Prolylcarboxypeptidase Proteins (PRCP)

The protein encoded by PRCP is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. Additionally we are shipping Prolylcarboxypeptidase Antibodies (80) and Prolylcarboxypeptidase Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRCP 72461 Q7TMR0
PRCP 5547 P42785
PRCP 293118  
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Top Prolylcarboxypeptidase Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg 15 to 18 Days
$640.00
Details
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg 15 to 18 Days
$752.00
Details
Wheat germ Human GST tag 2 μg 11 to 12 Days
$230.67
Details
Human Cells Human His tag   50 μg 4 Days
$522.50
Details
Human Cells Human His tag   10 μg 15 to 16 Days
$300.00
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg 11 Days
$291.50
Details
Yeast Cow His tag   1 mg 60 to 71 Days
$3,268.83
Details
Escherichia coli (E. coli) Mouse GST tag,His tag 100 μg 15 to 18 Days
$704.00
Details

PRCP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , ,
, ,
Rat (Rattus)

More Proteins for Prolylcarboxypeptidase (PRCP) Interaction Partners

Mouse (Murine) Prolylcarboxypeptidase (PRCP) interaction partners

  1. PRCP in Agouti-related peptide neurons contributes to the modulation of alpha-MSH degradation, food intake and body weight.

  2. Prolylcarboxypeptidase (PRCP) converts AngII to Ang (1-7) but only at an acidic pH. Global PRCP deficiency causes heart and kidney alterations and a moderate rise in BP. PRCP is abundant in the kidney collecting tubules, where the prevailing pH is low. In collecting tubules, PRCP deficiency could result in impaired AngII degradation. Increased AngII at this nephron site stimulates Na reabsorption and increases BP.

  3. activity and expression in plasma and lung tissue stays unaffected in lung ischemia-reperfusion injury

  4. This study demonistrated that PRCP gene is broadly expressed in the brain.

  5. PRCP regulates cell growth, angiogenesis, and the response to vascular injury

  6. ACE2 metabolizes ANG II in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH.

  7. PRCP is an important regulator of energy and glucose homeostasis since its deletion significantly improves metabolic parameters in mice exposed to both standard chow diet and high-fat diet

  8. analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors

  9. This study showed that PRCP mutant mice have a significant decrease in fat mass, although an increase in lean mass was also observed; reduced leptin levels and increased energy expenditure were also found.

  10. Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.

  11. PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels.

Human Prolylcarboxypeptidase (PRCP) interaction partners

  1. Using multiple -omics approach, study validated key molecules, such as CAP1, SHC1 and PRCP, that might play a significant role in IgA nephropathy pathogenesis.

  2. For the first time, PRCP is identified as an apelin-cleaving enzyme.

  3. The decrease in PRCP levels in the first 24 h after stroke onset is associated with stroke severity and an unfavourable short-term stroke outcome

  4. PRCP1 interacts with plasma kallikrein (PK) at multiple sites for PK activation.

  5. The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with essential hypertension in Chinese Han population.

  6. PRCP regulates cell growth, angiogenesis, and the response to vascular injury

  7. analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors

  8. PRCP as a resistance factor for 4OHTAM resistance in estrogen receptor-positive breast cancer cells.

  9. A single peptide, with the sequence YPRPIHPA, as a novel substrate for PRCP in human cerebrospinal fluid.

  10. Purified PrCP yielded crystals belonging to space group R32, with unit-cell parameters a = b = 181.14, c = 240.13 A, that diffracted to better than 2.8 A resolution.

  11. A structure-based alignment with the previously undescribed structure of DPP7 illuminates the mechanism of orthogonal substrate specificity of PRCP and DPP7.

  12. Data suggest that the E112D polymorphism in the PRCP gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril treatment in hypertensive patients.

  13. PRCP appears to be a HUVEC-associated prekallikrein activator.

  14. Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator.

  15. recombinant protein, identical to enzyme from human umbilical vein endothelial cells, is a prekallikrein activator.

  16. Prolylcarboxypepdiase E112D (rs2298668)D allele alone and jointly with chronic hypertension were associated with a significantly increased risk of preeclampsia

  17. role in regulation cardiovascular tone; proinflammatory agent

  18. These investigations showed that the C-terminal region of the rPRCP(40) contributes to PRCP's catalytic function, and provided additional experimental evidence for this suggestion.

Prolylcarboxypeptidase (PRCP) Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with Prolylcarboxypeptidase Proteins (PRCP)

  • prolylcarboxypeptidase (prcp)
  • lysosomal Pro-X carboxypeptidase (LOC5579822)
  • prolylcarboxypeptidase (CpipJ_CPIJ006123)
  • prolylcarboxypeptidase (CpipJ_CPIJ006124)
  • prolylcarboxypeptidase (angiotensinase C) (Prcp)
  • prolylcarboxypeptidase (PRCP)
  • prolylcarboxypeptidase (Prcp)
  • prolylcarboxypeptidase (angiotensinase C) (prcp)
  • 2510048K03Rik protein
  • 2610104A14Rik protein
  • AI451719 protein
  • HUMPCP protein
  • MGC145178 protein
  • PCP protein
  • zgc:91816 protein

Protein level used designations for Prolylcarboxypeptidase Proteins (PRCP)

prolylcarboxypeptidase , lysosomal Pro-X carboxypeptidase , proline carboxypeptidase , angiotensinase C , lysosomal carboxypeptidase C , prolylcarboxypeptidase isoform 1 preproprotein

GENE ID SPECIES
780095 Xenopus (Silurana) tropicalis
5579822 Aedes aegypti
6038068 Culex quinquefasciatus
6038069 Culex quinquefasciatus
72461 Mus musculus
5547 Homo sapiens
534927 Bos taurus
293118 Rattus norvegicus
476788 Canis lupus familiaris
100061830 Equus caballus
100734342 Cavia porcellus
436967 Danio rerio
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