These results reveal a novel role of NRX in the regulation of PFK1 activity and in the balance between glycolysis and the pentose phosphate pathway.
NRX retains a pool of inactive Dishevelled for robust activation of Wnt/beta-catenin signaling upon Wnt stimulation.
Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene
These data suggest a relationship between the Wnt-beta-catenin pathway and redox signalling through redox-sensitive association of NRX with Dvl.
formation of a complex between GST-nucleoredoxin, protein phosphatase 2A (PP2A) (C) and PP2A(D) was demonstrated by pull-down experiments
identified nucleoredoxin as an interaction partner of Sec63; characterized this interaction; Sec63 is linked to the Wnt signaling pathways and this interaction may be the reason why mutations in SEC63 can lead to polycystic liver disease
Nucleoredoxin is a novel thioredoxin family member involved in cell growth and differentiation [review]
Nucleoredoxin regulates the Wnt/planar cell polarity pathway in Xenopus.
Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).
protein Red-1 , nucleoredoxin 1 , nucleoredoxin
GENE ID | SPECIES |
---|---|
18230 | Mus musculus |
64359 | Homo sapiens |
360577 | Rattus norvegicus |
417619 | Gallus gallus |
444590 | Xenopus laevis |
531367 | Bos taurus |
553621 | Danio rerio |
611162 | Canis lupus familiaris |
746905 | Pan troglodytes |
100011801 | Monodelphis domestica |
100216233 | Xenopus (Silurana) tropicalis |
100715515 | Cavia porcellus |