NPC1 Protein (His tag,DYKDDDDK Tag)
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- Target See all NPC1 Proteins
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NPC1 protein is labelled with His tag,DYKDDDDK Tag.
- Purpose
- Recombinant Human NPC1 Protein (His & FLAG Tag)
- Sequence
- Arg372-Phe622
- Characteristics
- A DNA sequence encoding the human NPC1 (NP_000262.2) (Arg372-Phe622) was expressed with a N-terminal polyhistide-tagged FLAG tag at the N-terminus (his-FLAG).
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product NPC1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
- Alternative Name
- NPC1 (NPC1 Products)
- Synonyms
- NPC Protein, 9130221N23Rik Protein, Gm243 Protein, Cdig2 Protein, im:7149020 Protein, wu:fb53a12 Protein, wu:fc29a12 Protein, A430089E03Rik Protein, C85354 Protein, D18Ertd139e Protein, D18Ertd723e Protein, lcsd Protein, nmf164 Protein, spm Protein, NPC intracellular cholesterol transporter 1 Protein, NPC1 like intracellular cholesterol transporter 1 Protein, Niemann-Pick disease, type C1 Protein, Niemann-Pick C1 protein Protein, NPC1 Protein, Npc1l1 Protein, Npc1 Protein, npc1 Protein, LOC579887 Protein
- Background
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Background: Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL.The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick type C1. NPC1 localizes predominantly to late endosomes and has a dileucine motif located within a small cytoplasmic tail thought to target the protein to this location.Niemann-Pick disease Type C1 (NPC1) is a rare progressive neurodegenerative disorder caused by mutations in the NPC1 gene. On the cellular level NPC1 mutations lead to an accumulation of cholesterol and gangliosides.
Synonym: NPC
- Molecular Weight
- 32 kDa
- NCBI Accession
- NP_000262
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