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PDLIM2 encodes a member of the ALP subfamily of PDZ-LIM domain proteins.
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Human Polyclonal PDLIM2 Primary Antibody for WB - ABIN528596
Zhao, Yasunaga, Satou, Nakao, Takahashi, Fujii, Matsuoka: Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB. in Blood 2009
Klotho (show KL Antibodies) can modulate inflammation via PDLIM2/NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) pathway in cyclosporine A-induced nephropathy.
Deficiency in PDLIM2 resulted in the accumulation of STAT3 (show STAT3 Antibodies) in the nucleus, enhanced the extent of TH17 cell differentiation, and exacerbated granuloma formation.
Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.
PDLIM2 expression was sufficient to suppress in vitro anchorage-independent growth and in vivo tumor formation of colon cancer. PDLIM2 repression involves promoter methylation.
Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells
SLIM is a novel ubiquitin E3 ligase whose targets include STAT (show STAT1 Antibodies) proteins.
PDLIM2 deficiency resulted in larger amounts of nuclear p65 (show NFkBP65 Antibodies), defective p65 (show NFkBP65 Antibodies) ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli
Stat-interacting LIM protein as the critical Stat (show STAT1 Antibodies) ubiquitin E3 ligase involved in osteopontin (show SPP1 Antibodies) regulation of Stat1 (show STAT1 Antibodies).
Suppression of PDLIM2 expression resulted in decreased cell adhesion, increased NF-kappaB (show NFKB1 Antibodies) transcription reporter activity, and increased LPS (show TLR4 Antibodies)-induced TNF-alpha (show TNF Antibodies) production.
Data indicate that OR3A4 upregulation contributes to metastasis and tumorigenesis in gastric cancer by regulating the activation of PDLIM2, MACC1 (show MACC1 Antibodies), NTN4, and GNB2L1 (show GNB2L1 Antibodies).
We conclude that inactivation of PDLIM2 is a recurrent finding in cHL (show CHRDL1 Antibodies) and ALCL, promotes activation of inflammatory signaling pathways and thereby contributes to their pathogenesis
Data show that shRNA mediated knockdown of PDZ and LIM domain protein 2 (PDLIM2) in both primary meningioma and schwannoma leads to significant reductions in cellular proliferation.
PDLIM2 is epigenetically repressed in ovarian cancer development and inhibition of PDLIM2 promoted ovarian cancer growth both in vivo and in vitro via NOS2-derived nitric oxide signaling, leading to recruitment of M2 type macrophages.
The suppression of PDLIM2 expression significantly reduced cell proliferation, cell growth and neoplasm invasiveness in prostate cancer cells.
epigenetic repression of PDLIM2 can be reversed by 5-aza-2-deoxycytidine and vitamin D to suppress KSHV-associated cancer cell growth
PDLIM2 expression is essential for feedback regulation of the beta1-integrin-RhoA (show RHOA Antibodies) signalling axis and integration of cellular microenvironment signals with gene expression to control the polarity of breast epithelial acini structures.
PDLIM2 integrates cytoskeleton signaling with gene expression in epithelial differentiation by controlling the stability of key transcription factors and COP9 (show COPS8 Antibodies) signalosome activity.
PDLIM2 was a direct target gene of 1,25(OH)2D3
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PDZ and LIM domain protein 2
, PDZ-LIM protein mystique
, STAT-interacting LIM protein
, alpha-actinins and filamin-interacting protein