anti-Poly(rC) Binding Protein 2 (PCBP2) Antibodies

The protein encoded by PCBP2 appears to be multifunctional. Additionally we are shipping PCBP2 Proteins (9) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PCBP2 5094 Q15366
PCBP2 18521 Q61990
PCBP2 363005  
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Top anti-PCBP2 Antibodies at antibodies-online.com

Showing 10 out of 66 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-PCBP2 Antibody Titration:  1.25ug/ml  Positive Control:  Jurkat cell lysate There is BioGPS gene expression data showing that PCBP2 is expressed in Jurkat Rabbit Anti-PCBP2 Antibody  Paraffin Embedded Tissue: Human Lung Cellular Data: Alveolar cells Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL 2 to 3 Days
$249.00
Details
Human Mouse Un-conjugated IF, IHC (p), RNAi, ELISA, WB Immunoperoxidase of monoclonal antibody to PCBP2 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to PCBP2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11 to 12 Days
$440.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PCBP2 Antibody Titration:  2.5ug/ml  Positive Control:  HepG2 cell lysate PCBP2 is supported by BioGPS gene expression data to be expressed in HepG2 100 μL 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using PCBP2 antibody. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using PCBP2, antibody at 1:200 dilution. WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , 10% SDS PAGE antibody diluted at 1:500 100 μL 3 to 4 Days
$466.18
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$493.17
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of hnRNP E2 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibo 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of HeLa , using PCBP2antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277250 at 1/100 staining Rat spleen tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Raji 10% SDS PAGE antibody diluted at 1:1000 WB Image Sample (50 ug of whole cell lysate) A: mouse liver 10% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details

Top referenced anti-PCBP2 Antibodies

  1. Human Monoclonal PCBP2 Primary Antibody for IF, IHC (p) - ABIN562121 : Fujimura, Kano, Murata: Identification of PCBP2, a facilitator of IRES-mediated translation, as a novel constituent of stress granules and processing bodies. in RNA (New York, N.Y.) 2008 (PubMed)
    Show all 9 Pubmed References

  2. Cow (Bovine) Polyclonal PCBP2 Primary Antibody for IHC, WB - ABIN2778923 : Oh, Yang, Hahn, Kim, Byun, Jeon, Kim, Song, Noh, Kim, Yoo, Kim, Kim: Transcriptome analysis of human gastric cancer. in Mammalian genome : official journal of the International Mammalian Genome Society 2005 (PubMed)
    Show all 3 Pubmed References

  3. Mouse (Murine) Polyclonal PCBP2 Primary Antibody for IHC, WB - ABIN3023340 : Wu, Lou, Ge, Xiong: Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. in Scientific reports 2018 (PubMed)

  4. Human Polyclonal PCBP2 Primary Antibody for IHC, IHC (p) - ABIN4344022 : Gupta, Singh, Pandey, Seth, Mukhopadhyay: Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation. in Biochimica et biophysica acta. General subjects 2019 (PubMed)

More Antibodies against PCBP2 Interaction Partners

Human Poly(rC) Binding Protein 2 (PCBP2) interaction partners

  1. Results show that PCBP2 interacts with NLRX1 to participate in the NLRX1-induced degradation of MAVS and the inhibition of antiviral responses during HCV infection.

  2. PCBP2 expression was markedly increased in higher stages of glioblastoma compared with those in lower stages; further research suggested that PCBP2 upregulation was connected with poorer prognosis in patients with glioblastoma

  3. Double immunofluorescence for hnRNP E2 and TDP-43 showed most TDP-43 immunopositive dystrophic neuritis within frontal and temporal cortex, and the neuronal cytoplasmic inclusions seen in dentate gyrus granule cells, to contain hnRNP E2. Present findings indicate an association between TDP-43 and hnRNP E2 which might underlie the pathogenetic mechanism of Semantic Dementia Frontotemporal Lobar Degeneration.

  4. Data suggest that the interaction between PCBP2 and the 3'UTR of the ARHGDIA mRNA may induce a local change in RNA structure that favors subsequent binding of miR-151-5p and miR-16, thus leading to the suppression of ARHGDIA expression.

  5. To promote intracellular iron flux, an iron chaperone appears to be essential for receiving iron from heme catabolism. Data suggest that PCBP2 competes with CPR for binding HO1; PCBP2 K homology 3 domain is important for HO1/PCBP2 interaction; heme prompts HO1/CPR multimer and decreases HO1/PCBP2 multimer. [PCBP2 = poly(rC) binding protein 2; CPR = cytochrome P450 reductase; HO1 = heme oxidase 1]

  6. BC200 RNA interacts with hnRNP E1 and E2 mainly through its unique 3' C-rich domain.

  7. Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators.

  8. These results suggest that FPN1 exports iron received from the iron chaperone PCBP2. Therefore, it was found that PCBP2 modulates cellular iron export, which is an important physiological process.

  9. PCBP2 was overexpressed in esophageal squamous cell carcinoma tissues and cell lines. PCBP2 expression promoted proliferation of ESCC cells. We also found that reduced PCBP2 expression might induce ESCC cell apoptosis with increased cleaved caspase3 expression. Overall, our findings indicated that PCBP2 might be involved in the ESCC progression and be considered as a new treatment target in ESCC.

  10. High expression of PCBP2 may contribute to sorafenib resistance in hepatocellular carcinoma cells.

  11. our data indicate that miR-214 may function as tumor suppressor in glioma by targeting PCBP2

  12. alphaCP1/ alphaCP2 binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome.

  13. beta2-adrenergic receptor signaling promotes pancreatic ductal adenocarcinoma progression by facilitating PCBP2-dependent c-myc expression.

  14. PCBP2 knockdown promoted angiotensin II-induced hypertrophy (increase in cell size, protein synthesis and activation of fetal genes) of cardiomyocytes, while PCBP2 overexpression obtained oppose effects.

  15. Protein and mRNA levels of PCBP2 were down-regulated under insulin-resistant conditions. Over-expression of PCBP2 inhibits HIF1alpha and STAT3 pathway.

  16. STAT3 functions via cellular PCBP2 to regulate B-cell lytic susceptibility by restraining Epstein-Barr Virus lytic activation.

  17. PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells.

  18. PCBP2-depletion induces apoptosis in gastric cancer cells via up-regulating expression of pro-apoptotic proteins and down-regulating anti-apoptotic proteins. miR-34a is a target of PCBP2, and miR-34a is critically essential for the function of PCBP2.

  19. SIRT6 inhibits glioma cell proliferation and colony formation in vitro and glioma cell growth in vivo in a PCBP2 dependent manner. SIRT6 inhibits PCBP2 expression through deacetylating H3K9ac and SIRT6 acts as a tumor suppressor in glioma.

  20. Inhibition of poliovirus-induced cleavage of cellular PCBP2 protein reduces the viral RNA replication.

Mouse (Murine) Poly(rC) Binding Protein 2 (PCBP2) interaction partners

  1. Embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage. Compared to wild-type controls, transcript splicing analysis of the Pcbp2(-/-) embryonic liver reveals accentuated exclusion of an exon (exon 6) that encodes a highly conserved transcriptional control segment of the hematopoietic master regulator, Runx1.

  2. These findings suggest that Hr mRNA expression is regulated at the post-transcriptional level via IRES-mediated translation control through interaction with PCPB2, but not in MUHH.

  3. Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators.

  4. data suggest that PCBP2 regulates p73 expression via mRNA stability and p73-dependent biological function in ROS production and cellular senescence.

  5. PCBP2 overexpression rescues the Meis1 effects of Akt-mTOR pathway and hypertrophy of cardiomyocytes.

  6. These data reveal that Pcbp1 and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.

  7. PCBP2 knockdown promoted angiotensin II-induced hypertrophy (increase in cell size, protein synthesis and activation of fetal genes) of cardiomyocytes, while PCBP2 overexpression obtained oppose effects.

  8. Our analysis of PCBP1 and PCBP2 expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.

  9. This study demonstrates for the first time that alpha-CP2 functions as a transcriptional activator by binding to a single-stranded poly(C) sequence.

  10. This study provides evidence that PCBP2 and hnRNP A1 bind to the 5' and 3' ends of the murine norovirus 1 viral RNA and contribute to RNA circularization, playing a role in the virus life cycle.

  11. PCBP2-AIP4 axis defines a new signaling cascade for MAVS degradation and 'fine tuning' of antiviral innate immunity.

Pig (Porcine) Poly(rC) Binding Protein 2 (PCBP2) interaction partners

  1. These results indicated that Nsp1beta of porcine reproductive and respiratory syndrome virus is able to bind and interact with cellular PCBP2 strongly in both the infected cells and plasmid transfected cells.

  2. Overall, the results presented here point toward an important role for PCBP1 and PCBP2 in regulating porcine reproductive and respiratory syndrome virus RNA synthesis via binding to viral nonstructural protein 1beta.

PCBP2 Antigen Profile

Protein Summary

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PCBP2

  • poly(rC) binding protein 2 (PCBP2) antibody
  • poly(rC) binding protein 2 (Pcbp2) antibody
  • poly(rC) binding protein 2 (pcbp2) antibody
  • poly(rC) binding protein 2 L homeolog (pcbp2.L) antibody
  • alphaCP-2 antibody
  • AW412548 antibody
  • fb36h02 antibody
  • hnRNP-E2 antibody
  • HNRNPE2 antibody
  • HNRPE2 antibody
  • Hnrpx antibody
  • PCBP2 antibody
  • PCBP3 antibody
  • wu:fb36h02 antibody
  • zgc:55964 antibody

Protein level used designations for PCBP2

alpha-CP2 , heterogeneous nuclear ribonucleoprotein E2 , heterogenous nuclear ribonucleoprotein E2 , hnRNP E2 , poly(rC)-binding protein 2 , CBP , CTBP , heterogeneous nuclear ribonucleoprotein X , hnRNP X , putative heterogeneous nuclear ribonucleoprotein X , poly(rC) binding protein 2 , poly(rC) binding protein 3 , PolyrC-binding protein 2 , poly(rc)-binding protein 2 , heterogeneous nuclear ribonucleoprotein

GENE ID SPECIES
5094 Homo sapiens
18521 Mus musculus
321844 Danio rerio
363005 Rattus norvegicus
399399 Xenopus laevis
420965 Gallus gallus
477596 Canis lupus familiaris
540653 Bos taurus
733863 Xenopus (Silurana) tropicalis
100194880 Salmo salar
100528911 Ictalurus punctatus
397665 Sus scrofa
100731593 Cavia porcellus
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