N-Myc Downstream Regulated 1 Proteins (NDRG1)

NDRG1 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. Additionally we are shipping N-Myc Downstream Regulated 1 Antibodies (198) and N-Myc Downstream Regulated 1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NDRG1 10397 Q92597
NDRG1 17988 Q62433
Rat NDRG1 NDRG1 299923 Q6JE36
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Top N-Myc Downstream Regulated 1 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 14 to 16 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 12 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days

NDRG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for N-Myc Downstream Regulated 1 (NDRG1) Interaction Partners

Human N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. These findings indicate that NDRG1 expression is associated with both prognosis and c-Myc (show MYC Proteins) expression in lung adenocarcinoma

  2. Meta-analysis showed that low NDRG1 expression was significantly associated with worse survival in colorectal cancer and pancreatic cancer but higher survival of patients with liver cancer and gallbladder cancer. No significant association was observed between low NDRG1 expression and survival in gastric cancer or esophageal cancer.

  3. Findings indicate a positive feedback loop between cancer associated fibroblast (CAFs (show TBX1 Proteins)) and box Q1 (FOXQ1 (show FOXQ1 Proteins))/N-myc downstream-regulated gene 1 (NDRG1) axis in neoplastic cells to drive hepatocellular carcinoma (HCC (show FAM126A Proteins)) initiation, suggesting new potential therapeutic targets for HCC (show FAM126A Proteins).

  4. In summary, CAPE attenuates Nasopharyngeal carcinoma (NPC (show NPC1 Proteins))cell proliferation and invasion by upregulating NDRG1 expression via MAPK (show MAPK1 Proteins) pathway and by inhibiting phosphorylation of STAT3 (show STAT3 Proteins). Considering the poor prognosis of NPC (show NPC1 Proteins) patients with metastasis, CAPE could be a promising agent against NPC (show NPC1 Proteins).

  5. These results indicate the N-terminus region and phosphorylation at Ser330 could be crucial for NDRG1 nuclear localization and function. PTEN silencing indicated that p-NDRG1 (Thr346) could be regulated differentially in different tumor cell-types, indicating PTEN may be involved in the mechanism(s) underlying the pleiotropic activity of NDRG1.

  6. present study shows that HER4 and/or NDRG1 might play a critical role for the cell survival and chemo-resistance of Osteosarcoma (OS), and could be used as potential therapeutic targets in OS.

  7. our study described two homozygous missense mutations in NDRG1 in CMT patients and mentioned the function of NDRG1 in protein recycling, which plays an important role in myelination of the peripheral nerve system.

  8. NDRG1 over-expression promoted apoptosis in colorectal cancer cells whereas depletion of NDRG1 resulted in resistance to oxaliplatin treatment.

  9. HCV coopts the MYC pathway responsible for NDRG1 expression and phosphorylation that regulates lipid droplet formation and metabolism. NDRG1 appears to restrict HCV by suppressing the lipid droplet formation that is necessary for HCV assembly.

  10. these data show that NDRG1 is regulated by the oncogenic MAP kinase (show MAPK1 Proteins)-interacting kinase pathway, a target for cancer therapy

Mouse (Murine) N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. NDR1 interacts with TRAF3 and interferes with the association of TRAF3 and IL-17R, resulting in increased formation of the activation complex IL-17R-Act1, which is required for the downstream signaling and production of pro-inflammatory factors

  2. NDR1 (show STK38 Proteins) kinase, activated by the Rap1 (show TERF2IP Proteins) signaling cascade through RAPL (show RASSF5 Proteins) and Mst1 (show MST1 Proteins)/Mst2 (show STK3 Proteins), associated with and recruited kindlin-3 (show FERMT3 Proteins) to the immunological synapses, which was required for high-affinity LFA-1 (show ITGAL Proteins)/ICAM-1 (show ICAM1 Proteins) binding.

  3. Snell, GHKRO, and PAPPA (show PAPPA Proteins)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (show MGMT Proteins)) and N-myc downstream-regulated gene 1 (NDRG1).

  4. NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis. This study strongly suggests the crucial role of NDRG1 in differentiation process for macrophages.

  5. Using double knockout of NDR1 (show STK38 Proteins) and 2 shows that NDRs acted downstream of MST1 (show MST1 Proteins) to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes.

  6. Ndrg1 is phosphorylated and degraded by CD28 (show CD28 Proteins) signalling in a proteasome-dependent manner.

  7. Ndr1 (show STK38 Proteins)/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR (show STK38 Proteins) kinases are critically required during the early phase of organogenesis

  8. Rassf5 (show RASSF5 Proteins) and Ndr1 (show STK38 Proteins) or Ndr2 (show STK38L Proteins) kinases regulate neuronal polarity through Par3 (show F2RL2 Proteins) phosphorylation.

  9. NDRG1 promotes fetal growth and regulates the metabolic response to intrauterine hypoxic injury in a sexually dichotomous manner

  10. early growth response 1 (show EGR1 Proteins), a transcription factor that binds to the NDRG1 promoter, was mediated in the NDRG1 expression regulation by PKD2 (show PKD2 Proteins).

Zebrafish N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. ndrg1b and fam49ab are 2 new modulators of PTEN signaling that control lymphoid differentiation in the zebrafish thymus.

Arabidopsis thaliana N-Myc Downstream Regulated 1 (NDRG1) interaction partners

  1. NDR1 plays a broad role both in mediating primary cellular functions in Arabidopsis through maintaining the integrity of the cell wall-plasma membrane connection and as a key signaling component of these responses during pathogen infection.

  2. SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.

  3. The induction of defence responses and disease resistance to X. campestris pv. campestris strain 8004 requires NDR1 , RAR1 and SGT1b, suggesting that effector-triggered immunity plays a large role in resistance to this strain.

  4. Sequence analysis and mass spectrometry suggest that NDR1 (show STK38 Proteins) is localized to the PM via a C-terminal glycosylphosphatidyl-inositol (GPI (show GPI Proteins)) anchor.

  5. demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae

  6. Mutations in NDR1 (show STK38 Proteins) abolished the enhanced resistance of dnd (show DND1 Proteins) mutants against Pseudomonas syringae pv. tomato and Hyaloperonospora parasitica but not Botrytis cinerea.

N-Myc Downstream Regulated 1 (NDRG1) Protein Profile

Protein Summary

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with NDRG1

  • N-myc downstream regulated 1 (NDRG1)
  • N-myc downstream regulated gene 1 (Ndrg1)
  • N-myc downstream regulated 1 (Ndrg1)
  • N-myc downstream regulated 1 S homeolog (ndrg1.S)
  • N-myc downstream regulated 1 (ndrg1)
  • N-myc downstream regulated 1a (ndrg1a)
  • Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family (NDR1)
  • N-myc downstream regulated 1 L homeolog (ndrg1.L)
  • N-myc downstream regulated 1b (ndrg1b)
  • cap43 protein
  • cb775 protein
  • cmt4d protein
  • DRG-1 protein
  • drg1 protein
  • gc4 protein
  • hmsnl protein
  • ndr1 protein
  • NDRG1 protein
  • ndrg1-a protein
  • ndrg1-b protein
  • ndrg1l protein
  • ndrg4 protein
  • Ndrl protein
  • nmsl protein
  • non race-specific disease resistance 1 protein
  • proxy1 protein
  • rit42 protein
  • rtp protein
  • targ1 protein
  • tdd5 protein
  • wu:fb60h02 protein
  • xndrg1 protein
  • xNDRG1-A protein
  • zgc:63944 protein
  • zgc:73047 protein

Protein level used designations for NDRG1

N-myc downstream-regulated gene 1 protein , differentiation-related gene 1 protein , nickel-specific induction protein Cap43 , protein NDRG1 , protein regulated by oxygen-1 , reducing agents and tunicamycin-responsive protein , N-myc downstream regulated 1 , protein Ndr1 , N-myc downstream regulated gene 1 , protein NDRG1-B , xNDRG1-B , protein NDRG1-like , protein NDRG1-A , xNDRG1-A , N-myc downstream regulated gene 1, like , N-myc downstream regulated gene 1b , n-myc downstream-regulated gene 1b

10397 Homo sapiens
17988 Mus musculus
299923 Rattus norvegicus
380319 Xenopus laevis
420321 Gallus gallus
464411 Pan troglodytes
482049 Canis lupus familiaris
493508 Xenopus (Silurana) tropicalis
504499 Bos taurus
792085 Danio rerio
100068997 Equus caballus
100230327 Taeniopygia guttata
100401077 Callithrix jacchus
100466806 Ailuropoda melanoleuca
100596235 Nomascus leucogenys
697752 Macaca mulatta
821607 Arabidopsis thaliana
100728790 Cavia porcellus
447720 Xenopus laevis
393665 Danio rerio
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