MLXIP antibody (N-Term)

Catalog No. ABIN6992189

The Rabbit Polyclonal anti-MLXIP antibody is suitable to detect MLXIP in samples from Human. It has been validated for ELISA and WB.

Quick Overview for MLXIP antibody (N-Term) (ABIN6992189)

Target: MLXIP (MLX Interacting Protein (MLXIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLXIP antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-MLXIP Antibody

Binding Specificity: N-Term

Purification: MLXIP Antibody is affinity chromatography purified via peptide column.

Immunogen: MLXIP antibody was raised against a peptide corresponding to 19 amino acids near the amino terminus of human MLXIP.

Isotype: IgG

Application Details

Application Notes: MLXIP antibody can be used for Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: MLXIP Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: MLXIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for MLXIP

Target: MLXIP (MLX Interacting Protein (MLXIP))

Alternative Name: MLXIP

Background: MLXIP Antibody: MLXIP is a member of the Myc superfamily of transcription factors and functions as part of a heterodimer with Max-like protein X (MLX) to activate transcription (1). MLXIP contributes to the regulation of glucose homeostasis as the MLXIP/MLX heterodimer activates expression of thioredoxin-interacting protein (TXNIP), a potent inhibitor of cellular glucose uptake and aerobic glycolysis. The mammalian target of rapamycin (mTOR) suppresses the activation of the TXNIP pathway by binding to MLXIP, thereby preventing the MLXIP/MLX heterodimer formation (2). MLXIP interaction with Myc may also be involved in metabolic reprogramming and tumorigenesis (3).

Molecular Weight: Predicted: 20 kDa

Observed: 21 kDa

Gene ID: 22877

NCBI Accession: NP_055753

UniProt: Q9HAP2