SH2 Domain Containing 3C Proteins (SH2D3C)

SH2D3C encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. Additionally we are shipping SH2 Domain Containing 3C Antibodies (37) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SH2D3C 10044 Q8N5H7
SH2D3C 27387 Q9QZS8
Rat SH2D3C SH2D3C 362111  
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Top SH2 Domain Containing 3C Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

SH2D3C Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for SH2 Domain Containing 3C (SH2D3C) Interaction Partners

Human SH2 Domain Containing 3C (SH2D3C) interaction partners

  1. The structure of the NSP3-p130Cas (show BCAR1 Proteins) complex reveals that this closed conformation is instrumental for interaction of NSP (show RTN1 Proteins) proteins with a focal adhesion-targeting domain present in Cas (show CSE1L Proteins) proteins.

  2. This protein positively regulates T cell receptor-mediated interleukin-2 (show IL2 Proteins) production by Jurkat cells.

  3. SH2D3C (SHEP1) is less highly expressed than BCAR3 (show BCAR3 Proteins) and NSP1 (show SH2D3A Proteins) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression.

  4. NSP3 overexpression did not induce anti-estrogen resistance in breast tumor cell lines.

Mouse (Murine) SH2 Domain Containing 3C (SH2D3C) interaction partners

  1. Shep1 plays a critical role in the in vivo regulation of Src (show SRC Proteins) activity and Cas (show CTNND1 Proteins) downstream signaling through Crk protein (show CRKL Proteins).

  2. SHEP1 and CasL (show NEDD9 Proteins) are constitutively associated in B cells.

  3. Shep1 plays an important role in the early ingrowth of peripheral olfactory sensory axons into the forebrain.

  4. Sh2d3c is required for proper localization of cells, particularly marginal zone B cells in vivo; thymi of Sh2d3c-deficient mice show no maturational abnormalities.

  5. glutamic acid mutation of tyrosine 635 makes SHEP1 unable to promote Cas (show CTNND1 Proteins)-Crk (show CRK Proteins) association, membrane ruffling, and cell migration toward epidermal growth factor (EGF (show EGF Proteins)), implying that these activities of SHEP1 depend upon a physical interaction with Cas (show CTNND1 Proteins)

SH2 Domain Containing 3C (SH2D3C) Protein Profile

Protein Summary

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SH2D3C

  • SH2 domain containing 3Cb (sh2d3cb)
  • SH2 domain containing 3C (SH2D3C)
  • SH2 domain-containing protein 3C (LOC100466471)
  • SH2 domain containing 3C (sh2d3c)
  • SH2 domain containing 3C L homeolog (sh2d3c.L)
  • SH2 domain containing 3C (Sh2d3c)
  • Chat protein
  • Nsp3 protein
  • PRO34088 protein
  • SH2D3C protein
  • Shep1 protein
  • zgc:56490 protein

Protein level used designations for SH2D3C

SH2 domain containing 3C , SH2 domain-containing protein 3C-like , SH2 domain-containing Eph receptor-binding protein 1 , SH2 domain-containing protein 3C , novel SH2-containing protein 3 , Cas/HEF1-associated signal transducer

GENE ID SPECIES
394051 Danio rerio
464753 Pan troglodytes
699706 Macaca mulatta
100011772 Monodelphis domestica
100070448 Equus caballus
100437299 Pongo abelii
100466471 Ailuropoda melanoleuca
100488781 Xenopus (Silurana) tropicalis
100583826 Nomascus leucogenys
10044 Homo sapiens
379988 Xenopus laevis
491326 Canis lupus familiaris
515820 Bos taurus
27387 Mus musculus
362111 Rattus norvegicus
417225 Gallus gallus
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