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PHF2 antibody

PHF2 Reactivity: Human WB, ELISA, IHC, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7117376
  • Target See all PHF2 Antibodies
    PHF2 (PHD Finger Protein 2 (PHF2))
    Reactivity
    • 16
    • 7
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 13
    • 3
    Rabbit
    Clonality
    • 13
    • 3
    Polyclonal
    Conjugate
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PHF2 antibody is un-conjugated
    Application
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    PHD finger protein 2
    Isotype
    IgG
    Top Product
    Discover our top product PHF2 Primary Antibody
  • Application Notes
    WB: 1:200-1:1000, IP: 1:500-1:1000, IHC: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    PHF2 (PHD Finger Protein 2 (PHF2))
    Alternative Name
    PHF2 (PHF2 Products)
    Synonyms
    CENP-35 antibody, GRC5 antibody, JHDM1E antibody, im:4200679 antibody, phf8 antibody, wu:fa14c10 antibody, PHD finger protein 2 antibody, PHF2 antibody, Phf2 antibody, phf2 antibody
    Background
    Synonyms:GRC5, JHDM1E, KIAA0662, PHD finger protein 2, PHF2 Background:Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3(H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3(H3K4me3) at rDNA promoters and promotes expression of rDNA.
    Molecular Weight
    100 kDa, 150 kDa
    Gene ID
    5253
    UniProt
    O75151
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