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PHF2 encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. Additionally we are shipping PHF2 Proteins (3) and and many more products for this protein.
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PHF2 is a negative epigenetic regulator of MK and erythroid differentiation.
Our results demonstrate that the IKAROS promotes PHF2 expression, and suggest that PHF2 (low) expression works with the IKAROS gene deletion to drive oncogenesis of ALL
Frameshift mutations of PHF2 may play a role in tumorigenesis through its TSG inactivation in CRC and GC.
PHF2 acts as a tumor suppressor in association with p53 in cancer development and ensures p53-mediated cell death in response to chemotherapy.
PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.
JARID1B and PHF2 are overexpressed in esophageal squamous cell carcinoma (ESCC) and they may play crucial roles in the course of ESCC initiation and/or progression
the crystal structures of PHF2 Jumonji domain in the absence and presence of additional exogenous metal ions were determined.
Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis.
The paper's findings establish a downstream epigenetic checkpoint, whereby Phf2, through facilitating H3K9me2 demethylation at specific gene promoters, protects liver from the pathogenesis progression of Non-alcoholic Fatty Liver Disease.
these results demonstrate that PHF2 histone demethylase controls adipogenic gene expression during differentiation.
PHF2 enhances osteoblast differentiation by demethylating Runx2, while suppressor of variegation 3-9 homolog 1 (SUV39H1) inhibits bone formation by methylating it.
Arid5b recruits Phf2 to the promoter region of Sox9 target genes and stimulates H3K9me2 demethylation of these genes.
Data from PHF2 knockout mice suggest that PHF2 plays roles in both adipogenesis and neonatal growth/weight gain; PHF2 interacts with promoter region of CEBPA (CCAAT-enhancer binding protein alpha) gene and demethylates histones in chromatin.
histone H3K4 trimethylation by a homeodomain of PHF2 modulates histone demethylation
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
centromere protein 35
, jumonji C domain-containing histone demethylase 1E
, lysine-specific demethylase PHF2
, PHD finger protein 8
, lysine-specific demethylase phf2
, PHD finger protein 2