4 CAR-T cells specifically target monocytic acute myeloid leukemia cells with no toxicity to normal hematopoietic progenitors.

  3. LILRB4 orchestrates tumour invasion pathways in monocytic leukaemia cells by creating an immunosuppressive microenvironment; LILRB4 represents a compelling target for the treatment of monocytic AML

  4. Results suggest that ILT3 played an important role in tumor progression in colorectal cancer by possible influence on CD45RO+ T cells in the tumor microenvironment.

  5. These results suggest that tyrosine phosphorylation may be critical in FcgammaRI-dependent endocytosis/phagocytosis that may be regulated by LILRB4 by triggering dephosphorylation of key signalling proteins.

  6. ILT3 may functionally contribute to a regulatory network controlling tumor progression by suppressing the Akt pathway.

  7. The ILT3 PBs/PCs were suggested to be developmentally equivalent based on the simultaneous generation of these populations upon activation of memory B cells in vitro ILT3 expression was found to be induced efficiently by IL-2, while IFN-alpha effectively induced ILT3 PBs/PCs in vitro Utilizing the elevated ILT3 will support opening a new avenue for molecular markers for, pathogenic cells.

  8. this study shows that LILRB4 might have dual inhibitory and activating functions, depending on the position of the functional tyrosine residues in its immunoreceptor tyrosine-based inhibitory motifs and/or the nature of the stimuli

  9. LILRB4 expression is significantly upregulated in human masticatory mucosa during wound healing

  10. Identification of ILT4 as a cellular receptor for CSP C4d

  11. involvement of ILT3 and ILT4 in the modulation of immune responsiveness in multiple sclerosis by both interferon and vitamin D

  12. Cyclosporine up-regulated the expression of ILT3 and ILT4 on natural killer cells, which influenced their cytotoxicity against tumor cells.

  13. ILT3Fc inhibits T cell activation and induces the generation of suppressor T cells targeting multiple inflammatory miRNA pathways.

  14. Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.

  15. upregulated on antigen-presenting cells in response to Salmonella infection

  16. Data show that LILRB4 is a potent inhibitor of monocyte activation via FcgammaRI.

  17. report that ILT2 receptor, ILT3 receptor, ILT4 receptor, and KIR2DL4 receptor expression is up-regulated by HLA-G histocompatibility antigen in antigen-presenting cells, natural killer cells, and T cells

  18. ILT3 precursor RNA is expressed and retained in nuclei of resting endothelial cells.

  19. Our findings indicate that expression of ILT3 and ILT4 on CLL B cells represents a phenotypic abnormality that may play a role in tolerization of tumor-specific T cells.

  20. The inhibitory effect of serum and membrane ILT3 in a humanized SCID mouse model describes an immune-escape mechanism that could contribute to impaired T cell responses in patients with cancer.

Mouse (Murine) Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4) interaction partners

  1. LILRB4 knockout accelerates cardiac hypertrophy induced by aortic banding in mice. LILRB4 deficiency promotes inflammation and apoptosis in aortic banding-stimulated heart injury.

  2. Targeting hepatic LILRB4 to improve its expression or activation represents a promising strategy for the treatment of non alcoholic fatty liver diseases as well as related liver and metabolic diseases

  3. Results suggest that plasma cell development from memory and marginal zone B cells, as well as subsequent antibody production, are suppressed via glycoprotein 49B (gp49B).

  4. LILRB4 can downregulate the development of pathologic allergic inflammation.

  5. receptor attenuates the number of these mature DCs and attendant IL-4-producing lymphocytes in the lymph nodes, and accordingly, the ability of DCs to elicit pathologic Th2 pulmonary inflammation

  6. Inhibition of anaphylactic inflammation by the gp49B1 receptor on mast cells.

  7. Gp49B1 is a unique inhibitory receptor that is induced in multiple lineages of innate and adaptive immune cells during an infection and controls their IFN-gamma, but not cytotoxic responses.

  8. Expression of gp49B was detected on peripheral eosinophils of control mice and on eosinophils from lungs of mice treated with RW, suggesting a role for gp49B on eosinophils in dampening allergic inflammatory responses.

  9. study reports that gp49B, is expressed on dendritic cells and downregulates cellular activity to prevent the excessive activation of T cells in vitro and in vivo

LILRB4 Antigen Profile

Protein Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with LILRB4

  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 (LILRB4) antibody
  • leukocyte immunoglobulin like receptor B4 (LILRB4) antibody
  • leukocyte immunoglobulin-like receptor, subfamily B, member 4A (Lilrb4a) antibody
  • CD85K antibody
  • gp49 antibody
  • Gp49b antibody
  • HM18 antibody
  • ILT-3 antibody
  • ILT3 antibody
  • LIR-5 antibody
  • LIR5 antibody

Protein level used designations for LILRB4

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 , CD85 antigen-like family member K , immunoglobulin-like transcript 3 , leukocyte immunoglobulin-like receptor 5 , leukocyte immunoglobulin-like receptor subfamily B member 4 , monocyte inhibitory receptor HM18 , glycoprotein 49 B , mast cell surface glycoprotein Gp49B

GENE ID SPECIES
100587262 Nomascus leucogenys
11006 Homo sapiens
14728 Mus musculus
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