RAP1 GTPase Activating Protein Proteins (RAP1GAP)

RAP1GAP encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Additionally we are shipping RAP1 GTPase Activating Protein Antibodies (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RAP1GAP 5909 P47736
RAP1GAP 110351  
Rat RAP1GAP RAP1GAP 313644  
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Top RAP1 GTPase Activating Protein Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

RAP1GAP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for RAP1 GTPase Activating Protein (RAP1GAP) Interaction Partners

Human RAP1 GTPase Activating Protein (RAP1GAP) interaction partners

  1. results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity

  2. Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC (show CYLD Proteins)).

  3. Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 in vivo.

  4. kidney biopsies from glomerulosclerosis patients exhibited increased RAP1GAP, resulting in diminished glomerular RAP1 activation

  5. findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells.

  6. Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro.

  7. Downregulation of RAP1GAP in thyroid tumors enhances SRC (show SRC Proteins)-dependent signals that regulate cellular architecture and motility.

  8. Over-expression of Rap1GAP attenuated levels of both cadherins and integrins that are known to regulate the cancer cells invasion in renal cel carcinoma.

  9. Rap1GAP is a more effective inhibitor of cell-matrix adhesion compared to cell-cell adhesion.

  10. A polycomb (show CBX2 Proteins)-mediated repression of rap1GAP was demonstrated that involves EZH2 (show EZH2 Proteins), a histone methyltransferase in head and neck cancers. It was also shown that the loss of miR (show MLXIP Proteins)-101 expression correlates with EZH2 (show EZH2 Proteins) upregulation and rap1GAP downregulation.

Mouse (Murine) RAP1 GTPase Activating Protein (RAP1GAP) interaction partners

  1. increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin

  2. Plexins are GTPase (show RACGAP1 Proteins)-activating proteins for Rap (show LRPAP1 Proteins) and are activated by induced dimerization

  3. Ca2 (show CA2 Proteins)+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (show RASA1 Proteins) (GAP) and RapGAP activities

  4. ERK activation by cAMP does not require RAP1

  5. evidence of differential Krit1 (show KRIT1 Proteins) and Rap1A (show RAP1A Proteins) expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1 (show KRIT1 Proteins), not restricted to vascular endothelial cells.

  6. Rap1 (show TERF2IP Proteins) couples cAMP signaling to a distinct pool of p42 (show EPB42 Proteins)/44MAPK regulating excitability, synaptic plasticity, learning, and memory.

  7. Expression studies show that mr-gef (show RAPGEF5 Proteins) is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ).

  8. down-regulation of Rap1 (show TERF2IP Proteins) expression following somatostatin (show SST Proteins) treatment is closely related to the diminished LFA-1 (show ITGAL Proteins) expression

  9. forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling

  10. EGF (show EGF Proteins)-induced activation of GTPase (show RACGAP1 Proteins) Rap1 (show TERF2IP Proteins) was sensitized in NIH3T3/EGFR (show EGFR Proteins)-e3B1 (show ABI1 Proteins) cells.

Zebrafish RAP1 GTPase Activating Protein (RAP1GAP) interaction partners

  1. a proper level of Rap1 is crucial for heart morphogenesis and function.

  2. the direct interaction between Rap1 (show TERF2IP Proteins) and KRIT1 (show KRIT1 Proteins) is required for KRIT1 (show KRIT1 Proteins) function in cardiovascular development

RAP1 GTPase Activating Protein (RAP1GAP) Protein Profile

Protein Summary

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Gene names and symbols associated with RAP1GAP

  • RAP1 GTPase activating protein (RAP1GAP)
  • Rap1 GTPase-activating protein (Rap1gap)
  • RAP1 GTPase activating protein 1 (RAP1GAP1)
  • RAP1 GTPase activating protein L homeolog (rap1gap.L)
  • Rap1 GTPase-activating protein 1 (Tsp_09520)
  • RAP1 GTPase activating protein (rap1gap)
  • si:dkey-166d12.2 (si:dkey-166d12.2)
  • RAP1 GTPase activating protein (Rap1gap)
  • 1300019I11Rik protein
  • 2310004O14Rik protein
  • AI427470 protein
  • DKFZp459A114 protein
  • RAP1 protein
  • rap1ga1 protein
  • RAP1GAP protein
  • rap1gap1 protein
  • rap1gapii protein
  • rapgap protein
  • zgc:175180 protein

Protein level used designations for RAP1GAP

rap1 GTPase-activating protein 1 , Rap1, GTPase-activating protein 1 , GTPase activating protein 1 , GTPase activating protein Rap1-GAP , RAP1, GTPase activating protein 1 , Rap1 GTPase-activating protein 1

5909 Homo sapiens
110351 Mus musculus
313644 Rattus norvegicus
395647 Gallus gallus
494835 Xenopus laevis
532839 Bos taurus
10902864 Trichinella spiralis
100144557 Danio rerio
100172787 Pongo abelii
100538309 Danio rerio
100725658 Cavia porcellus
100340849 Oryctolagus cuniculus
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