anti-MLX Interacting Protein (MLXIP) Antibodies

MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000. Additionally we are shipping MLX Interacting Protein Kits (4) and MLX Interacting Protein Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MLXIP 22877 Q9HAP2
MLXIP 208104 Q2VPU4
MLXIP 304479  
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Top anti-MLX Interacting Protein Antibodies at antibodies-online.com

Showing 10 out of 36 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated IHC, WB WB Suggested Anti-MLXIP Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  PANC1 cell lysate MLXIP is supported by BioGPS gene expression data to be expressed in PANC1 Host:  Rabbit  Target Name:  MLXIP  Sample Type:  Human Fetal Heart  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Rabbit Anti-MLXIP Antibody  Catalog Number: ARP35892_P050 Formalin Fixed Paraffin Embedded Tissue: Human Adult heart  Observed Staining: Cytoplasmic (stronger than ARP35891) Primary Antibody Concentration: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 – 2.0 sec Protocol located in Reviews and Data. WB Suggested Anti-MLXIP Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Jurkat cell lysate MLXIP is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle reacted with MLXIP Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of MLXIP Antibody (N-term) in mouse lung tissue lysates (35ug/lane). This demonstrates the MLXIP antibody detected the MLXIP protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC (p), WB MLXIP antibody (N-term) (ABIN654186) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of K-562 cells, using MLXIP antibody. ABIN6273140 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 200 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$360.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged MLXIP is 0.03 ng/ml as a capture antibody. Western Blot detection against Immunogen (36.41 KDa) . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human skeletal muscle with MLXIP polyclonal antibody  shows strong cytoplasmic positivity at 1:50-1:200 dilution. 100 μL Log in to see 11 to 12 Days
$577.33
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL Log in to see 11 to 16 Days
$658.43
Details

Top referenced anti-MLX Interacting Protein Antibodies

  1. Dog (Canine) Polyclonal MLXIP Primary Antibody for IHC, WB - ABIN2776519 : Stoltzman, Peterson, Breen, Muoio, Billin, Ayer: Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

More Antibodies against MLX Interacting Protein Interaction Partners

Human MLX Interacting Protein (MLXIP) interaction partners

  1. Data (including data from studies in knockout mice) suggest that MONDOA shuttles to nucleus of pancreatic beta-cells where it is required for induction of glucose-responsive genes arrestin domain-containing protein 4 (ARRDC4) and thioredoxin interacting protein (TXNIP).

  2. MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin signaling

  3. Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism.

  4. These results suggest that C771G polymorphism of MLXIPL gene is associated with coronary stenosis and its severity.

  5. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in apoptosis

  6. regulatory relationship between mTOR and the MondoA-TXNIP axis that we propose contributes to glucose homeostasis

  7. Suppression of Txnip by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei.

  8. An important contribution of MondoA to leukemia aggressiveness, which makes MondoA a potential candidate for targeted treatment of acute lymphoblastic leukemia.

  9. the MondoA-TXNIP regulatory circuit has a role in the hexose transport curb, although other redundant pathways also contribute

  10. Induction of TXNIP under lactic acidosis is caused by the activation of the glucose-sensing helix-loop-helix transcriptional complex MondoA:Mlx, which is usually triggered upon glucose exposure.

  11. Glucose is required at two additional steps to stimulate the transcription activation function of MondoA-Mlx complexes.

  12. Data show that for both MondoA and Mlx, the C-terminal domain CRM-1 has cytoplasmic localization activity that is required by the protein monomers to accumulate in the cytoplasm.

  13. Endogenous MondoA and Mlx associate with mitochondria in primary skeletal muscle.

  14. These studies suggest a key role for MondoA:Mlx complexes in the adaptive transcriptional response to changes in extracellular glucose concentration and peripheral glucose uptake.

  15. Data suggest that glutamine-dependent mitochondrial anapleurosis dictates glucose uptake and aerobic glycolysis by blocking MondoA:Mlx-dependent transcriptional activation of TXNIP.

Mouse (Murine) MLX Interacting Protein (MLXIP) interaction partners

  1. Data (including data from studies in knockout mice) suggest that MondoA shuttles to nucleus of pancreatic beta-cells where it is required for induction of glucose-responsive genes arrestin domain-containing protein 4 (Arrdc4) and thioredoxin interacting protein (Txnip).

  2. MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin signaling

  3. Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism.

  4. MondoA is a basic helix-loop-helix/leucine zipper transcription factor that is expressed predominantly in skeletal muscle. Mice deficient for MondoA excel in sprinting, as their skeletal muscles display an enhanced glycolytic capacity.

  5. MondoA-Mlx complexes sense elevated levels of G6P and adenine nucleotides to trigger a TXNIP-dependent feedback inhibition of glycolysis

  6. Suppression of Txnip by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei.

  7. the MondoA-TXNIP regulatory circuit has a role in the hexose transport curb, although other redundant pathways also contribute

  8. Induction of TXNIP under lactic acidosis is caused by the activation of the glucose-sensing helix-loop-helix transcriptional complex MondoA:Mlx, which is usually triggered upon glucose exposure.

MLX Interacting Protein (MLXIP) Antigen Profile

Protein Summary

MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000

Gene names and symbols associated with MLXIP

  • MLX interacting protein (MLXIP) antibody
  • MLX interacting protein L homeolog (mlxip.L) antibody
  • MLX interacting protein (mlxip) antibody
  • MLX interacting protein (Mlxip) antibody
  • AW228700 antibody
  • B930074I24 antibody
  • bHLHe36 antibody
  • MGC83884 antibody
  • Mir antibody
  • mKIAA0867 antibody
  • MONDOA antibody
  • RGD1560774 antibody
  • si:ch211-110p13.4 antibody

Protein level used designations for MLXIP

MLX interacting protein , MondoA-like , MLX-interacting protein-like , MLX-interacting protein , Mlx interactor , MondoA , class E basic helix-loop-helix protein 36 , transcriptional activator MondoA

GENE ID SPECIES
416857 Gallus gallus
431799 Xenopus laevis
452323 Pan troglodytes
705874 Macaca mulatta
783217 Bos taurus
798052 Danio rerio
100021969 Monodelphis domestica
100036655 Xenopus (Silurana) tropicalis
100060001 Equus caballus
100156510 Sus scrofa
100344781 Oryctolagus cuniculus
100439640 Pongo abelii
100558305 Anolis carolinensis
22877 Homo sapiens
208104 Mus musculus
304479 Rattus norvegicus
477464 Canis lupus familiaris
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