anti-NUAK Family, SNF1-Like Kinase, 2 (NUAK2) Antibodies

Stress-activated kinase involved in tolerance to glucose starvation. Additionally we are shipping NUAK Family, SNF1-Like Kinase, 2 Proteins (9) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NUAK2 81788 Q9H093
NUAK2 74137 Q8BZN4
NUAK2 289419 Q66HE5
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Top anti-NUAK Family, SNF1-Like Kinase, 2 Antibodies at antibodies-online.com

Showing 10 out of 79 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: NUAK2 Antibody [NBP1-81880] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY403100) Immunohistochemistry-Paraffin: NUAK2 Antibody [NBP1-81880] - Staining of human vulva/anal skin shows strong nuclear positivity in squamous epithelial cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated EIA, WB NUAK2 Antibody western blot analysis in mouse NIH-3T3 cell line lysates (35µg/lane).This demonstrates the NUAK2 antibody detected the NUAK2 protein (arrow). NUAK2 Antibody western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the NUAK2 antibody detected the NUAK2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of NUAK2 (arrow) using rabbit polyclonal NUAK2 Antibody (N-term) (ABIN391234). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the NUAK2 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB NUAK2 Antibody (ABIN654123) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the NUAK2 antibody detected the NUAK2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of NIH-3T3 cell lysate, using NUAK2 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276493 at 1/100 staining Human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged NUAK2 is 1 ng/ml as a capture antibody. Western Blot analysis of NUAK2 expression in transfected 293T cell line by NUAK2 monoclonal antibody (M04), clone 2F9.Lane 1: NUAK2 transfected lysate (Predicted MW: 69.6 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of rat liver, using NUAK2 antibody (ABIN1873980) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s. 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Mouse Un-conjugated WB NUAK2 Antibody  western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the NUAK2 antibody detected the NUAK2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of NUAK2 expression in NT2D1 whole cell lysate ,The lane on the left is treated with the antigen-specific peptide. ABIN6273801 at 1/100 staining Rat kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti NUAK2 Polyclonal Antibody, Unconjugated (ABIN715106) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$317.90
Details

Top referenced anti-NUAK Family, SNF1-Like Kinase, 2 Antibodies

  1. Human Polyclonal NUAK2 Primary Antibody for ICC, IF - ABIN4340883 : Kim, Lee, Chae, Kang, Lee, Oh, Kim, Kim, Kim: Association between phosphorylated AMP-activated protein kinase and MAPK3/1 expression and prognosis for patients with gastric cancer. in Oncology 2013 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal NUAK2 Primary Antibody for ELISA, WB - ABIN543678 : Lefebvre, Bai, Shahmolky, Sharma, Poon, Drucker, Rosen: Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. in The Biochemical journal 2001 (PubMed)

  3. Human Polyclonal NUAK2 Primary Antibody for WB - ABIN391234 : Yamamoto, Takashima, Shintani, Yamazaki, Seguchi, Nakano, Higo, Kato, Liao, Asano, Minamino, Matsumura, Takeda, Kitakaze: Identification of a novel substrate for TNFalpha-induced kinase NUAK2. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 Pubmed References

More Antibodies against NUAK Family, SNF1-Like Kinase, 2 Interaction Partners

Human NUAK Family, SNF1-Like Kinase, 2 (NUAK2) interaction partners

  1. Data (including data from studies in knockout and transgenic mice) suggest that NUAK2/SNARK is involved in both adipose inflammation and energy metabolism in adipocytes; additionally, genome-wide association studies suggest that 2 SNPs in NUAK2/SNARK (rs4682880, rs4682676) are associated with obesity in women.

  2. miR143 inhibited the proliferation, migration and invasion of the glioblastoma cells by degrading NUAK2 in glioblastoma.

  3. Sucrose non-fermenting AMPK related kinase/Pentraxin 3 combined role in immunometabolic signaling and DNA damage response is proposed to accelerate cardiovascular complications in systemic lupus erythematosus patients

  4. NUAK2 silencing and inactivation of the PI3K pathway efficiently controlled CDK2 expression, whereas CDK2 inactivation specifically abrogated the growth of NUAK2-amplified and PTEN-deficient melanoma cells.

  5. The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-beta signaling.

  6. Activation of AMP-activated protein kinase protects the integrity of the blood-brain barrier by suppressing the induction of NADPH oxidase-derived superoxide anions.

  7. Considers possible roles of NUAK2 in tumorigenesis in general and suggest that NUAK2 has pivotal roles in acral melanomagenesis.

  8. MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP (myosin phosphatase Rho-interacting protein) and the inducible kinase NUAK2

  9. This study further supports the importance of NUAK2 in cancer development and tumor progression, while AMPK has antioncogenic properties.

  10. Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.

  11. SNARK is an NF-kappaB-regulated anti-apoptotic gene that contributes to the tumor-promoting activity of CD95 in apoptosis-resistant tumor cells

  12. These data suggests different phosphorylation and regulation of MYPT1 activity by NUAK2.

  13. EBV LMP1 upregulated the expression of SNARK; SNARK expression increased drug resistance in response to doxorubicin increased of cancer cell survival

  14. The nuclear localizing SNARK altered transcriptome profiles and a considerable part of these alterations were canceled by the mutation of NLS, suggesting the ability of SNARK to modulate gene expression dependent on its nuclear localization.

  15. Skeletal muscle SNARK expression is increased in human obesity, and in response to metabolic stressors, but not type 2 diabetes. Partial SNARK depletion failed to modify either glucose or lipid metabolism.

  16. This study describes the cloning and characterization of the rat SNARK homolog, mapping of the human SNARK gene to 1q32, and a potential functional role as mediator of the cellular response to metabolic stress.

Mouse (Murine) NUAK Family, SNF1-Like Kinase, 2 (NUAK2) interaction partners

  1. Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo.

  2. Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes.

  3. These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age.

  4. NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.

  5. Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.

  6. Obesity was a risk factor for colorectal tumorigenesis in Snark(+/-) mice model.

NUAK Family, SNF1-Like Kinase, 2 (NUAK2) Antigen Profile

Protein Summary

Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity).

Gene names and symbols associated with NUAK2

  • NUAK family kinase 2 (NUAK2) antibody
  • NUAK family, SNF1-like kinase, 2 (Nuak2) antibody
  • NUAK family kinase 2 (Nuak2) antibody
  • 1200013b22rik antibody
  • mKIAA0537 antibody
  • Omphk2 antibody
  • Snark antibody
  • UV126 antibody

Protein level used designations for NUAK2

NUAK family SNF1-like kinase 2 , SNF1/AMP activated protein kinase , SNF1/AMP kinase-related kinase , omphalocele kinase 2 , SNF1/AMP-activated protein kinase

GENE ID SPECIES
81788 Homo sapiens
74137 Mus musculus
488570 Canis lupus familiaris
518632 Bos taurus
289419 Rattus norvegicus
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