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Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Additionally we are shipping Lysine (K)-Specific Demethylase 4D Proteins (6) and many more products for this protein.
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Human Polyclonal KDM4D Primary Antibody for WB - ABIN2774949
Katoh, Katoh: Identification and characterization of JMJD2 family genes in silico. in International journal of oncology 2004
Show all 3 Pubmed References
Human Polyclonal KDM4D Primary Antibody for ChIP, WB - ABIN315882
Luo, Chang, Zhong, Pandey, Semenza: Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. in Proceedings of the National Academy of Sciences of the United States of America 2012
A high nuclear expression of KDM4D in samples of pancreatic resection margins significantly and independently predicted an earlier recurrence and could thus be used in the assessment of risk of relapse in clinical practice.
The results demonstrate a novel mechanism by which Kdm4d regulates DNA replication by reducing the H3K9me3 level to facilitate formation of preinitiation complex.
KDM4B (show KDM4B Antibodies) and KDM4D expression may associate with an aggressive subtype of classical Hodgkin lymphoma and be linked with radioresistance
KDM4D-RNA interaction is required for KDM4D accumulation at DNA breakage sites
PARP1 (show PARP1 Antibodies)-dependent recruitment of KDM4D histone demethylase (show MBD2 Antibodies) to DNA damage sites promotes double-strand break repair.
The molecular basis for JMJD2 (show KDM4A Antibodies) site specificity revealed by X-ray crystallography.
Results demonstrate that JMJD2D can stimulate cell proliferation and survival, suggesting that its inhibition may be helpful in the fight against cancer
identified two related histone demethylases, JMJD2A (show KDM4A Antibodies) and JMJD2D
These results suggest that demethylation of H3K9 in round spermatids is dispensable for spermatogenesis but that possible defects in Kdm4d-null elongating spermatids could be rescued by functional redundancy of the KDM4B (show KDM4B Antibodies) demethylase (show MBD2 Antibodies).
Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys- 9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).
jmjC domain-containing histone demethylation protein 3D
, jumonji domain containing 2D
, jumonji domain-containing protein 2D
, lysine-specific demethylase 4D
, lysine (K)-specific demethylase 4D
, lysine-specific demethylase 4D-like