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RSPO3 encodes a member of the thrombospondin type 1 repeat supergene family. Additionally we are shipping R-Spondin 3 Antibodies (38) and R-Spondin 3 Kits (10) and many more products for this protein.
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Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK (show PTPRK Proteins)(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT (show WNT2 Proteins) blockade by the porcupine (show PORCN Proteins) inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT (show WNT2 Proteins) pathway inhibitor AXIN1 (show AXIN1 Proteins), with consequent protein loss.
PTPRK (show PTPRK Proteins)-RSPO3 fusions and RNF43 (show RNF43 Proteins) mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs).
Using C-mannosylation-defective Rspo3 mutant-overexpressing cell lines, we found that C-mannosylation of Rspo3 promotes its secretion and activates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
High RSPO3 expression is associated with breast cancer.
A genome-wide association study of bone mineral density (BMD (show BEST1 Proteins)) found a new BMD (show BEST1 Proteins) locus that harbors the PTCH1 (show PTCH1 Proteins) gene, that associates with reduced spine BMD (show BEST1 Proteins) and the RSPO3 associates with increased spine BMD (show BEST1 Proteins).
results suggest that the expression of RSPO (show RSPO1 Proteins) fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population
These findings suggest that aberrant RSPO3-LGR4 (show LGR4 Proteins) signaling potentially acts as a driving mechanism in the aggressiveness of Keap1 (show KEAP1 Proteins)-deficient lung ADs (show AGPS Proteins).
using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 (show RSPO2 Proteins) and RSPO3 that together occur in 10% of colon tumours
the gene is a novel member of thrombospondin type I repeat supergene family (hPWTSR)
a polymorphism in thrombospondin subtly but significantly sensitizes the calcium-binding repeats to removal of Ca2 (show CA2 Proteins)+ and thermal denaturation
H. pylori infection increases stromal R-spondin 3 expression and expands the Axin2 (show AXIN2 Proteins)(+) cell pool to cause hyperproliferation and gland hyperplasia; the ability of stromal niche cells to control and adapt epithelial stem cell dynamics constitutes a sophisticated mechanism that orchestrates epithelial regeneration and maintenance of tissue integrity
We provide in vivo evidence that RSPO3 stimulates the crypt stem cell and niche compartments and drives rapid intestinal tumorigenesis.
Rspo3 function remains essential in adult life to ensure replenishment of lost cells and maintain the properties of the zona glomerulosa
Conditional deletion of Rspo3 in mice disrupts activation of central fate, demonstrating its crucial role in determining and maintaining beta-catenin (show CTNNB1 Proteins)-dependent zonation.
data identify endothelial RSPO3-driven non-canonical WNT (show WNT2 Proteins)/Ca(2 (show CA2 Proteins)+)/NFAT (show NFATC1 Proteins) signaling as a critical maintenance pathway of the remodeling vasculature
Nkx2-5 (show NKX2-5 Proteins) has a role in regulating cardiac growth through modulation of Wnt (show WNT2 Proteins) signaling by R-spondin3
Rspo3 loss of function mutation in combination with Rspo2 (show RSPO2 Proteins) mutation,but not on its own, causes severe limb truncation.
Sexually dimorphic expression patterns were observed for WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-responsive genes, and for Wnt2b (show WNT2B Proteins), Wnt4 (show WNT4 Proteins), Wnt7a (show WNT7A Proteins), Wnt9b (show WNT9B Proteins), Wnt10b (show WNT10B Proteins), Wnt11 (show WNT11 Proteins), Wnt16 (show WNT16 Proteins), and Rspo3 mRNAs.
Data show that Rspo3 binds syndecan 4 (show SDC4 Proteins) and that together they activate Wnt5a (show WNT5A Proteins)/PCP (show BMP1 Proteins) signaling.
suggest a critical role for Rspo3 in the interaction between chorion and allantois in labyrinthine development
This gene encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.
, R-spondin 3 homolog
, protein with TSP type-1 repeat
, roof plate-specific spondin-3
, thrombospondin type-1 domain-containing protein 2
, thrombospondin, type I, domain containing 2
, R-spondin 3-like protein
, cristin 1
, cysteine-rich and single thrombospondin domain-containing protein 1
, thrombospondin, type I, domain 2