anti-Paraoxonase 1 (PON1) Antibodies

The enzyme encoded by PON1 is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Additionally we are shipping Paraoxonase 1 Kits (82) and Paraoxonase 1 Proteins (24) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PON1 5444 P27169
PON1 18979 P52430
PON1 84024 P55159
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Top anti-Paraoxonase 1 Antibodies at antibodies-online.com

Showing 10 out of 201 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-PON1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  HT1080 cell lysate Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5µg/ml using anti-PON1 antibody (ARP41400_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PON1 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB EB09286 (1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Mouse Rabbit Un-conjugated IHC (p), WB IHC analysis of PON1 using anti-PON1 antibody . PON1 was detected in paraffin-embedded section of mouse liver tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-PON1 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. IHC analysis of PON1 using anti-PON1 antibody . PON1 was detected in paraffin-embedded section of mouse small intestine tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-PON1 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Mouse Un-conjugated ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using PON1 mAb against human PON1 recombinant protein. (Expected MW is 40.6 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$577.50
Details
Human Mouse Un-conjugated ELISA, FACS, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using PON1 mAb against human PON1 recombinant protein. (Expected MW is 40.6 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$577.50
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of CEM cells using PON1 Antibody (Center) Cat.-No AP53390PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with PON1 Antibody (Center) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. This data demonstrates the use of PON1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Kidney lysate; ;Primary Ab: 3µg/ml Rabbit Anti-Mouse PON1 Antibody;Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(Catalog: SAA544Rb19) 100 μg Log in to see 15 to 18 Days
$324.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Rat Liver Tissue. 100 μg Log in to see 15 to 18 Days
$342.00
Details

Top referenced anti-Paraoxonase 1 Antibodies

  1. Human Monoclonal PON1 Primary Antibody for FACS, IHC - ABIN1724909 : Saadat: Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: a meta-analysis. in Cancer epidemiology 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal PON1 Primary Antibody for ICC, FACS - ABIN1724910 : Yesilova, Turan, Ucmak, Selek, Halil Yavuz, Tanr?kulu: Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress. in Redox report : communications in free radical research 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal PON1 Primary Antibody for IHC, IHC (p) - ABIN4346826 : Lescuyer, Pernin, Hainard, Bigeire, Burgess, Zimmermann-Ivol, Sanchez, Schifferli, Hochstrasser, Moll: Proteomic analysis of a podocyte vesicle-enriched fraction from human normal and pathological urine samples. in Proteomics. Clinical applications 2010 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal PON1 Primary Antibody for ELISA, WB - ABIN562316 : Gupta, Kandimalla, Priyanka, Singh, Gill, Singh: Effect of Resveratrol and Nicotine on PON1 Gene Expression: In Vitro Study. in Indian journal of clinical biochemistry : IJCB 2014 (PubMed)

  5. Human Polyclonal PON1 Primary Antibody for ELISA, WB - ABIN541137 : Bhattacharyya, Nicholls, Topol, Zhang, Yang, Schmitt, Fu, Shao, Brennan, Ellis, Brennan, Allayee, Lusis, Hazen: Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. in JAMA 2008 (PubMed)

  6. Human Monoclonal PON1 Primary Antibody for ELISA, WB - ABIN519040 : Cubedo, Padró, Alonso, Mata, Badimon: ApoL1 levels in high density lipoprotein and cardiovascular event presentation in patients with familial hypercholesterolemia. in Journal of lipid research 2016 (PubMed)

  7. Human Monoclonal PON1 Primary Antibody for WB - ABIN532617 : Akhmedova, Yakimovsky, Schwartz: Paraoxonase 1 Met--Leu 54 polymorphism is associated with Parkinson's disease. in Journal of the neurological sciences 2001 (PubMed)
    Show all 2 Pubmed References

  8. Cow (Bovine) Polyclonal PON1 Primary Antibody for IHC, WB - ABIN2776787 : Penco, Buscema, Patrosso, Marocchi, Grossi: New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. in BMC bioinformatics 2008 (PubMed)

  9. Human Polyclonal PON1 Primary Antibody for FACS, IHC (p) - ABIN654641 : Guglielmetti, Mazza, Pagano, Carrella, Sciuto, Nodari, Pezzolato, Richelmi, Baioni, Caramelli, Acutis, Bozzetta: Identification by a proteomic approach of a plasma protein as a possible biomarker of illicit dexamethasone treatment in veal calves. in Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 2014 (PubMed)

More Antibodies against Paraoxonase 1 Interaction Partners

Human Paraoxonase 1 (PON1) interaction partners

  1. cefuroxime axetil inhibited competitively in vitro paraoxonase activity of this enzyme. According to this information, we thought that cefuroxime axetil linked to the active site of the enzyme. Fosfomycin and cefaclor monohydrate can be attached with amino acids out of the active site of the enzyme because they inhibit enzyme noncompetitively.

  2. The polymorphisms Q192R and L55M, and the paraoxonase activity of PON1 are not risk factors for atherothrombotic stroke according to the results of this study.

  3. No association between the polymorphisms studied and the risk for MetS was observed. The adiponectin TG genotype may be associated with reduced HDL-C and the human paraoxonase 1 AA genotype with hypertension in males.

  4. Our results reveal associations between rs2237583 and rs3917490 in PON1 and GxG interactions containing rs2237583 and rs17166879 with the susceptibility of nonsyndromic cleft lip with or without cleft palate in the Brazilian population.

  5. The levels of AREase and PONase and the prevalence of PON1-L55M and PON1-Q192R genotypes were similar between the four groups of children, thin, normal weight, overweight and obese.

  6. An interaction between the MTHFR 677 C>T and PON1 192Q>R or PON1 55L>M maternal polymorphisms neither an independent association of MTHFR 677 C>T polymorphism with non-recurrent spontaneous abortion, whereas PON1 55LM/MM maternal genotype increase the odds of this event.

  7. This meta-analysis suggests that the association between the PON1 rs662 polymorphism and coronary heart disease may partly be mediated by abnormal Ox-LDL and lipid levels caused by the R allele.

  8. The meta-analysis suggests that the PON1 rs854560 polymorphism is associated with a lower HDL-C level in Caucasians and subjects of other ethnic origins.

  9. Our study has shown that PON1 - 108 C/T polymorphism might be associated with increased risk of polycystic ovary syndrome under the allelic, homozygote, heterozygote, and dominant models.

  10. PON1 gene Q192R and L55M polymorphisms are not associated with Crimean-Congo hemorrhagic fever.

  11. Minor allele frequencies (MAF) in a Puerto Rican population were 46% for PON1 (rs662), 41% for ABCB1 (rs1045642), 14% for CYP2C19*17, 13% for CYP2C19*2, 12% for P2RY12-H2 and 0.3% for CYP2C19*4. No carriers of the CYP2C19*3 variants were detected. All alleles and genotype proportions were found to be in HardyWeinberg equilibrium (HWE).

  12. results demonstrated increased CETP and decreased LCAT and PON-1 activities in colorectal cancer (CRC)patients. In preliminary analysis CETP mass was identified as potential significant predictor of CRC development, suggesting that alterations in HDL-C levels, alongside with changes in HDL structure might have a role in carcinogenesis.

  13. The single nucleotide polymorphism rs662 of PON1 was not correlated with male infertility, which, however, needs to be confirmed by further studies with larger samples from a larger area.

  14. Results found that total protein concentration and PON1 activity in serum were significantly higher in OA patients. Also, the systemic response to osteoarthritis (serum PON1 activity) was higher about 33.6% in men than women and not dependent on affected joint.

  15. serum levels decrease in states of high oxidative stress like metabolic syndrome, obesity, uncontrolled diabetes, and dyslipidemia

  16. CD was found to be associated with the decrease in the levels of PON-1, which correlates well with activity of the disease and reflects the intensification of inflammation, as well as intensified lipid peroxidation. High sensitivity and specificity of PON-1 determines its selection as a good screening test for CD severity.

  17. The analysis of the effect of the individual SNPs(PON1, IL-6, ITGB3, and ALDH2 ) and GRS groups on different lipid profile parameters revealed no significant association of any of the tested SNPs with any lipid parameter, however, the GRS groups showed marginally significant for TC and highly significant association for TG, LDL-c and HDL-c

  18. It findings provide genetic evidence that the PON1-L55M variant may be a factor contributing to the glycemic control in type 2 diabetes.

  19. Low serum paraoxonase 1 activity is associated with the development of type 2 diabetes mellitus.

  20. T allele and TT genotype are associated with COPD, and the PON1-108C>T polymorphism could be a potential predictor of the disease.

Mouse (Murine) Paraoxonase 1 (PON1) interaction partners

  1. Study shows that PON1 can significantly relieve airway inflammation and airway remolding in asthma mice, and inhibit the secretion of LPS induced macrophage inflammatory cytokines and the proliferation of lung fibroblasts. These results suggest that PON1 may be involved in airway inflammation and remodeling in asthma.

  2. PON1 overexpression protects against AAA progression by reducing oxidative stress, apoptosis and inflammation

  3. Paraoxonase 1 (PON1) influence circadian gene expression and period length

  4. results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL, owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.

  5. Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.

  6. 5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.

  7. HDL (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages.

  8. Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis

  9. The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats.

  10. PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis.

  11. PON1 is not essential for normal development, function, ageing, and the defense against light damage of the mouse retina.

  12. Suggest that PON1 decreases sustained pro-inflammatory reactions, which subsequently can attenuate plaque progression.

  13. PON1 plays a beneficial role in glucose regulation and metabolism and may serve as an important tool in diabetes control.

  14. PON1 activity was found to be increased in diabetic mice after administration of aqueous Murraya koenigii leaves extract.

  15. Pon1 protects mice against Hcy-thiolactone neurotoxicity by hydrolyzing it in the brain.

  16. PON1 is a potent anti-diabetic enzyme that exerts this protection against diabetes through its antioxidative, as well as via its insulin stimulation properties on beta-cells.

  17. antiatherosclerotic properties of HDL can be attributed to two major mechanisms of action of PON1: protecting macrophages from TG-induced oxidative modification and (ii) reduction of peroxide levels in oxidized TGs.

  18. PON1 status plays a critical role in modulating the effects of neonatal chlor- pyrifos oxon exposure in the developing brain.

  19. PON1 status modulates the ability of CaE to detoxicate OP compounds from specific mixed insecticide exposures [review]

  20. analysis of PON1 and oxidative stress in human sepsis and an animal model of sepsis [review]

Pig (Porcine) Paraoxonase 1 (PON1) interaction partners

  1. Western blotting analysis confirmed the presence of PON1 in all boar genital organs, showing in all of them a band of 51 kDa and an extra band of 45 kDa only in seminal vesicles

  2. PON1 behaves as a negative acute phase protein in pigs since a significant decrease (P<0.05) in its activity after 72 h of the induction of the inflammation was observed with all substrates.

Cow (Bovine) Paraoxonase 1 (PON1) interaction partners

  1. This study showed that some polymorphisms of PON1 may provide novel genetic markers for improved fertility in future larger studies in dairy cows.

  2. The PON1 activity in the seminal plasma was positively correlated with ejaculate's colour, sperm mass activity, motility, vigour and viability.Thus, PON1 may be a potential marker for sperm motility and viability in bulls.

  3. The results of this study indicate that there is no effect of serum PON1 activity on the diameter of preovulatory follicle or establishment of pregnancy in cows submitted to time of ovulation synchronization protocols.

  4. characterization the SNPs in the promoter region of the bovine PON1 gene, and to evaluation of association with serum PON1 activity in periparturient Holstein cows

  5. The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.

  6. Data indicate that Cu(2+), Mn(2+), Zn(2+), Ni(2+), and Pb(2+) were found to inhibite the paraoxonase 1 (PON1) enzyme activity in a concentration-dependent fashion.

  7. The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.

  8. The results indicate that lower serum paraoxonase activity and higher concentration of uric acid are associated with oxidative character of transition period and lipid functional antioxidative protection during intensive milk production.

  9. Significantly lower PON1 activity and PON1/high density lipoprotein ratio in lactating cows compared to heifers showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress.

  10. The activity of PON1 and malondialdehyde in late pregnancy and early lactation in dairy cattle is reported.

Rabbit Paraoxonase 1 (PON1) interaction partners

  1. ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity

  2. PON1 can decrease the AChE inhibition, and alleviated clinical signs and tissue damage caused by dichlorvos.

Paraoxonase 1 (PON1) Antigen Profile

Protein Summary

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Gene names and symbols associated with anti-Paraoxonase 1 (PON1) Antibodies

  • paraoxonase 2 (pon2) antibody
  • paraoxonase 1 (PON1) antibody
  • paraoxonase 1 (Pon1) antibody
  • ESA antibody
  • MGC53915 antibody
  • MGC89222 antibody
  • MVCD5 antibody
  • Pon antibody
  • PON1 antibody
  • pon2 antibody

Protein level used designations for anti-Paraoxonase 1 (PON1) Antibodies

paraoxonase 1 , paraoxonase 2 , serum paraoxonase/arylesterase 1-like , A-esterase 1 , K-45 , PON 1 , aromatic esterase 1 , arylesterase B-type , esterase A , paraoxonase B-type , serum aryldiakylphosphatase , serum aryldialkylphosphatase 1 , serum paraoxonase/arylesterase 1 , serum paraoxonase

GENE ID SPECIES
448598 Xenopus (Silurana) tropicalis
463547 Pan troglodytes
699355 Macaca mulatta
100408915 Callithrix jacchus
100436640 Pongo abelii
100602768 Nomascus leucogenys
5444 Homo sapiens
18979 Mus musculus
84024 Rattus norvegicus
475234 Canis lupus familiaris
100048952 Sus scrofa
523798 Bos taurus
100009133 Oryctolagus cuniculus
100721268 Cavia porcellus
101116983 Ovis aries
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