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Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Additionally we are shipping PYD (Pyrin Domain) Containing 1 Proteins (4) and many more products for this protein.
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Gerbil Polyclonal PYDC1 Primary Antibody for IHC (fro), IP - ABIN537478
Stehlik, Krajewska, Welsh, Krajewski, Godzik, Reed: The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation. in The Biochemical journal 2003
PYDC1 expression is significantly downregulated in human masticatory mucosa during wound healing
Changes in the tertiary structure of mutated pyrin B30.2 domain interrupting the formation of the pyrin-caspase-1 complex are related to the manifestations of Mediterranean familial fever.
X-ray diffraction data were collected to a resolution of 3.6 A from a crystal belonging to the cubic space group P23 with unit-cell parameters a=b=c=94.12 A, alpha=beta=gamma=90.00 degrees .
NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation.
analysis of the 3D structure of human ASC2 protein involved in apoptosis and inflammation
ASC2 is a pyrin domain-only protein that regulates inflammatory signaling
POP1/ASC2 associates with ASC via PAAD-PAAD interactions and modulates NF-kappa B and pro-caspase-1 regulation by this adapter protein
Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
PAAD-only protein 1
, pyrin domain containing 1
, pyrin domain-containing protein 1
, pyrin-domain containing protein 1
, pyrin-only protein 1