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PIGR is a member of the immunoglobulin superfamily. Additionally we are shipping PIGR Proteins (44) and PIGR Kits (31) and many more products for this protein.
Showing 10 out of 143 products:
Human Polyclonal PIGR Primary Antibody for IHC, IHC (p) - ABIN4345568
Trevisi, Gandolfi, Priori, Messori, Colombo, Mazzoni, Lallès, Bosi: Age-related expression of the polymeric immunoglobulin receptor (pIgR) in the gastric mucosa of young pigs. in PLoS ONE 2013
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Mouse (Murine) Polyclonal PIGR Primary Antibody for ELISA - ABIN2000383
Kaetzel: Polymeric Ig receptor: defender of the fort or Trojan horse? in Current biology : CB 2001
Show all 2 Pubmed References
Mouse (Murine) Polyclonal PIGR Primary Antibody for ELISA - ABIN2000385
Shoji, Takahashi, Kurohane, Iwata, Matsuoka, Tsuruta, Sugino, Miyake, Suzuki, Imai: Recombinant Immunoglobulin A Specific for Influenza A Virus Hemagglutinin: Production, Functional Analysis, and Formation of Secretory Immunoglobulin A. in Viral immunology 2015
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Both pIgR and FcRn mRNA levels were significantly reduced in the duodenal mucosa during acute SHIV infection and in the jejunum and caecum during chronic SHIV/SIV infection.
We identified two SLN (show SLN Antibodies) genes (PIGR and TFAP2A (show TFAP2A Antibodies)) that provided high prognostic accuracy in SLN (show SLN Antibodies)-positive melanoma patients (AUC = 0.864). These two SLN (show SLN Antibodies) genes, along with clinicopathological features, can differentiate the high- and low-risk groups in node-positive melanoma patients.
pIgR may be involved in pancreatic ductal adenocarcinoma progression and may be linked stromal activity. Further work on its precise role is mandated in in vivo models, to understand its influence on cancer progression.
RrgA, binds both polymeric immunoglobulin receptor (pIgR) and PECAM-1 (show PECAM1 Antibodies), whereas the choline binding protein PspC binds, but to a lower extent, only pIgR
A genome-wide trans-ethnic interaction study links the PIGR-FCAMR (show FCAMR Antibodies) locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution.
The polymeric immunoglobulin receptor secretory component structure comprises five immunoglobulin-like domains (D1-D5) arranged as a triangle, with an interface between ligand-binding domains D1 and D5.
Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis.
Crohn disease patients were characterized as having decreased median expression of PIGR, in non-inflamed colonic mucosa. By contrast, Ulcerative colitis patients exhibited decreased expression of PIGR in colon mucosa.
These results demonstrate that SLPI (show SLPI Antibodies) down-regulates pIgR expression through the NF-kappaB (show NFKB1 Antibodies) signaling pathway by inhibiting degradation of IkappaBbeta (show NFKBIB Antibodies) protein.
Report PIGR expression in human fallopian tubes, primary epithelial ovarian tumours and metastases.
the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 (show STAT6 Antibodies) pathway activation.
This study evaluated the production of polymeric immunoglobulin receptor and immunoglobulin A in the salivary glands of cattle.
pIgR/SIgA deficiency in the airways leads to persistent activation of innate immune responses to resident lung microbiota, driving progressive small airway remodelling and emphysema.
Increased autoimmune diabetes in Pigr-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.
In a mouse intestinal explant model, the heat-inactivated potential probiotic BB6378 increases intestinal pIgR expression in a site-specific manner on the epithelium via MyD88 (show MYD88 Antibodies).
pIgR on the blood-brain barrier endothelium may represent a novel pneumococcal adhesion receptor.
Results reveal a novel Yes-EGFR (show EGFR Antibodies)-ERK (show EPHB2 Antibodies)-FIP5 signalling network for regulation of pIgA (show PIGA Antibodies)-pIgR transcytosis.
Blockade of transepithelial transport of dimeric IgA (show IgA Antibodies) in pIgR knockout mice reduces the degree of protection or cross-protection against viral infection, in parallel with a marked increase in serum IgA (show IgA Antibodies) concentration and decrease in nasal IgA (show IgA Antibodies) concentration.
Mice deficient in SIgA have been generated by knocking out the pIgR and assessing their ability to maintain normal mucosal homeostasis and to induce mucosal and systemic immune responses against pathogenic and nonpathogenic stimuli.
Mice that lack expression of the polymeric immunoglobulin receptor have approximately 5-fold more systemic IgA (show IgA Antibodies) and 6-fold less nasal IgA (show IgA Antibodies) antibodies than wild-type mice due to defective IgA (show IgA Antibodies) transport into mucosal tissues.
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells\; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.
polymeric immunoglobulin receptor
, polymeric immunoglobulin receptor-like
, poly-Ig receptor
, polymeric IgA receptor
, hepatocellular carcinoma associated protein TB6
, hepatocellular carcinoma-associated protein TB6
, phosphatidylinositol glycan, class R
, poly-IG receptor