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PCSK4 encodes a member of the subtilisin-like proprotein convertase family. Additionally we are shipping PCSK4 Antibodies (55) and PCSK4 Proteins (5) and many more products for this protein.
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Maturation by propeptide removal occurs very inefficiently when rat or human proPCSK4 is overexpressed in HEK293 cells where it interacts with BiP.
abnormal processing of IGF-II by PC4 (show IFRD1 ELISA Kits) may represent a previously uncharacterized mechanism involved in the pathophysiology of fetoplacental growth restriction
These observations indicate that non-histone chromatin-associated proteins like PC4 (show IFRD1 ELISA Kits) play a significant role in neuronal plasticity.
Results suggest that positive cofactor 4 (Pc4 (show SUB1 ELISA Kits)) has an important role in inducing spontaneous somatic cell reprogramming via up-regulation of key pluripotency genes.
CRES (show CST8 ELISA Kits) may be a regulator of PC4 (show IFRD1 ELISA Kits) in sperm-egg interaction and fertilization.
Data suggest that the fertility defect in PCSK4 knockout mice is due, in part, to altered processing/proteolysis of ACRBP (show ACRBP ELISA Kits) (proacrosin/acrosin (show ACR ELISA Kits) binding protein sp32 (show ACRBP ELISA Kits)) as well as structural abnormalities in sperm heads and acrosomes.
thatADAM2may be a natural substrate of sperm PCSK4 and its cleavage by the enzyme during acrosome reaction may be relevant to the fertilization process.
Efficient activation and trafficking of PCSK4 requires a special environment, which presumably exists in testicular germ cells where it is highly expressed, but not in somatic cells where it is not or is barely expressed.
Alterations in signal transduction and proteolytic processing during in vitro capacitation may underlie the fertilization incompetence of PCSK4-null sperm.
PCSK4-null sperm underwent capacitation at a faster rate; they were induced to acrosome react by lower concentrations of zona pellucida; and their egg-binding ability was only half that of wild-type sperm.
Redox-mediated upregulation of hepatocyte iNOS (show NOS2 ELISA Kits) transcription requires an HNF-4alpha (show HNF4A ELISA Kits)-PC4 (show IFRD1 ELISA Kits) transcriptional complex
Report recruitment of RNA polymerase II cofactor PC4 (show IFRD1 ELISA Kits) to DNA damage sites.
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in reproduction and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein (proPACAP) and pro-insulin-like growth factor II.
proprotein convertase subtilisin/kexin type 4
, nerve growth factor-inducible protein PC4
, KEX2-like endoprotease 3
, neuroendocrine convertase 3
, prohormone convertase 3
, NEC 3
, RNA polymerase II transcriptional coactivator
, activated RNA polymerase II transcriptional coactivator p15
, positive cofactor 4
, single-stranded DNA-binding protein p9