RAP1 GTPase Activating Protein Proteins (RAP1GAP)

RAP1GAP encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. Additionally we are shipping RAP1 GTPase Activating Protein Antibodies (58) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RAP1GAP 5909 P47736
RAP1GAP 110351  
Rat RAP1GAP RAP1GAP 313644  
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Top RAP1 GTPase Activating Protein Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 2 μg 11 to 12 Days

RAP1GAP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for RAP1 GTPase Activating Protein (RAP1GAP) Interaction Partners

Human RAP1 GTPase Activating Protein (RAP1GAP) interaction partners

  1. This is the first mechanistic study of Rap1Gap in breast cancer progression. Decreases in Rap1Gap expression led to changes in adherens junctions via reduction in E-cadherin levels, to cytoskeletal remodeling, and to increases in ERK activation that are correlated with an invasive phenotype in DCIS

  2. Rap1GAP may play a significant role in gastric cancer progression and act as a valuable prognostic marker for gastric cancer.

  3. results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity

  4. Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC).

  5. Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 in vivo.

  6. kidney biopsies from glomerulosclerosis patients exhibited increased RAP1GAP, resulting in diminished glomerular RAP1 activation

  7. findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells.

  8. Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro.

  9. Downregulation of RAP1GAP in thyroid tumors enhances SRC-dependent signals that regulate cellular architecture and motility.

  10. Over-expression of Rap1GAP attenuated levels of both cadherins and integrins that are known to regulate the cancer cells invasion in renal cel carcinoma.

  11. Rap1GAP is a more effective inhibitor of cell-matrix adhesion compared to cell-cell adhesion.

  12. A polycomb-mediated repression of rap1GAP was demonstrated that involves EZH2, a histone methyltransferase in head and neck cancers. It was also shown that the loss of miR-101 expression correlates with EZH2 upregulation and rap1GAP downregulation.

  13. These studies establish that the direct physical interaction of Rap1 with KRIT1 enables the translocation of microtubule-sequestered KRIT1 to junctions, thereby supporting junctional integrity and cardiovascular development

  14. Human kidney cells evidence increased EP4 and decreased Rap1GAP expression levels in the malignant compared with benign samples.

  15. The expression level of RAP1GAp in myelodysplastic syndrome patients significantly increased as compared with patients with non-malignant blood diseases or AML.

  16. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities

  17. Results suggest that downregulation of Rap1GAP in epithelial tumors where alterations in cell/cell and cell/matrix adhesion are early steps in tumor dissemination supports a role for Rap1GAP depletion in tumor progression.

  18. Epigenetic or genetic loss of Rap1GAP is very common in thyroid cancer, where these events are sufficient to promote cell proliferation and invasion.

  19. ERK activation by cAMP does not require RAP1

  20. Rap1 GTPase has functions in malignancy (review)

Mouse (Murine) RAP1 GTPase Activating Protein (RAP1GAP) interaction partners

  1. increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin

  2. Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization

  3. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities

  4. ERK activation by cAMP does not require RAP1

  5. evidence of differential Krit1 and Rap1A expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1, not restricted to vascular endothelial cells.

  6. Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.

  7. Expression studies show that mr-gef is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ).

  8. down-regulation of Rap1 expression following somatostatin treatment is closely related to the diminished LFA-1 expression

  9. forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling

  10. EGF-induced activation of GTPase Rap1 was sensitized in NIH3T3/EGFR-e3B1 cells.

  11. Rap1 stimulates signal transduction pathways that lead to cell proliferation and cell survival, and may play crucial roles in leukemogenesis by BCR/ABL.

  12. CTLA-4 deficient mice show altered RAP-1-mediated adhesion

  13. A signaling module comprising the cytosolic adapter proteins ADAP and SKAP55 is involved in TCR-mediated inside-out signaling and, the interaction between ADAP and SKAP55 is mandatory for integrin activation.

  14. Rap1 and MEKK2 are critical upstream signaling molecules mediating BDNF stimulation of ERK5 in central nervous system neurons

  15. Ras plays a major role in ERK activation by cAMP, PACAP, and KCl, while Rap1 also mediates activation of a selective membrane-associated pool of ERKs.

  16. functional role of Rap1 in male germ cell differentiation

  17. Results describe a link between ADAP/SKAP-55 and the Rap1/RIAM complex and provide a potential new mechanism for T cell receptor-mediated integrin activation.

  18. NF-kappaB activation could be regulated through Epac1-mediated Rap1 stimulation for LPS-induced inflammatory responses in murine macrophages

  19. These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1, mediated by RA-GEF-2, in adhesion signaling.

  20. CD44 stimulation induces inside-out activation of CR3 through the GTPase Rap1

Zebrafish RAP1 GTPase Activating Protein (RAP1GAP) interaction partners

  1. a proper level of Rap1 is crucial for heart morphogenesis and function.

RAP1 GTPase Activating Protein (RAP1GAP) Protein Profile

Protein Summary

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Gene names and symbols associated with RAP1GAP

  • RAP1 GTPase activating protein (RAP1GAP)
  • Rap1 GTPase-activating protein (Rap1gap)
  • RAP1 GTPase activating protein 1 (RAP1GAP1)
  • RAP1 GTPase activating protein L homeolog (rap1gap.L)
  • Rap1 GTPase-activating protein 1 (Tsp_09520)
  • RAP1 GTPase activating protein (rap1gap)
  • RAP1 GTPase activating protein (Rap1gap)
  • 1300019I11Rik protein
  • 2310004O14Rik protein
  • AI427470 protein
  • DKFZp459A114 protein
  • RAP1 protein
  • rap1ga1 protein
  • RAP1GAP protein
  • rap1gap1 protein
  • rap1gapii protein
  • rapgap protein
  • zgc:175180 protein

Protein level used designations for RAP1GAP

rap1 GTPase-activating protein 1 , Rap1, GTPase-activating protein 1 , GTPase activating protein 1 , GTPase activating protein Rap1-GAP , RAP1, GTPase activating protein 1 , Rap1 GTPase-activating protein 1

5909 Homo sapiens
110351 Mus musculus
313644 Rattus norvegicus
395647 Gallus gallus
494835 Xenopus laevis
532839 Bos taurus
10902864 Trichinella spiralis
100144557 Danio rerio
100172787 Pongo abelii
100725658 Cavia porcellus
100340849 Oryctolagus cuniculus
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