RUSC2 antibody (N-Term)

Catalog No. ABIN6991637

Product Details anti-RUSC2 Antibody

Target: RUSC2 (RUN and SH3 Domain Containing 2 (RUSC2))

Binding Specificity: AA 70-120, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUSC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: At least three isoforms are known to exist, this antibody will detect all three isoforms. This antibody is predicted to not cross-react with RUSC1.

Purification: RUSC2 Antibody is affinity chromatography purified via peptide column.

Immunogen: RUSC2 antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human RUSC2. The immunogen is located within amino acids 70 - 120 of RUSC2.

Isotype: IgG

Application Details

Application Notes: RUSC2 antibody can be used for detection of RUSC2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: RUSC2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: RUSC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RUSC2

Target: RUSC2 (RUN and SH3 Domain Containing 2 (RUSC2))

Alternative Name: RUSC2 (RUSC2 Products)

Synonyms: MGC142511 antibody, DKFZp469H2039 antibody, Iporin antibody, AI840675 antibody, mKIAA0375 antibody, RUN and SH3 domain containing 2 antibody, RUSC2 antibody, rusc2 antibody, Rusc2 antibody

Background: RUSC2 Antibody: RUSC2, also known as Iporin, shares with the related protein RUSC1 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30 % amino acid identity. RUSC2 is a rab1-interacting protein that also interacts with GM130, another rab1-interacting protein. RUSC2 interacts with specific rab1 isoforms with different rab-binding specificity. It has been suggested that RUSC2 may function as a link between the targeting of ER derived vesicles triggered by the rab1 GTPase and a signaling pathway composed of proteins containing SH3 and/or poly-proline regions.

Gene ID: 9853

NCBI Accession: NP_055621

UniProt: Q8N2Y8