Niemann-Pick Disease, Type C1 Proteins (NPC1)

NPC1 encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. Additionally we are shipping NPC1 Antibodies (74) and NPC1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPC1 18145 O35604
NPC1 4864 O15118
Rat NPC1 NPC1 266732  
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Top NPC1 Proteins at antibodies-online.com

Showing 6 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Human Cells Human DYKDDDDK Tag,His tag SDS-PAGE 100 μg Log in to see 20 to 21 Days
$437.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

NPC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , ,
, , ,

More Proteins for Niemann-Pick Disease, Type C1 (NPC1) Interaction Partners

Zebrafish Niemann-Pick Disease, Type C1 (NPC1) interaction partners

Rabbit Niemann-Pick Disease, Type C1 (NPC1) interaction partners

Mouse (Murine) Niemann-Pick Disease, Type C1 (NPC1) interaction partners

Human Niemann-Pick Disease, Type C1 (NPC1) interaction partners

NPC1 Protein Profile

Protein Summary

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

Gene names and symbols associated with NPC1

  • NPC intracellular cholesterol transporter 1 (NPC1)
  • Niemann-Pick disease, type C1 (npc1)
  • Niemann-Pick C1 protein (LOC579887)
  • NPC intracellular cholesterol transporter 1 (Npc1)
  • A430089E03Rik protein
  • C85354 protein
  • Cdig2 protein
  • D18Ertd139e protein
  • D18Ertd723e protein
  • im:7149020 protein
  • lcsd protein
  • nmf164 protein
  • NPC protein
  • spm protein
  • wu:fb53a12 protein
  • wu:fc29a12 protein

Protein level used designations for NPC1

Niemann-Pick C1 protein , Niemann-Pick type C1 disease protein , Nasopharyngeal carcinoma 1 , Niemann-Pick C1 , Niemann-Pick disease, type C1 , sphingomyelinosis , Niemann-Pick C disease protein

GENE ID SPECIES
403698 Canis lupus familiaris
455338 Pan troglodytes
493693 Felis catus
553330 Danio rerio
579887 Strongylocentrotus purpuratus
100008746 Oryctolagus cuniculus
18145 Mus musculus
4864 Homo sapiens
397591 Sus scrofa
421076 Gallus gallus
266732 Rattus norvegicus
100718604 Cavia porcellus
Selected quality suppliers for NPC1 Proteins (NPC1)
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