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RUSC2 encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Additionally we are shipping and RUN and SH3 Domain Containing 2 Kits (1) and many more products for this protein.
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AP-4 deficiency causes missorting of ATG9A in diverse cell types, including patient-derived cells, as well as dysregulation of autophagy.
Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35.
three patients with inherited homozygous nonsense mutations identified in RUSC2 on whole-exome sequencing. All three patients had central hypotonia, microcephaly, and moderate to severe intellectual disability
conclude that Iporin might function as a link between the targeting of ER derived vesicles, triggered by the rab1 GTPase and a signaling pathway regulated by molecules containing SH3 and/or poly-proline regions
This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene.
RUN and SH3 domain containing 2
, RUN and SH3 domain-containing protein 2
, interacting protein of Rab1