LILRB4 antibody (AA 22-259)

Catalog No. ABIN6143221

Product Details anti-LILRB4 Antibody

Target: LILRB4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))

Binding Specificity: AA 22-259

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LILRB4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: QAGPLPKPTL WAEPGSVISW GNSVTIWCQG TLEAREYRLD KEESPAPWDR QNPLEPKNKA RFSIPSMTED YAGRYRCYYR SPVGWSQPSD PLELVMTGAY SKPTLSALPS PLVTSGKSVT LLCQSRSPMD TFLLIKERAA HPLLHLRSEH GAQQHQAEFP MSPVTSVHGG TYRCFSSHGF SHYLLSHPSD PLELIVSGSL EGPRPSPTRS VSTAAGPEDQ PLMPTGSVPH SGLRRHWE

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4 (NP_001265355.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LILRB4

Target: LILRB4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))

Alternative Name: LILRB4 (LILRB4 Products)

Synonyms: CD85K antibody, ILT-3 antibody, ILT3 antibody, LIR-5 antibody, LIR5 antibody, Gp49b antibody, HM18 antibody, gp49 antibody, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 antibody, leukocyte immunoglobulin like receptor B4 antibody, leukocyte immunoglobulin-like receptor, subfamily B, member 4A antibody, LILRB4 antibody, Lilrb4a antibody

Background: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.,LILRB4,CD85K,ILT-3,ILT3,LIR-5,LIR5,Epigenetics & Nuclear Signaling,Immunology & Inflammation,CD markers,Cardiovascular,Blood,Blood Cell Antigens,LILRB4

Molecular Weight: 49 kDa

Gene ID: 11006

UniProt: Q8NHJ6