anti-PDZ Binding Kinase (PBK) Antibodies

PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Additionally we are shipping PDZ Binding Kinase Proteins (12) and PDZ Binding Kinase Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PBK 55872 Q96KB5
PBK 52033 Q9JJ78
PBK 290326  
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Top anti-PDZ Binding Kinase Antibodies at antibodies-online.com

Showing 10 out of 164 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PBK Antibody Titration:  0.2-1 ug/ml  Positive Control:  721_B cell lysate PBK is supported by BioGPS gene expression data to be expressed in 721_B 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- PBK Picoband antibody, IHC(P) IHC(P): Mouse Testis Tissue Anti- PBK Picoband antibody, Western blotting All lanes: Anti PBK  at 0.5ug/ml Lane 1: Rat Testis Tissue Lysate at 50ug Lane 2: Mouse Testis Tissue Lysate at 50ug Lane 3: Human Placenta Tissue Lysate at 50ug Lane 4: JURKAT Whole Cell Lysate at 40ug Predicted bind size: 36KD Observed bind size: 36KD 100 μg 4 to 6 Days
$280.00
Details
Human Mouse Un-conjugated ELISA, FACS, IF/ICC, IHC, WB 100 μL 11 to 16 Days
$469.05
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of Hela cells using PBK mouse mAb (green) and negative control (red) . 100 μL 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated IHC, WB   200 μL 13 to 14 Days
$575.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7 cells, treated with Nocodazole 1ug/ml 16h, using PBK/TOPK (Ab-9) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PBK/TOPK (Ab-9) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from K562 cells treated with UV 30', using PBK/TOPK (Phospho-Thr9) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), WB 100 μg 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Available
$363.46
Details

Top referenced anti-PDZ Binding Kinase Antibodies

  1. Human Polyclonal PBK Primary Antibody for IHC (p), ELISA - ABIN542997 : Zhao, Dai, Zhao, Xia, Zhou, Wang, Gu, Ying, Xie, Mao: PDZ-binding kinase participates in spermatogenesis. in The international journal of biochemistry & cell biology 2001 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal PBK Primary Antibody for ICC, FACS - ABIN969345 : Oh, Zhu, Cho, Lee, Kang, Kim, Zykova, Bode, Dong: T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. in Cancer research 2007 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal PBK Primary Antibody for ICC, IF - ABIN4343992 : Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. in Molecular & cellular proteomics : MCP 2009 (PubMed)

More Antibodies against PDZ Binding Kinase Interaction Partners

Human PDZ Binding Kinase (PBK) interaction partners

  1. Results show that TOPK is highly expressed in hematopoietic tumor cell lines and in primary chronic myeloid leukemia tumors. Its expression induces the kinase activity of BCR/ABL.

  2. PBK/TOPK provides stability of an oncoprotein, c-MYC.

  3. Study identified PDZ binding kinase as a novel gene up-regulated in peritumoural brain zone of glioblastoma (GBM) with a strong role in conferring aggressiveness, including radio-chemoresistance, thus contributing to recurrence in GBM tumours.

  4. Data found that the PBK/TOPK appears to be overexpressed in nucleus or cytoplasm in different colorectal cancer (CRC) patients. Patients with low-scoring and cytoplasmic expression, with negative nuclear expression, and advanced stage, or with low total expression were revealed to have a relatively poor prognosis. PBK/TOPK expression and localization might be used as an independent prognostic marker for CRC patients.

  5. a novel interplay between AR and PBK that results in increased AR and ARVs expression that executes AR-mediated growth and progression of aggressive prostate cancer (PrCa), with implications for the development of PBK inhibitors for the treatment of aggressive PrCa.

  6. Results found that PBK/TOPK was upregulated and phosphorylated in HTLV1-transformed Tcell lines and ATLLderived Tcell lines. In addition, HTLV1 infection upregulated PBK/TOPK expression in PBMCs, suggesting that this kinase increases the rate of mitosis and expands malignant T cells.

  7. Findings strongly suggest that phosphorylated T-lymphokine-activated killer cell-originated protein kinase may be a potent biomarker to determine the outcome of patients with primary central nervous system lymphoma and to develop novel drugs to treat primary central nervous system lymphoma.

  8. the expression of TOPK be a novel alternative biomarker to categorize the malignancy of gliomas.

  9. CDK1-mediated mitotic phosphorylation of PDZ-binding kinase is involved in cytokinesis and inhibits its oncogenic activity.

  10. Data suggest that T-LAK cell-originated protein kinase (TOPK) might play a pivotal role in breast cancer invasion and metastasis.

  11. our study provide convincing evidences that FoxM1-regulated PBK exerts oncogenic activities towards HCC via the activation of beta-Catenin pathway.

  12. High TOPK expression is associated with liver cancer.

  13. The role of T-LAK cell-originated protein kinase directly promotes metastasis of colorectal cancer by modulating p53-related protein kinase.

  14. TOPK protein and transcriptional levels of FOXM1 were reduced by TOPK inhibitor treatment.

  15. Results indicate that src-family kinase (Src) is a upstream kinase of T-LAK cell-originated protein kinase (TOPK).

  16. Upregulation of proteasome subunit beta type 8 PSMB8 and PDZ binding kinase PBK was confirmed by real-time reverse transcription-PCR analysis.

  17. MiR-770-5p and PBK levels were inversely correlated in xenograft model mice.

  18. TOPK knockdown did not alter radiation response in normal tissues, but significantly enhanced radiosensitivity in cancer cells.These findings have clinical relevance, as elevated TOPK protein expression was associated with poorer clinical outcomes in prostate cancer patients treated with radical radiotherapy. TOPK disruption may cause tumour-specific radiosensitisation in multiple different tumour types.

  19. Determined the crystal structure of PBK, which has two phospho-mimicking mutations T9E and T198E. The structural data indicated that PBK may assemble into an inactive dimer in alkaline conditions. Analytical size-exclusion chromatography and analytical ultracentrifugation confirmed that PBK exists in a conformational transition between dimers and monomers at different pH conditions.

  20. PBK/TOPK plays a crucial role in tumour malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer.

Mouse (Murine) PDZ Binding Kinase (PBK) interaction partners

  1. this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN/Akt signaling pathway

  2. T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway.

  3. The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.

  4. Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.

PDZ Binding Kinase (PBK) Antigen Profile

Protein Summary

This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.

Gene names and symbols associated with PBK

  • PDZ binding kinase (PBK) antibody
  • PDZ binding kinase (pbk) antibody
  • PDZ binding kinase (Pbk) antibody
  • PDZ binding kinase L homeolog (pbk.L) antibody
  • 2810434B10Rik antibody
  • AW538537 antibody
  • CT84 antibody
  • D14Ertd732e antibody
  • Nori-3 antibody
  • PBK antibody
  • SPK antibody
  • TOPK antibody
  • zgc:92050 antibody

Protein level used designations for PBK

PDZ binding kinase , T-LAK cell-originated protein kinase , MAPKK-like protein kinase , cancer/testis antigen 84 , lymphokine-activated killer T-cell-originated protein kinase , serine/threonine protein kinase , spermatogenesis-related protein kinase , PDZ-binding kinase , PBK, PDZ-binding kinase , lymphokine-activated killer T-cell-originated protein kinase homolog

GENE ID SPECIES
422003 Gallus gallus
464496 Pan troglodytes
496810 Xenopus (Silurana) tropicalis
713242 Macaca mulatta
100341076 Oryctolagus cuniculus
100587879 Nomascus leucogenys
55872 Homo sapiens
52033 Mus musculus
360218 Danio rerio
496340 Xenopus laevis
477371 Canis lupus familiaris
100141310 Sus scrofa
534781 Bos taurus
290326 Rattus norvegicus
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