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The oncogenic protein encoded by MCF2 is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Additionally we are shipping MCF2 Proteins (3) and many more products for this protein.
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Results support a role for Dbl oncogene in mammary epithelial cell differentiation and transformation and suggest the relevance of GEF deregulation in tumor onset and progression.
Phosphoinositide 3-kinase C2beta regulates RhoA and the actin cytoskeleton through an interaction with Dbl
Dbl is regulated by hamartin through association with ezrin.
proto-oncogene dbl is not a major target for sporadic testicular germ cell tumors
data describe 4 splicing variants of the human DBL (MCF-2) proto-oncogene that show different tissue distributions and guanine nucleotide exchange factor specificities
provides fundamental data on the structure of Mcf-2, which regulates a variety of cellular signaling pathways
These data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 by Dbl is dependent on functional ERM proteins and is important for directional cell migration.
Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain
Nm23-H1 can negatively regulate cell migration and tumor metastasis by modulating the activity of Cdc42 and possibly other Rho family members through interaction with Dbl-1
The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.
Oncogene MCF2 (oncogene DBL)
, proto-oncogene DBL
, proto-oncogene MCF-2