anti-Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) Antibodies

The protein encoded by PLOD3 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. Additionally we are shipping PLOD3 Kits (6) and PLOD3 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PLOD3 26433 Q9R0E1
PLOD3 288583 Q5U367
PLOD3 8985 O60568
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Top anti-PLOD3 Antibodies at antibodies-online.com

Showing 10 out of 52 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PLOD3 Antibody (N-term) in MDA-MB435 cell line lysates (35ug/lane). This demonstrates the PLOD3 antibody detected the PLOD3 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of HepG2 cells, using PLOD3 antibody. ABIN6272878 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 to 16 Days
$350.00
Details
Human Rabbit Un-conjugated WB Western blot analysis in MDA-MB435 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 13 Days
$366.77
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of PLOD3 expression in transfected 293T cell line by PLOD3 MaxPab polyclonal antibody.Lane 1: PLOD3 transfected lysate(81.18 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to PLOD3 on HeLa cell. [antibody concentration 10 ug/ml] 50 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using PLOD3 antibody. 200 μL 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μL 11 to 14 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human appendix with PLOD3 polyclonal antibody  shows moderate cytoplasmic positivity in glandular cells. Western blot analysis of U-251 MG cell lysate using PLOD3 polyclonal antibody . 100 μL 11 to 12 Days
$577.33
Details
Human Rabbit Un-conjugated WB Mouse estis lysates probed with PLOD3 Polyclonal Antibody, Unconjugated  at 1:300 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37˚C. 100 μL 3 to 7 Days
$317.90
Details

Top referenced anti-PLOD3 Antibodies

  1. Human Polyclonal PLOD3 Primary Antibody for IF, WB - ABIN522428 : Amodio, Moltedo, Monteleone, DAmbrosio, Scaloni, Remondelli, Zambrano: Proteomic signatures in thapsigargin-treated hepatoma cells. in Chemical research in toxicology 2011 (PubMed)
    Show all 2 Pubmed References

More Antibodies against PLOD3 Interaction Partners

Zebrafish Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) interaction partners

  1. LH3 directs target-selective motor axon regeneration.

  2. Together these data suggest that Lh3-Collagen18A1 dependent ECM modifications regulate the transition of trunk neural crest cells from a non-segmental sheet like migration mode to a segmental stream migration mode

  3. diwanka (lh3) acts through myotomal type XVIII collagen, a ligand for neural-receptor protein tyrosine phosphatases that guide motor axons

Mouse (Murine) Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) interaction partners

  1. Data indicate that lysyl hydroxylase 3 is essential for the glucosyltion of mannan-binding lectin MBL-A.

  2. LH3 is an important regulator of adiponectin biosynthesis, secretion and activity.

  3. LH3-mediated glucosylation occurs at the specific molecular loci in the type I collagen molecule and plays critical roles in controlling collagen cross-linking, fibrillogenesis, and mineralization.

  4. the major function of LH3 in osteoblasts is to glucosylate galactosylhydroxylysine residues in type I collagen and that an impairment of this LH3 function significantly affects type I collagen fibrillogenesis.

  5. results demonstrate that LH3 is indispensable for biosynthesis of type IV collagen and for basement membrane stability during early development and that loss of LH3's functions leads to embryonic lethality

  6. LH3 is present and active in the extracellular space

  7. LH3 has lysyl hydroxylase and galactosylhydroxylysyl glucosyltransferase T activities in vivo, and is essential for the formation of the basement membrane

  8. Results report an important role for lysyl hydroxylase 3 in the organization of the extracellular matrix (ECM) and cytoskeleton.

Human Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) interaction partners

  1. VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified post-Golgi collagen IV carriers

  2. Proteomic analysis revealed that PLOD3, which is the gene encoding for collagen-modifying lysyl hydroxylase 3 (LH3), is regulated by miR-663a.

  3. The study shows that lysyl hydroxylase 3 localizes to epidermal basement membrane and is reduced in patients with recessive dystrophic epidermolysis bullosa.

  4. MMP-9 recruitment to the fibroblast cell surface by Lysyl Hydroxylase 3 (LH3) triggers TGF-beta activation and fibroblast differentiation

  5. LH3 molecules found in the cell medium are secreted through the Golgi complex, and the secretion is dependent on LH3 glycosyltransferase activity; LH3 found on the cell surface bypasses the Golgi complex

  6. Dimerization of human lysyl hydroxylase 3 is mediated by the amino acids 541-547

  7. Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity

  8. Manipulation of the gene for LH3 can be used to selectively alter glycosylation and hydroxylation reactions, and provides new tool to clarify functions of unique hydroxylysine linked carbohydrates in collagens and other proteins.

  9. LH3 is present and active in the extracellular space

  10. The deficiency of LH3 glycosyltransferase activities, especially in the extracellular space, causes growth arrest.

  11. mutations of the lysyl hydroxylase 3 gene may cause a connective tissue disorder [case report]

PLOD3 Antigen Profile

Protein Summary

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity.

Gene names and symbols associated with PLOD3

  • procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 L homeolog (plod3.L) antibody
  • procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3) antibody
  • procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (plod3) antibody
  • procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) antibody
  • procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (Plod3) antibody
  • AI414586 antibody
  • cb479 antibody
  • cb816 antibody
  • diwanka antibody
  • DKFZp469I0226 antibody
  • im:6912725 antibody
  • LH3 antibody
  • plod antibody
  • PLOD3 antibody
  • wu:fb72f10 antibody

Protein level used designations for PLOD3

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 , procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 , diw , lh3 , procollagen-lysine,2-oxoglutarate 5-dioxygenase 3-like , lysyl hydroxylase 2 , lysyl hydroxylase 3 , LH3 , bone protein I (BP-I) , lysine hydroxylase 3 , lysyl hydroxlase 3

GENE ID SPECIES
380138 Xenopus laevis
463618 Pan troglodytes
479730 Canis lupus familiaris
514996 Bos taurus
556077 Danio rerio
734090 Xenopus (Silurana) tropicalis
100059479 Equus caballus
100173058 Pongo abelii
100390092 Callithrix jacchus
26433 Mus musculus
288583 Rattus norvegicus
8985 Homo sapiens
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