Recombination Activating Gene 1 Proteins (RAG1)

The protein encoded by RAG1 is involved in activation of immunoglobulin V-D-J recombination. Additionally we are shipping RAG1 Kits (32) and RAG1 Antibodies (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat RAG1 RAG1 84600  
RAG1 5896 P15918
RAG1 19373 P15919
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Top RAG1 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

RAG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Recombination Activating Gene 1 (RAG1) Interaction Partners

Pig (Porcine) Recombination Activating Gene 1 (RAG1) interaction partners

  1. Results confirm that Rag-1 is necessary for the generation of lymphocytes in pigs, and Rag-1-deficient piglets exhibit a T and B cell deficient severe combined immune deficiency(T-B-SCID (show PRKDC Proteins)) phenotype similar to that of rodents and humans.

  2. Piglets with biallelic mutations in either RAG1 or RAG2 (show RAG2 Proteins) exhibit hypoplasia of immune organs, fail to perform V(D)J rearrangement, and lose mature B and T cells.

Human Recombination Activating Gene 1 (RAG1) interaction partners

  1. Estimated disease incidence of RAG1/2 mutations: A case report and querying the Exome Aggregation Consortium.

  2. the ability of the RAG nuclease (show DCLRE1C Proteins) to minimize the risks of genome disruption by coupling the breakage and repair steps of the V(D)J reaction. This implies that the RAG genes, derived from an ancient transposon, have undergone strong selective pressure to prohibit transposition in favor of promoting controlled DNA end joining in cis (show CISH Proteins) by the ubiquitous DNA damage response and DNA repair machineries.

  3. Leaky SCID (show PRKDC Proteins) can be caused by hypomorphic mutations in RAG1 and RAG2 (show RAG2 Proteins) that result in only partial loss of enzymatic function of the proteins respectively encoded by these genes.

  4. We report two siblings with SCID (show PRKDC Proteins) and an atypical phenotype of osteopetrosis (OP (show CSF1 Proteins)). A biallelic microdeletion encompassing the 5' region of TRAF6 (show TRAF6 Proteins), RAG1 and RAG2 (show RAG2 Proteins) genes was identified. TRAF6 (show TRAF6 Proteins), a tumor necrosis factor (show TNF Proteins) receptor-associated family member, plays an important role in T cell signaling and in RANKL (show TNFSF11 Proteins)-dependent osteoclast differentiation and activation but its role in human OP has not been previously reported

  5. The show that DNA damage caused by RAG1 activity in pre-B cells was able to downmodulate RAG1 expression and activity, confirming the existence of a negative feedback regulatory mechanism.

  6. Our findings suggest that mutations in RAG1, specifically the p.R474C variant, can be associated with relatively mild clinical symptoms or delayed occurrence of T cell and B cell deficiencies but may predispose to progressive multifocal leukoencephalopathy.

  7. This study compares T-cell development of patients with RAG1-dependent immune deficiencies, and elucidates important differences that help to explain the wide range of immunologic phenotypes that result from different mutations within the same gene of various patients.

  8. Agammaglobulinemia associated to nasal polyposis due to a hypomorphic RAG1 mutation

  9. mutation c.256_257delAA in RAG1 gene seems to occur quite frequently in the Polish patients with severe combined immunodeficiency (show PRKDC Proteins) and may result in classical OS as well as in severe combined immunodeficiency (show PRKDC Proteins) without clinical and laboratory features of OS when occurred in homozygous state

  10. study reported 4 patients with RAG1 deficiency: classic severe combined immune deficiency (SCID (show PRKDC Proteins)) was seen in 2 patients, Omenn syndrome was observed in 1 patient and atypical SCID (show PRKDC Proteins) was seen in one patient

Mouse (Murine) Recombination Activating Gene 1 (RAG1) interaction partners

  1. this study determined that the depletion of uterine innate lymphoid cells in Rag1-/- mice resulted in impaired uterine spiral artery remodeling and reduced fetal viability

  2. Describe spontaneous S. xylosus infection in a genetically modified murine model. S. xylosus infection in Rag1-/-Tpl2 (show MAP3K8 Proteins)-/- mice correlated with disseminated bacteria and elevated numbers of circulating monocytes.

  3. This study demonstrated that the lymphocyte-deficient Rag1 animals demonstrated a significantly lower rate of aneurysm formation and rupture.

  4. This work provides important mechanistic insight into how spatiotemporal expression of the Rag genes is tightly controlled during B lymphocyte (show AKAP17A Proteins) development to prevent mistimed dsDNA breaks and their deleterious consequences.

  5. a novel RAG1/2-mediated insertion pathway distinct from DNA transposition and trans-V(D)J recombination that destabilizes the genome and shares features with reported oncogenic DNA insertions.

  6. loss of the BH3-only (show BBC3 Proteins) protein BIM (show BCL2L11 Proteins) accelerated lymphoma development in p53 (show TP53 Proteins)-deficient mice. This process was negated by concomitant loss of RAG1/2-mediated antigen receptor gene rearrangement.

  7. Nonamer binding domain (NBD) of RAG1 plays a central role in the recognition of recombination signal sequence.

  8. Overall, these findings suggest that the V(D)J recombination-activating gene 1, RAG1, may play a role in long-term memory consolidation.

  9. propose that pre-B cells toggle between pre-BCR (show BCR Proteins) signals and a RAG1 DNA double-strand break-dependent checkpoint to maintain genome stability while iteratively assembling Igl chain genes

  10. Study reports that RAG1 associates with chromatin at thousands of active promoters and enhancers in the genome of developing lymphocytes. The mouse and human genomes appear to have responded by reducing the abundance of "cryptic" recombination signals near RAG1 binding sites.

Zebrafish Recombination Activating Gene 1 (RAG1) interaction partners

  1. Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations

  2. first report of any rag1(-/-) mutant vertebrate mounting a protective secondary immune response to a bacterial pathogen

  3. target-selected inactivation of the rag1 gene

  4. Rag1 has a role in developing zebrafish cortex-medullary regionalization

  5. by embryonic day 4, rag1 transcripts are seen in the pancreas

  6. Recombination signal sequences are recognized by rag1 protein.

  7. Rag1 expression is restricted to a subpopulation of zebrafish olfactory neurons projecting to the lateral olfactory bulb; Rag11 catalytic activity is not essential for axon targeting

  8. This report describes the leukocyte populations in a unique model, recombination activation gene 1-/- mutant zebrafish (rag1 mutants).

RAG1 Protein Profile

Protein Summary

The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.

Gene names and symbols associated with RAG1

  • recombination activating 1 (Rag1)
  • recombination activating 1 (RAG1)
  • recombination activating gene 1 (RAG1)
  • recombination activating gene 1 (rag1)
  • recombination activating gene 1 (Rag1)
  • recombination activating 1 (rag1)
  • recombination activating gene 1 S homeolog (rag1.S)
  • rag-1 protein
  • rag1 protein
  • rag1a protein
  • RNF74 protein

Protein level used designations for RAG1

V(D)J recombination-activating protein 1 , recombination activation protein 1 , recombination activating gene 1 , recombination activating protein 1 , recombination-activating gene 1 , recombinase activating protein , V(D)J recombination-activating protein 1-like , RING finger protein 74 , recombinase activating gene 1 , etID309719.25 , recombinase , recombination activating protein

84600 Rattus norvegicus
466489 Pan troglodytes
483420 Canis lupus familiaris
506302 Bos taurus
619389 Monodelphis domestica
697322 Macaca mulatta
100049810 Equus caballus
100077097 Ornithorhynchus anatinus
100145555 Xenopus (Silurana) tropicalis
100395720 Callithrix jacchus
100447109 Pongo abelii
100595879 Nomascus leucogenys
397506 Sus scrofa
5896 Homo sapiens
19373 Mus musculus
423164 Gallus gallus
100328950 Oryctolagus cuniculus
30663 Danio rerio
100136833 Oncorhynchus mykiss
100337558 Xenopus laevis
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