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PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family.
Showing 10 out of 150 products:
Human Monoclonal PBK Primary Antibody for ICC, FACS - ABIN969345
Oh, Zhu, Cho, Lee, Kang, Kim, Zykova, Bode, Dong: T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. in Cancer research 2007
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Human Polyclonal PBK Primary Antibody for WB - ABIN1881635
Zykova, Zhu, Lu, Higgins, Tatsumi, Abe, Bode, Dong: Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Show all 2 Pubmed References
Human Polyclonal PBK Primary Antibody for ICC, IF - ABIN4343992
Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. in Molecular & cellular proteomics : MCP 2009
CDK1 (show CDK1 Antibodies)-mediated mitotic phosphorylation of PDZ-binding kinase is involved in cytokinesis and inhibits its oncogenic activity.
Data suggest that T-LAK cell-originated protein kinase (TOPK) might play a pivotal role in breast cancer invasion and metastasis.
our study provide convincing evidences that FoxM1 (show FOXM1 Antibodies)-regulated PBK exerts oncogenic activities towards HCC (show FAM126A Antibodies) via the activation of beta-Catenin (show CTNNB1 Antibodies) pathway.
High TOPK expression is associated with liver cancer.
The role of T-LAK cell-originated protein kinase directly promotes metastasis of colorectal cancer by modulating p53-related protein kinase (show TP53RK Antibodies).
TOPK protein and transcriptional levels of FOXM1 (show FOXM1 Antibodies) were reduced by TOPK inhibitor treatment.
Results indicate that src (show SRC Antibodies)-family kinase (Src (show SRC Antibodies)) is a upstream kinase of T-LAK cell-originated protein kinase (TOPK).
Upregulation of proteasome subunit beta type 8 PSMB8 (show PSMB8 Antibodies) and PDZ binding kinase PBK was confirmed by real-time reverse transcription-PCR analysis.
MiR (show MLXIP Antibodies)-770-5p and PBK levels were inversely correlated in xenograft model mice.
TOPK knockdown did not alter radiation response in normal tissues, but significantly enhanced radiosensitivity in cancer cells.These findings have clinical relevance, as elevated TOPK protein expression was associated with poorer clinical outcomes in prostate cancer patients treated with radical radiotherapy. TOPK disruption may cause tumour-specific radiosensitisation in multiple different tumour types.
this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN/Akt (show AKT1 Antibodies) signaling pathway
T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (show DUSP1 Antibodies) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (show RNF19A Antibodies) signaling pathway.
The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.
Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.
This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
PDZ binding kinase
, T-LAK cell-originated protein kinase
, MAPKK-like protein kinase
, cancer/testis antigen 84
, lymphokine-activated killer T-cell-originated protein kinase
, serine/threonine protein kinase
, spermatogenesis-related protein kinase
, PDZ-binding kinase
, PBK, PDZ-binding kinase
, lymphokine-activated killer T-cell-originated protein kinase homolog