anti-Runt-Related Transcription Factor 1 (RUNX1) Antibodies

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Kits (11) and RUNX1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top anti-RUNX1 Antibodies at antibodies-online.com

Showing 10 out of 319 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB AML-1/Runx1 antibody tested by Western blot. Detection of AML-1/Runx1 by Western blot analysis. Positive detection of AML-1/Runx1 in nuclear extracts derived from Jurkat cells at 1:500 (lane 1) and 1:1,000 (lane 2) dilutions. 100 μL Log in to see 1 to 2 Days
$495.83
Details
Cow Rabbit Un-conjugated IHC, WB Sample Type : Mouse, post-natal day (p) 0 retinal ganglion cells Primary Antibody Dilution : 1:1500 Secondary Antibody : Donkey anti rabbit IgG Alexa 594 Secondary Antibody Dilution : 1:1000 Gene Name : RUNX1  Submitted by : Anonymous WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: PANC1 cell lysate There is BioGPS gene expression data showing that RUNX1 is expressed in PANC1 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Jurkat cell lysate RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells WB Suggested Anti-RUNX1 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: Jurkat cell lysate <br /> RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Jurkat cell lysate RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells WB Suggested Anti-RUNX1 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500 <br /> Positive Control: Jurkat cell lysate <br /> RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-RUNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  SH-SYSY cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  Runx1  Sample Type:  Mouse Skeletal Muscle lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  721_B cell lysate RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:7812500  Positive Control:  Human Small Intestine 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-RUNX1/AML1 Picoband antibody ,  All lanes: Anti RUNX1  at 0.5ug/ml WB: Recombinant Human RUNX1 Protein 0.5ng Predicted bind size: 50KD Observed bind size: 50KD Anti-RUNX1/AML1 Picoband antibody ,  IHC(P): Mouse Intestine Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: RUNX1 Antibody [NBP1-89105] - Staining of human bone marrow shows strong nuclear positivity in bone marrow poietic cells. Immunocytochemistry/Immunofluorescence: RUNX1 Antibody [NBP1-89105] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli & vesicles. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details

RUNX1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-RUNX1 Antibodies

  1. Human Polyclonal RUNX1 Primary Antibody for WB - ABIN2668716 : Zaidi, Dowdy, van Wijnen, Lian, Raza, Stein, Croce, Stein: Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. in Cancer research 2009 (PubMed)
    Show all 19 Pubmed References

  2. Human Monoclonal RUNX1 Primary Antibody for ELISA, WB - ABIN969390 : Marshall, Moore, Ohki, Kitabayashi, Patterson, Ornelles: RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. in Journal of virology 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal RUNX1 Primary Antibody for IF, IHC (p) - ABIN514054 : Hussein, Dralle, Theophile, Kreipe, Bock: Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm. in Annals of hematology 2009 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal RUNX1 Primary Antibody for WB - ABIN537342 : Srivastava, Srivastava: Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. in Leukemia research 2005 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal RUNX1 Primary Antibody for ICC, ELISA - ABIN969389 : Zharlyganova, Harada, Harada, Shinkarev, Zhumadilov, Zhunusova, Tchaizhunusova, Apsalikov, Kemaikin, Zhumadilov, Kawano, Kimura, Hoshi: High frequency of AML1/RUNX1 point mutations in radiation-associated myelodysplastic syndrome around Semipalatinsk nuclear test site. in Journal of radiation research 2008 (PubMed)

  6. Human Monoclonal RUNX1 Primary Antibody for IF, IHC (p) - ABIN514053 : Keita, Bachvarova, Morin, Plante, Gregoire, Renaud, Sebastianelli, Trinh, Bachvarov: The RUNX1 transcription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell proliferation, migration and invasion. in Cell cycle (Georgetown, Tex.) 2013 (PubMed)

  7. Cow (Bovine) Polyclonal RUNX1 Primary Antibody for IHC, WB - ABIN2777187 : Takeshita, Ichikawa, Nitta, Goyama, Asai, Ogawa, Chiba, Kurokawa: AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. in Leukemia 2008 (PubMed)

  8. Human Monoclonal RUNX1 Primary Antibody for ELISA, WB - ABIN966980 : Ichikawa, Goyama, Asai, Kawazu, Nakagawa, Takeshita, Chiba, Ogawa, Kurokawa: AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal RUNX1 Primary Antibody for IF, IHC (p) - ABIN2476393 : Tsou, Ransom, Gerlt, Powers, Kenyon: Selection and characterization of a mutant of the cloned gene for mandelate racemase that confers resistance to an affinity label by greatly enhanced production of enzyme. in Biochemistry 1989 (PubMed)
    Show all 2 Pubmed References

  10. Human Polyclonal RUNX1 Primary Antibody for WB - ABIN2801939 : Miyoshi, Shimizu, Kozu, Maseki, Kaneko, Ohki: t(8,21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 4 Pubmed References

More Antibodies against RUNX1 Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. The promoter regions of Runx1 is targets of STAT4 (show STAT4 Antibodies) and that STAT4 (show STAT4 Antibodies) binding during NK cell activation induces epigenetic modifications of Runx1 gene loci resulting in increased expression.

  2. Results suggest that AML1/ETO (show RUNX1T1 Antibodies) expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  3. Gene expression profiling of HEPs revealed a RUNX1c-induced proinflammatory molecular signature, supporting previous studies demonstrating proinflammatory signaling as a regulator of HSC (show FUT1 Antibodies) emergence.

  4. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 (show NFE2 Antibodies) and either RUNX1, FLI1 (show FLI1 Antibodies) or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

  5. the ability of Runx1 to induce endothelial-to-hematopoietic transition (EHT (show CBFA2T2 Antibodies)) in non-hemogenic endothelial cells depends on the anatomical location of the cell and the developmental age of the conceptus

  6. CDK6 (show CDK6 Antibodies) kinase activity negatively regulates the conversion of fat-storing cells into fat-burning cells by suppressing RUNX1, and may be a therapeutic target for the treatment of obesity and related metabolic diseases

  7. RUNX1 dosage plays a pivotal role in hemogenic endothelium maturation and the establishment of the hematopoietic system.

  8. These results suggest that RUNX1 may be an essential modulator in BMP9 (show GDF2 Antibodies)- induced osteogenic differentiation of mesenchymal stem cells.

  9. Loss of Runx1 and Runx2 (show RUNX2 Antibodies) inhibits prostate cell motility.

  10. In vivo, in vitro and systems biology results show that Runx1 exerts a pro-neurogenic function in neural precursor cells in vitro, while in vivo data remained inconclusive.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. specific type of RUNX1 mutation did not affect its association pattern with trisomy 21

  2. High RUNX1 expression is associated with prostatic cancer.

  3. RUNX1 Mutation is associated with acute myeloid leukemia (show BCL11A Antibodies).

  4. The specific association of ZBTB7A (show ZBTB7A Antibodies) mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A (show ZBTB7A Antibodies) and the RUNX1/RUNX1T1 (show RUNX1T1 Antibodies) fusion protein has been reported.

  5. miR (show MLXIP Antibodies)-216a-3p can promote gastric cancer cell proliferation, migration, and invasion via targeting RUNX1 and activating the NF-kappaB (show NFKB1 Antibodies) signaling pathway

  6. the t(5;21)(p15 (show CDKN2B Antibodies);q22) translocation could be identified only when what had seemed like a del(21)(qq) in G-banded preparations was examined using FISH and RNA-sequencing directed at finding out what lay behind the 21q-.

  7. Our findings show the profound impact of RUNX1 allele dosage on gene expression profile and glucocorticoid sensitivity in AML, thereby opening opportunities for preclinical testing which may lead to drug repurposing and improved disease characterization.

  8. This study established inducible RUNX1b/c-overexpressing human embryonic stem cell (hESC) lines, in which RUNX1b/c overexpression prevented the emergence of CD34 (show CD34 Antibodies)+ cells from early stage, thereby drastically reducing the production of hematopoietic stem/progenitor cells. Simultaneously, the expression of hematopoiesis-related factors was downregulated.

  9. Genome-engineered hPSCs expressing ETV6 (show ETV6 Antibodies)-RUNX1 from the endogenous ETV6 (show ETV6 Antibodies) locus show expansion of the CD19 (show CD19 Antibodies)(-)IL-7R(+) compartment

  10. our study demonstrated that specific bone marrow abnormalities and acquired genetic alterations may be harbingers of progression to hematological malignancies in patients with familial platelet disorder with germline RUNX1 mutation.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF Antibodies) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 Antibodies) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (show RAD21 Antibodies), or cohesin subunit Smc3 (show SMC3 Antibodies), fail to express runx3 (show RUNX3 Antibodies) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 Antibodies) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Antigen Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • uncharacterized LOC473981 (LOC473981) antibody
  • runt-related transcription factor (runt) antibody
  • runt related transcription factor 1 (Runx1) antibody
  • runt related transcription factor 1 (RUNX1) antibody
  • runt-related transcription factor 1 (runx1) antibody
  • runt related transcription factor 1 L homeolog (runx1.L) antibody
  • runt-related transcription factor 1 (RUNX1) antibody
  • runt-related transcription factor 1 (Runx1) antibody
  • AI462102 antibody
  • aml antibody
  • aml-1 antibody
  • Aml1 antibody
  • aml1-evi-1 antibody
  • amlcr1 antibody
  • cbfa2 antibody
  • evi-1 antibody
  • Pebp2a2 antibody
  • pebp2ab antibody
  • Pebpa2b antibody
  • Runx-1 antibody
  • runx1 antibody
  • runxa antibody
  • XAML antibody
  • Xaml1 antibody

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
Selected quality suppliers for anti-RUNX1 (RUNX1) Antibodies
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