anti-Non-POU Domain Containing, Octamer-Binding (NONO) Antibodies

NONO encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. Additionally we are shipping NONO Proteins (8) and NONO Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NONO 4841 Q15233
NONO 317259 Q5FVM4
NONO 53610 Q99K48
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Top anti-NONO Antibodies at

Showing 10 out of 121 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IF, WB <b>WB Suggested Anti-NONO Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Dog Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 7 to 9 Days
Cow Rabbit Un-conjugated IF, IHC, WB <b>WB Suggested Anti-NONO Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Dog Mouse Un-conjugated IF, IHC (p), WB 100 μL Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC (p), WB NONO Antibody (N-term) (ABIN657703) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the NONO antibody detected the NONO protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated IHC, IHC (p), IP, PLA, WB Detection of Human NONO by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 1/4 of IP reaction loaded) and 293T (T, 50 mcg) cells. Antibodies: Affinity purified rabbit anti-NONO antibody ABIN151100 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. NONO was also immunoprecipitated using anti-NONO antibody ABIN151095 at 3 mcg/mg lysate. Detection: Chemiluminescence with exposure times of 10 seconds (A and B). Western Blot: NONO Antibody [ABIN151100] - Whole cell lysate NIH3T3, TCMK-1, 4T1, CT26.WT, and rat C6 cells. 0.1 mL Log in to see 7 to 9 Days
Dog Mouse Un-conjugated BI, WB Western blot analysis of p54 [nrb] on a Jurkat lysate. Lane 1: 1:2500, lane 2: 1:5000, lane 3: 1:10000 dilution of the p54 [nrb] antibody. Immunofluorescent staining of A549 (ATCC CCL-185) cells. Cells were seeded in a 96 well imaging plate at ~ 10 000 cells per well. After overnight incubation, cells were stained using the alcohol perm protocol and the anti-p54 [nrb] antibody. The second step reagent was FITC goat anti mouse Ig. The image was taken on a BD Pathway™ 855 Bioimager using a 20x objective. This antibody also stained HeLa (ATCC CCL-2) and U-2 OS (ATCC HTB-96) cells using both the Triton™ X-100 and alcohol perm protocols. 150 μg Log in to see 6 to 8 Days
Human Goat Un-conjugated IHC, ELISA, WB ABIN185629 (0.1µg/ml) staining of mouse brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , 10% SDS PAGE antibody diluted at 1:1000 IHC-P Image p54/nrb antibody detects p54/nrb protein at nucleus in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. p54/nrb antibody , diluted at 1:500. 100 μL Log in to see 1 to 2 Days
Human Rabbit Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 6 Days

NONO Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NONO Antibodies

  1. Dog (Canine) Monoclonal NONO Primary Antibody for BI, WB - ABIN968450 : Basu, Dong, Krainer, Howe: The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO. in Molecular and cellular biology 1997 (PubMed)
    Show all 3 Pubmed References

  2. Dog (Canine) Monoclonal NONO Primary Antibody for BI, WB - ABIN968451 : Dong, Horowitz, Kobayashi, Krainer: Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. in Nucleic acids research 1993 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal NONO Primary Antibody for IHC, IHC (p) - ABIN151100 : Zhang, Zhang, Shen, Burks, Zhang, Wang, LeMaire, Yoshimura, Aoki, Coselli, Wang: TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway. in Arteriosclerosis, thrombosis, and vascular biology 2007 (PubMed)
    Show all 3 Pubmed References

  4. Cow (Bovine) Polyclonal NONO Primary Antibody for IF, WB - ABIN2779027 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal NONO Primary Antibody for IHC (p), IHC - ABIN251463 : Brown, Ripperger, Kadener, Fleury-Olela, Vilbois, Rosbash, Schibler: PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. in Science (New York, N.Y.) 2005 (PubMed)

  6. Cow (Bovine) Polyclonal NONO Primary Antibody for IF, IHC - ABIN2779028 : Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ... in Genome research 2006 (PubMed)
    Show all 2 Pubmed References

More Antibodies against NONO Interaction Partners

Human Non-POU Domain Containing, Octamer-Binding (NONO) interaction partners

  1. GAPLINC has a role in promoting colorectal cancer invasion via binding to PSF/NONO and partly by stimulating the expression of SNAI2

  2. Here, it is reported that l-proline stabilizes purified NONO homodimers, enabling good-quality solution small-angle X-ray structure determination and crystallization. NONO crystallized in the apparent space group P21 (show CDKN1A Antibodies) with a unique axis (b) of 408.9 A and with evidence of twinning, as indicated by the cumulative intensity distribution L statistic, suggesting the possibility of space group P1.

  3. Mechanistic dissection reveals that NEAT1 broadly interacts with the NONO-PSF (show IGFBP7 Antibodies) heterodimer as well as many other RNA-binding proteins and that multiple RNA segments in NEAT1, including a 'pseudo pri-miRNA' near its 3' end, help attract the Drosha (show DROSHA Antibodies)-DGCR8 (show DGCR8 Antibodies) Microprocessor.

  4. The SFPQ (show SFPQ Antibodies)*NONO complex contains an RNA binding domain, and prior work has demonstrated diverse roles in RNA metabolism. It is thus plausible that the additional repair function of NONO, revealed in cell-based assays, could involve RNA interaction.

  5. NEAT1-associated paraspeckle proteins P54nrb and PSF (show IGFBP7 Antibodies) have been reported as positive regulators of c-Myc (show MYC Antibodies) translation through interaction with c-Myc (show MYC Antibodies) IRES

  6. Exome analysis identified a novel de novo splice-site variant c.1171+1G>T in exon 11 of NONO gene in a patient with intellectual disability and non-compaction cardiomyopathy.

  7. Case Report: melanotic PEComa of the sinonasal mucosa with NONO-TFE3 (show TFE3 Antibodies) fusion.

  8. High expression of P54 (show DDX6 Antibodies) is associated with breast cancer.

  9. The present study indicates that p54nrb is a powerful molecule involved in the regulation of cell motility and promotes the migration and invasion of THP1 (show GLI2 Antibodies) cells, and it is more likely to be involved in the release of inflammatory mediators and the motility of inflammatory cells.

  10. p54(nrb) is a novel regulator of SREBP-1a in the nucleus, and the data suggest that p54(nrb) regulation of SREBP-1a supports the increased cellular demand of lipids for breast cancer growth.

Mouse (Murine) Non-POU Domain Containing, Octamer-Binding (NONO) interaction partners

  1. These findings argue that Nono collaborates with Erk (show EPHB2 Antibodies) signaling to regulate the integrity of bivalent domains and Mouse embryonic stem cell pluripotency.

  2. NONO deficiency significantly compromises the response to ionizing radiation-induced DNA damage in the testes, consistent with cell type-specific loss of DSB repair capacity. The results provide evidence that this RNA binding protein significantly contributes to the DNA damage response in vivo.

  3. Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1 (show PSPC1 Antibodies))-aldehyde dehydrogenase 1 (NONO/PSPC1 (show PSPC1 Antibodies)-ALDH1A1 (show ALDH1A1 Antibodies)) in the modulation of Sertoli cells (SCs (show TWIST1 Antibodies)) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.

  4. This study provides an improved understanding of the molecular basis (structure and dynamics) that governs the binding of the p54(nrb)/NonO RRM1 (show RRM1 Antibodies) to one of its target RNAs.

  5. mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets

  6. Cytoplasmic granule containing HERMES (show CD44 Antibodies), NonO, PSF (show IL-3 Antibodies), and G3BP1 (show G3BP1 Antibodies) is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.

  7. Quantitative proteomics reveals dynamic interaction of JNK (show MAPK8 Antibodies) with RNA transport granule proteins Sfpq (show SFPQ Antibodies) and Nono during neuronal differentiation

  8. We analyzed the expression of sperm-specific Akap3 (show AKAP3 Antibodies) and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.

  9. NONO genetic insufficiency led to upregulation of PSPC1 (show PSPC1 Antibodies), which replaced NONO in a stable complex with SFPQ (show SFPQ Antibodies).

  10. Dsta indicate that NONO bound to p16-Ink4A cell cycle checkpoint gene and potentiated its circadian activation in a PER protein-dependent fashion.

NONO Antigen Profile

Protein Summary

This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16.

Gene names and symbols associated with NONO

  • non-POU domain containing octamer binding (NONO) antibody
  • non-POU domain containing, octamer-binding (NONO) antibody
  • non-POU domain containing, octamer-binding (Nono) antibody
  • non-POU domain containing, octamer binding L homeolog (nono.L) antibody
  • non-POU-domain-containing, octamer binding protein (Nono) antibody
  • AA407051 antibody
  • AV149256 antibody
  • nmt55 antibody
  • nonA antibody
  • nrb54 antibody
  • P54 antibody
  • p54nrb antibody
  • xp54nrb antibody

Protein level used designations for NONO

54 kDa nuclear RNA- and DNA-binding protein , 55 kDa nuclear protein , DNA-binding p52/p100 complex, 52 kDa subunit , non-POU domain-containing octamer (ATGCAAAT) binding protein , non-POU domain-containing octamer-binding protein , p54(nrb) , non-POU-domain-containing, octamer-binding protein , 54 kD nuclear RNA-binding protein

4841 Homo sapiens
428701 Gallus gallus
612773 Canis lupus familiaris
615175 Bos taurus
317259 Rattus norvegicus
380427 Xenopus laevis
53610 Mus musculus
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